CAS: 12230-71-6; Barium Hydroxide Octahydrate

专利信息

专利号:WO-9805658-A1
优先权日:1996-08-07
标 题 :Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1h-imidazole and analogs thereof
发明人：RHO TAIKYUN; LANKIN MICHAEL E; SHIH DAVID H; LANKIN CLAIRE M
权利人:ALTEON INC
摘要:The present invention relates to a practical and facile synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) and analogs thereof. The synthesis utilizes a novel hydrazinium salt as an intermediate reaction product which facilitates the isolation of purified product in high yields.

专利号:US-5856511-A
优先权日:1996-08-07
标题 :Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and analogs thereof
发明人：RHO TAIKYUN; LANKIN MICHAEL E; SHIH DAVID H; LANKIN CLAIRE M
权利人:ALTEON INC
摘要:The present invention relates to a practical and facile synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) and analogs thereof. The synthesis utilized a novel hydrazinium salt as an intermediate reaction product which facilitates the isolation of purified product in high yields.

专利号:US-6303764-B1
优先权日:1998-09-24
标题:Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
发明人：SRIVASTAVA OM; SRIVASTAVA GEETA; DU MINGHUI; HINDSGAUL OLE; BUNDLE DAVID R; LIAV AVRAHAM
权利人:ZYMETX INC; HALIFEX FUND L P
摘要:The present invention provides an improved method of preparing a 4,7-di-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in detecting influenza virus types A and B. The ketosides are substrates that are selectively cleaved by a neuraminidase on influenza virus, but not be neuraminidases found on other viruses or on bacteria. The synthesis is efficient and provides large quantities of the ketoside for commercial development. The synthesis includes a step of alkylating the 4- and 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by a process that comprises contacting the derivative with a composition comprising an alkyl halide to form a 4,7-di-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac. The synthesis alternatively includes protecting the 8- and 9-hydroxyl groups of an alkyl ester alkyl ketoside derivative of Neu5Ac by forming an 8,9-epoxide protected alkyl ester alkyl ketoside derivative of Neu5Ac.

专利号:US-4228295-A
优先权日:1977-02-23
标题 :Novel cycloheptathiophene intermediates for the synthesis of biotin
发明人：CONFALONE PASQUALE N; LOLLAR ELIZABETH D; PIZZOLATO GIACOMO; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.

专利号:US-4124595-A
优先权日:1977-02-23
标题 :Synthesis of biotin
发明人：CONFALONE PASQUALE N; LOLLAR ELIZABETH D; PIZZOLATO GIACOMO; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.

专利号:US-4189586-A
优先权日:1977-08-05
标 题 :Preparation of biotin
发明人：BAGGIOLINI ENRICO G; LEE HSI L; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:A novel procedure for the preparation of biotin employing cysteine as the starting material is disclosed. This synthesis involves the formation of the thiophane ring by a 1,3-dipolar addition. By virtue of this process pure d-biotin can be obtained, thus obviating the need for chemical resolution. Novel intermediates are also disclosed.