CAS: 879-08-3; 2-Amino-9-Ethyl-1H-Purin-6(9H)-One

该化合物是一个经过修改的核库,它是谷氨的衍生物,其特点是在纯环的氮位置9处存在乙基组,这种改变会影响其生物特性和相互作用,特别是在DNA和RNA方面.9-乙基瓜尼的分子式为C7H10N4O,具有反映其结构的分子重量.这一化合物对生物化学研究,尤其是与诱变和DNA修复机制有关的研究感兴趣,因为它有可能改变基配和突变.此外,9-乙基瓜尼可用于研制用于治疗用途的核库模拟物,包括抗病毒剂和抗癌剂.其溶剂的溶性与稳定性各异,这在实验室环境中的应用非常重要.

结构式图片

上下游产品

CAS号130584-29-1 2-amino-6-chlor... | CAS号17495-12-4 2-amino-7-benzy... | CAS号527-57-1 2,5-二氨基-(6ci,7c... | CAS号542-85-8 异硫氰酸乙酯 | CAS号67790-32-3 5-amino-1-ethyl... | CAS号131490-64-7 5-[[N'-benzoyl(... | CAS号137063-90-2 9-Ethyl-O6-meth... | CAS号20535-83-5 2-氨基-6-甲氧基嘌呤 | CAS号10310-21-1 2-氨基-6-氯嘌呤 | CAS号73-40-5 鸟嘌呤 | CAS号87932-57-8 2-amino-9-ethyl... | CAS号89647-28-9 3-ethyl-6-(hydr... | CAS号89647-29-0 3-ethyl-6-methy...

合成工艺路线路线简述

    📜9-Ethyl-O6-Methylguanine置于氢氧化钾体系中,化学反应 1.0H,反应生成 9-乙基鸟嘌呤
    参考文献:N 2 3-乙炔鸟苷和ia'-甲吗啡:5 N NMR光谱和动力学和平衡测量的理化性质的阐明
    标题:N 2 3-乙炔鸟苷和ia'-甲吗啡:5 N NMR光谱和动力学和平衡测量的理化性质的阐明
    摘要:互变异构现象,Ia'-Metamorphosine(的碱基部分的质子和电子特性1A),N 2,3-Ethenoguanosine(2A)和o 6-苄基-N 2,3-Ethenoguanosine(3A中通过研究15 ñNMR光谱.的pk一个相同的化合物的值分光光度法测定,和n-糖苷键的水解稳定性在不同的水合氢离子浓度进行了研究.该碱基堆积能力以及n金属离子络合2,3-Ethenoguanosine和其9-乙基对方(通过相分布和电位测量来阐明7).
    DOI:10.1016/s0040-4020(01)82321-8

    海关参考信息

    专利信息


    专利号:US-2004054162-A1
    优先权日:2001-10-30
    标 题:Molecular detection systems utilizing reiterative oligonucleotide synthesis
    发明人:HANNA MICHELLE M
    摘要:The present invention provides methods for detecting the presence of a target molecule by the use of nucleotide analogs containing moieties that enable detection. Such analogs may be incorporated into nucleic acids. In one embodiment, nucleotide analogs are used in a process generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators or chain terminators to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase.

    专利号:US-2023314322-A1
    优先权日:2022-03-29
    标题:Systems and methods of sequencing polynucleotides
    发明人:CALLINGHAM MICHAEL JAMES; BUREK MICHAEL JOHN; WINNARD CHRISTOPHER; MILLER OLIVER JON
    权利人:ILLUMINA INC; ILLUMINA CAMBRIDGE LTD
    摘要:The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide include attaching three different fluorescent dyes to three different nucleotides during incorporation. In particular, long Stokes shifted dyes may be used to determine the sequence of polynucleotides in a sequencing by synthesis system.

    专利号:WO-2018157153-A1
    优先权日:2017-02-27
    标 题:Large scale synthesis of messenger rna

    专利号:WO-2013038134-A1
    优先权日:2011-09-16
    标题 :Synthesis and anticancer activity of ruthenium (11) cis-cis-1,3,5- triaminocyclohexane complexes
    发明人:GAMBLE AIMEE JOANNA; LYNAM JASON MARTIN; WALTON PAUL HOWARD
    权利人:UNIV YORK; GAMBLE AIMEE JOANNA; LYNAM JASON MARTIN; WALTON PAUL HOWARD
    摘要:There is described a complex of formula I: in which, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each, hydrogen, alkyl CI to 20 alkenyl CI to 20, aryl, alkyl(ci t0 20)aryl, alkenyl(Ci t0 20>aryl, heteroaryl, etc.; R 7 , R 8 and R 9 are each, hydrogen or alkyl CI to 20; L 1 , L 2 and L 3 , are each a ligand; in free or in salt form.

    专利号:WO-2018219107-A1
    优先权日:2017-05-27
    标题:Engineered polypeptides and their applications in synthesis of beta-hydroxy-alpha-amino acids

    专利号:RU-2042668-C1
    优先权日:1989-03-20
    标 题:Method of synthesis of 9-substituted guanine derivatives and 1-substituted 5-(thiocarbamoyl) -amino-1h- imidazole-4- carboxamides

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Alexey A Nazarov, Et Al. Protein Ruthenation And Dna Alkylation: Chlorambucil-Functionalized Rapta Complexes And Their Anticancer Activity. Dalton Trans. 2015 Feb 28;44(8):3614-23.
    [参考文献]: Anne-Mari Ruohola, Et Al. Reactions Of 9-Substituted Guanines With Bromomalondialdehyde In Aqueous Solution Predominantly Yield Glyoxal-Derived Adducts. Org Biomol Chem. 2004 Jul 7;2(13):1943-50.
    [参考文献]: Flavia Barragán, Et Al. Photocontrolled Dna Binding Of A Receptor-Targeted Organometallic Ruthenium(Ii) Complex. J Am Chem Soc. 2011 Sep 7;133(35):14098-108.
    [参考文献]: Helen T Chifotides, Et Al. Novel Binding Interactions Of The Dna Fragment D(Pgpg) Cross-Linked By The Antitumor Active Compound Tetrakis(Mu-Carboxylato)Dirhodium(Ii,Ii). J Am Chem Soc. 2003 Sep 3;125(35):10714-24.
    [参考文献]: Helen T Chifotides, Et Al. Unprecedented Head-To-Head Conformers Of D(Gpg) Bound To The Antitumor Active Compound Tetrakis (Mu-Carboxylato)Dirhodium(Ii,Ii). J Am Chem Soc. 2003 Sep 3;125(35):10703-13.

    合成参考文献


    参考文献:10.1021/ja0168559
    摘要:Komeda S, Lutz M, Spek AL, Yamanaka Y, Sato T, Chikuma M, Reedijk J. A novel isomerization on interaction of antitumor-active azole-bridged dinuclear platinum(II) complexes with 9-ethylguanine. Platinum(II) atom migration from N2 to N3 on 1,2,3-triazole. J Am Chem Soc. 2002 May 01;124(17):4738–46. doi: 10.1021/ja0168559.
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