CAS: 6928-85-4; 4-Methylpiperazin-1-Amine

相似化合物

118753-66-5 40675-60-3 1198285-47-0

上下游产品

CAS号16339-07-4 1-甲基-4-亚硝基哌嗪 | CAS号55-86-7 盐酸氮芥 | CAS号105-59-9 N-甲基二乙醇胺 | CAS号21223-19-8 ch3n(ch2ch2)2nn... | CAS号7732-18-5 水 | CAS号13292-46-1 利福平 | CAS号89316-36-9 N-(4-methylpipe... | CAS号90228-12-9 1-Piperazinecar... | CAS号69241-38-9 N-[2-(2-chlorop...

1-甲基-4-亚硝基哌嗪置于溶剂黄146,锌体系中,用 水 作为反应溶剂,化学反应 5.0H,反应生成 1-氨基-4-甲基哌嗪
参考文献:含有部分的新型联芳恶唑烷酮类似物的合成及其抗菌活性评估
标题:含有部分的新型联芳恶唑烷酮类似物的合成及其抗菌活性评估
摘要:设计,合成和评估了一系列含有a部分的利奈唑胺类似物的抗菌活性.与利奈唑胺和雷地唑利德相比,大多数化合物对金黄色葡萄球菌,Mrsa,Mssa,Lref和vre病原体表现出更强的抗菌活性.与利奈唑胺相比,化合物9A,9C,9F,9G,10M和10T对mrsa,Mssa,Vre和lref的临床分离株更有效.化合物9A对人mao-A表现出与利奈唑胺相当的活性以进行安全性评估,并在人肝微粒体中显示出适度的新陈代谢.最有前途的化合物9A显示针对显着的抗菌活性的金黄色葡萄球菌,Mrsa,Mssa,Lref和vre病原体的0.0675毫克/毫升,分别,为15至30倍利奈唑胺更有效mic值.
DOI:10.1016/j.Ejmech.2018.09.004

专利信息

专利号:US-7879999-B2
优先权日:2003-12-17
标 题:Method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines
发明人：DELALU HENRI; COLAS-DURICHE CECILE; BERTHET JACQUES; LEURENT PHILIPPE
权利人:ISOCHEM SA; CENTRE NAT RECH SCIENT; UNIV CLAUDE BERNARD LYON
摘要:The invention relates to a method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines The invention is characterised in that the method comprises a step consisting in demixing a solution containing said synthesised derivative, by reacting a heterocyclic amine with monochloramine, in an organic phase and an aqueous phase with the addition of anhydrous sodium hydroxide. According to the invention, the starting amine which has not reacted is collected and reused directly without any additional treatment. The inventive method can also be used to obtain the corresponding exocyclic heterocycloalkyl-hydrazine or cycloalkyl-hydrazinederivative derivative at a low cost compared to that of other known methods.

专利号:US-6413957-B1
优先权日:1998-04-21
标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SUIBB PHARMA COM
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:WO-2024134480-A1
优先权日:2022-12-21
标题:Heterocyclic acrylic acid derivatives as monomers for the synthesis of polymers for use in ion exchange articles
发明人：RASMUSSEN JERALD K; HOCHSTEIN REBECCA A; FISHMAN JOSHUA M; VOLOSHIN ALEXEI M; WATTS ANNABELLE; RICHARDSON KRISTOPHER E; BISHOP LOGAN D C; GRIESGRABER GEORGE W; WLASCHIN KATIE F; COLAK ATAN SEMRA; JULIK EMILY; VAIL ANDREW W
权利人:3M INNOVATIVE PROPERTIES COMPANY
摘要:The present invention relates to monomers of formula (I) having a nitrogen atom that can be protonated at relatively low pH values (e.g., less than pH 9.5 or less than pH 9), polymers containing monomeric units derived from these monomers, anion exchange separation articles having the polymers grafted to a porous substrate, and methods of using the anion separation articles to separate mixtures of materials with different ionic content are described. Advantageously, the anion exchange separation articles can be used to separate biomaterials that cannot be subjected to high pH conditions (e.g., greater than 9 or 9.5) and/or to high ionic strength conditions (e.g., greater than 0.5M or 1M).

专利号:US-7935704-B2
优先权日:2003-08-01
标 题 :Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
发明人：PALLADINO MICHAEL A; LLOYD GEORGE KENNETH; HAYASHI YOSHIO; NICHOLSON BENJAMIN
权利人:NEREUS PHARMACEUTICALS INC
摘要:Compounds represented by the following structure (I) are disclosed: n nas are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R 1 , R 1 ′, R 1 ″, R 2 , R 3 , R 4 , R 5 , and R 6 , X 1 and X 2 , Y, Z, Z 1 , Z 2 , Z 3 , and Z 4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

专利号:US-7956058-B2
优先权日:2002-08-02
标 题:Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
发明人：HAYASHI YOSHIO; PALLADINO JR MICHAEL A; GRODBERG JENNIFER
权利人:NEREUS PHARMACEUTICALS INC
摘要:Compounds represented by the following structure (I) are disclosed: n nas are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R 1 , R 1 ′, R 1 ′, R 2 , R 3 , R 4 , R 5 , and R 6 , X 1 and X 2 , Y, Z, Z 1 , Z 2 , Z 3 , and Z 4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.