CAS: 6274-22-2; 4-Amino-N-Methylbenzamide

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CAS号2585-23-1 N-甲基-4-硝基苯甲酰胺 | CAS号1719-57-9 氯甲基二甲基氯硅烷 | CAS号2835-68-9 对氨基苯甲酰胺 | CAS号122-04-3 对硝基苯甲酰氯 | CAS号96-31-1 1,3-二甲基脲 | CAS号150-13-0 对氨基苯甲酸

4-硝基苯甲酰氯置于tin(II) Chloride Dihdyrate,三乙胺体系中,用 二氯甲烷,乙酸乙酯 作为反应溶剂,化学反应 4.0H,反应生成 4-氨基-N-甲基苯甲酰胺
参考文献:2,4-二氨基嘧啶衍生物作为具有抗癌和抗血管反应生成活性的有效 Fak 抑制剂的设计,合成和生物学评价
标题:2,4-二氨基嘧啶衍生物作为具有抗癌和抗血管反应生成活性的有效 Fak 抑制剂的设计,合成和生物学评价
摘要:一系列 2,4-二氨基嘧啶 (Dapy) 衍生物被设计,合成并评估为具有抗肿瘤和抗血管反应生成活性的粘着斑激酶 (Fak) 抑制剂.大多数化合物可有效抑制 Fak 的酶活性,11B和12F的 Ic 50 S分别为 2.75 和 1.87 Nm.11B和12F对七种人类癌细胞表现出强烈的抗增殖作用,对两种过表达 Fak 的胰腺癌细胞(panc-1 和 Bxpc-3)的ic 50值分别为 0.98 μm,0.55 μm 和 0.11 μm,0.15 μm.此外,11B和12F以剂量依赖性方式明显抑制panc-1细胞的集落形成,迁移和侵袭.同时,根据流式细胞术检测,这两种化合物均能诱导panc-1细胞凋亡并在g2/m期阻滞细胞周期.蛋白质印迹显示11B和12F有效抑制fak/pi3K/akt信号通路并显着降低细胞周期蛋白d1和bcl-2的表达.此外,化合物11B和12F有效抑制huvecs的抗增殖并
DOI:10.1016/j.Ejmech.2021.113573

专利信息

专利号:EP-1431274-B1
优先权日:2002-12-18
标题 :Synthesis of mono-N-substituted functionalized anilines
发明人：SELVA MAURIZIO; TUNDO PIETRO
权利人:CONSORZIO INTERUNIVERSITARIO N
摘要:The present invention relates to a process for direct and selective synthesis of mono-N-substituted functionalized anilines by using alkylating agents selected from the class of organic carbonates, preferably of the dialkyl, dibenzyl and diallyl types, in the presence of suitable catalysts that are chemically related to the class of aluminosilicates.

专利号:CN-105367441-B
优先权日:2014-08-18
标 题 :Novel compounds used in the synthesis of enzalutamide

专利号:US-2004127747-A1
优先权日:2002-12-18
标题:Synthesis of mono-N-substituted functionalized anilines

专利号:EP-1431274-A1
优先权日:2002-12-18
标 题:Synthesis of mono-N-substituted functionalized anilines

专利号:WO-9314086-A1
优先权日:1992-01-17
标 题 :Substituted 1-isoquinolone derivatives as angiotensin ii antagonists
发明人：FISHER LAWRENCE E; CAROON JOAN M; STABLER STEPHEN R; CLARK ROBIN D
权利人:SYNTEX INC
摘要:1-Isoquinolone derivatives and related compounds according to formula (I) wherein, Y is selected from the group consisting of H, OH, lower alkoxy, and halo; X is selected from the group consisting of H, lower alkyl acid, lower alkyl ester, and lower alkyl; and R1 is selected from the group consisting of H, alkenyl, lower alkyl, lower cycloalkyl, unsubstituted or substituted 3-spiro-1H-indane of structure (II) wherein R2 is H, OH, lower alkyl, lower alkoxy or halo, and 3-spiro-cycloalkyl of structure (III) wherein n is an integer from zero to six, provided that when R1 is spiro- X is H, or a pharmaceutically acceptable salt thereof, with the proviso that when R1 is spiro-, X is H, and when R1 is H, alkenyl, lower alkyl or lower cycloalkyl substituted at the 3-position of the isoquinolone moiety and X is H or lower alkyl, the (2'-1H--tetrazol-5-yl)biphenyl-4'-ylmethyl group cannot be at the 2(N) position, are useful as angiotensin II receptor antagonists. Also disclosed are methods of synthesis, intermediates, pharmaceutical formulations and methods of treatment.

专利号:US-2016032047-A1
优先权日:2013-03-14
标题 :Peg-based adhesive phenylic derivatives and methods of synthesis and use