CAS: 59219-65-7; (2R,3R,4S,5S,6R)-2-(((2R,4As,4Br,7S,10As)-7-((R)-1,2-Dihydroxyethyl)-1,1,4A,7-Tetramethyl-1,2,3,4,4A,4B,5,6,7,9,10,10A-Dodecahydrophenanthren-2-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
- 英文名称(2R,3R,4S,5S,6R)-2-(((2R,4As,4Br,7S,10As)-7-((R)-1,2-Dihydroxyethyl)-1,1,4A,7-Tetramethyl-1,2,3,4,4A,4B,5,6,7,9,10,10A-Dodecahydrophenanthren-2-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
- 中文名称吡喃葡糖苷
- IUPAC名称(2R,3R,4S,5S,6R)-2-(((2R,4aS,4bR,7S,10aS)-7-((R)-1,2-dihydroxyethyl)-1,1,4a,7-tetramethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthren-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- CAS编号59219-65-7
- MFCD编号:MFCD17214820
- FDA UNII编号:EG8ODI0780
- 分子式:C26H44O8分子量:484.63
- 产品CID: 1568720
- 产品分类天然产物 → 萜类
物理性质
- 熔点234 °C
- 沸点667.0±55.0 °C(预测)
- 闪点359.7 °C
- 密度1.29±0.1 g/cm3(预测)
- pKa:12.91±0.70(预测)
- PSA:139.84
- LogP:1.780 (est)
- 折射率1.587
- 蒸汽压6.98E-21 mmHg at 25 °C
- 溶解性Soluble in methanol and DMSO
- 外观形态白色粉末
- 储存条件2-8°C(避光保存)
- 产品应用该化合物是一种天然甘油化合物,存在于SIELINGIA OIENTALIS和CENTELLA ASIATICATICA等植物中,以其防炎和皮肤再生特性著称. 它广泛用于化妆品和皮肤制品,以提高皮肤弹性,减少伸缩痕迹外观,促进伤口愈合. 达卢托塞特通过刺激聚氨酯和弹性合成,加强皮肤修补和结构完整性.
合成工艺路线路线简述
专利信息
专利号:US-7544375-B1
优先权日:2006-06-12
标 题:Composition
发明人：BELLIN HOWARD T; DE BORG BEATRICE
权利人:SWISS SKIN REPAIR INC
摘要:A topically applied composition or cream for treatment of the skin. A preferred composition includes a) a skin plumper; b) a tetrapeptide; c) a soya plant extract; d) Centella Asiatica extract; e) a cosmetic soothing or anti-inflammatory component; f) a component that acts on fibronectin synthesis; g) a moisturizing component; h) a structured conditioning component; i) an emulsifier component; and j) a transdermal delivery agent.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Gao L, Su J, Guo L, Lin S, Xu J, Liu Y. Darutoside promotes skin wound healing via regulating macrophage polarization. Mol Immunol. 2025 May;181:129-138. doi: 10.1016/j.molimm.2025.03.008. Epub 2025 Mar 25.
268:113547. doi: 10.1016/j.jep.2020.113547. Epub 2020 Nov 3.
9:942303. doi: 10.3389/fmolb.2022.942303.
合成参考文献
参考文献:10.1002/chin.200533233
摘要:Giang PM, Son PT, Otsuka H. ent‐Pimarane‐Type Diterpenoids from Siegesbeckia orientalis L. ChemInform. 2005 Jul 19;36(33). doi: 10.1002/chin.200533233.
参考文献:10.1002/bmc.1481
摘要:Song XL, Zhang QY, Wang ZM, Fu HZ, Qian RQ. A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study. Biomed Chromatogr. 2011 May;25(5):542–6. doi: 10.1002/bmc.1481.
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