CAS: 589-17-3; 1-Bromo-4-(Chloromethyl)Benzene

上下游产品

formaldehyd bromobenzene bis(2-chloromethyl)ether (E)-3-Ureido-but-2-enoic acid ethyl ester 1-(4-bromo-benzyl)-hexahydro-azepine 5-(4-bromo-benzyloxy)-benzo[1,3]dioxole o-tolyl ether(4-bromo-benzyl)-o-tolyl ether 2-(4-bromo-benzyl)-6-methyl-phenol

📜对溴甲苯置于n-氯代丁二酰亚胺,N-羟基邻苯二甲酰亚胺,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 乙腈 作为反应溶剂,化学反应 16.0H,以38%的收率获得产物4-溴苄氯
参考文献:N-羟基琥珀酰亚胺使用n-羟基邻苯二甲酰亚胺/苯醌催化的ch-C烃键氯化反应
标题:N-羟基琥珀酰亚胺使用n-羟基邻苯二甲酰亚胺/苯醌催化的ch-C烃键氯化反应
摘要:近年来,Ch键的直接氯化反应受到了广泛的关注.在这项工作中,对烃的c-H键氯化不含金属的协议与市售ñ氯琥珀酰亚胺(ncs)通过催化ñ提出了具有2,3-二氰基5,6-二氯苯醌(ddq)作为外部自由基引发剂的-羟基邻苯二甲酰亚胺(nhpi).发现脂族和苄基取代基以及杂芳族取代基具有非常好的耐受性.实验和理论分析均表明该反应经历了其中nhpi充当催化剂而不是引发剂的过程.另一方面,由pino物种而不是高反应性n中心自由基进行的c-h键的氢提取使该方案获得的一氯化的高化学选择性合理化,因为后者对c具有反应性(sp 3)-一氯化物的h键.目前的结果有望为进一步开发用于脂肪族和苄基烃ch的高度选择性官能化的硝氧基自由基体系提供希望.
DOI:10.1039/c9Ob00216B

专利信息

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:EP-1326851-B1
优先权日:2000-10-13
标 题 :Substituted dipeptides as growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人：TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

专利号:TW-I867217-B
优先权日:2020-05-06
标题:Synthesis of vinyl cyclobutyl intermediates

专利号:US-7781470-B2
优先权日:1999-09-13
标题:Aminodicarboxylic acid derivatives having pharmaceutical properties
发明人：ALONSO-ALIJA CRISTINA; HEIL MARKUS; FLUBACHER DIETMAR; NAAB PAUL; PERNERSTORFER JOSEF; STASCH JOHANNES-PETER; WUNDER FRANK; DEMBOWSKY KLAUS; PERZBORN ELIZABETH; STAHL ELKE
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, n nwherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.

专利号:US-4618686-A
优先权日:1984-09-27
标 题 :Process for dehalogenation of aryl and alpha-araliphatic halides
发明人：BOYER STEPHEN K
权利人:CIBA GEIGY CORP
摘要:Process for the dehalogenation of aryl and alpha-araliphatic halides comprising contacting the aryl halide or alpha-araliphatic halide with hypophosphite salt, in the presence of a catalytic amount of a noble metal catalyst. This process is useful in the field of organic synthesis and for the removal of environmentally hazardous aryl and alpha-araliphatic halides, including polychlorinated biphenyls and dibenzo-p-dioxins.