CAS: 56253-90-8; Phenylalanine-D5

该化合物是一种氨酸L-苯麻拉尼的分化形式,它用一种稳定的氢同位素,即氢原子取代5个氢原子,代之以一种稳定的氢同位素,这种改变增强了其在各种科学应用中的效用,特别是在NMR光谱镜,这种分泌可以改善光谱分辨率并减少背景噪音.L-phenyl-d5-alaine保留了L-苯麻尼的基本特征,包括其作为蛋白质的建筑块的作用及其参与代谢途径.这是一种必不可少的氨酸,这意味着它必须用饮食取来取代,并因其在多帕胺等...

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L-phenylalanine tert-butyl L-d5-phenylalaninate 2-(2,3,4,5,6-pentadeuteriophenyl)acetonitrile 5]phenylethyl amine[2,3,4,5,6-D5]phenylethyl amine

合成工艺路线路线简述

    📜L-苯丙氨酸置于diclazuril,氘代硫酸体系中,化学反应生成 氘代l-苯丙氨酸
    参考文献:1H NMR研究寻常脱硫弧菌宫崎f的铁细胞色素c3中芳香族残基的性质
    标题:1H NMR研究寻常脱硫弧菌宫崎f的铁细胞色素c3中芳香族残基的性质
    摘要:摘要 建立了在基本培养基中培养这种硫酸盐还原菌的过程中特异标记普通脱硫弧菌宫崎f的四血红素蛋白细胞色素c 3 的条件.苯丙氨酸和酪氨酸残基的氘化效率超过 85%.细胞色素 C 3 具有九个组氨酸,三个酪氨酸和两个苯丙胺残基.八个组氨酸咪唑与四个血红素基团连接.使用氘代细胞色素 C 3,鉴定了完全氧化状态下苯丙氨酸和酪氨酸残基的芳香质子信号.然而,一个苯丙氨酸残基的信号缺失,暂时将其归于 Phe20.his67 的芳香质子信号也被指定为 P 2 H 滴定.它的 Pk 1 远高于游离组氨酸残基的 Pk 1.
    DOI:10.1016/0022-2860(91)87146-9

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    专利信息


    专利号:US-11412771-B2
    优先权日:2019-04-12
    标题 :Composition to improve athletic performance by supporting muscle protein synthesis and mental focus
    发明人:WOLFE ROBERT REESE; WOLFE FREDERICK LEE
    权利人:The Amino Company LLC
    摘要:The present invention generally relates to compositions and methods for supporting exercise performance or activities of daily living. The compositions described herein are pharmaceutical or nutritional compositions suitable for enhancing exercise performance. The compositions are based on a specially formulated mixture of essential amino acids (EAAs) with additional components. The compositions target support of muscle protein synthesis and reduction of muscle breakdown during exercise, increasing muscle blood flow during exercise, decreasing the perception of fatigue by supporting optimal availability of neurotransmitter precursors, providing energy for rapids bursts of exertion during exercise, and maintaining adequate electrolyte balance during exercise.

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    合成参考文献


    参考文献:10.1007/s00360-024-01582-0
    摘要:Cienfuegos IA, Ciotti BJ, Billington RA, Sutton PA, Lamarre SG, Fraser KPP. Life in the margins: the effect of immersion/emersion and tidal cycle on the North Atlantic limpet Patella vulgata protein synthesis rates. J Comp Physiol B. 2024 Dec;194(6):779–92. doi: 10.1007/s00360-024-01582-0.
    参考文献:10.1186/s12967-024-05696-5
    摘要:Wu Y, Ma Y, Li Q, Li J, Zhang D, Zhang Y, Li Y, Li X, Xu P, Bai L, Zhou X, Xue M. Multi-omics analysis reveals phenylalanine enhance mitochondrial function and hypoxic endurance via LKB1/AMPK activation. J Transl Med. 2024 Oct 10;22(1):920.
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