Zinc(II) Acetate Dihydrate 以 Neat (No Solvent)作为反应溶剂,获得 Zinc Diacetate 参考文献:Zinc-67 Nmr Study Of Tetrahedral And octahedral Zinc Sites With Symmetrical Oxygen,Nitrogen,And Sulfur Ligands 标题:Zinc-67 Nmr Study Of Tetrahedral And octahedral Zinc Sites With Symmetrical Oxygen,Nitrogen,And Sulfur Ligands 摘要:我们报告了含有氧,氮和硫配体配位的锌离子化合物的67Zn核磁共振(Nmr)研究.从含有自然丰度和富集67Zn同位素的固体化合物的魔角旋转(Mas)光谱中获得了有关67Zn核四极耦合常数(Nqcc)和化学位移的新信息.在水溶液中也观察到了[Zn(硫脲)4]2+的快速配体交换过程.关键词:67Zn Nmr,核四极耦合常数,配体交换. Doi:10.1139/V99-154
专利号:WO-2020253244-A1 优先权日:2019-06-20 标 题 :Process for catalytic synthesis of lactide 发明人:JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; ZHANG QUANXING 权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD 摘要:The present invention provides a process for the catalytic synthesis of lactide, comprising: mixing a lactic acid oligomer with a composite catalyst; and synthesizing lactide under a heating condition, and collecting the product using a vacuum distillation mode. The used composite catalyst is composed of a zinc or tin compound and an alkali metal compound. Compared with the prior art, the advantages of the present invention are that: the used composite catalyst features a high production rate with a small use amount, a low reaction temperature (150-220°C), and a short reaction time (2-5 h), has a single pass yield that may reach 95% or more, reduces energy consumption compared with the prior art, and facilitates industrial implementations.
专利号:US-2024075466-A1 优先权日:2021-04-09 标 题:One-Pot Synthesis of Transition Metal-Promoted Chabazites 发明人:VAN TENDELOO LEEN; SCHUETZE FRANK-WALTER; VERHEYEN ELKE JANE JUNE 权利人:UMICORE AG & CO KG 摘要:The invention provides methods for a one-pot synthesis of molecular sieves of the CHA-type. The method uses molecular and non-molecular sieves as sources of silicon and aluminum. A first OSDA is selected from tetraethylenepentamine (TEPA) and triethy-lenepentamine (TETA). The synthesis mixture comprises a first metal selected from copper, iron and zinc. Optionally, the synthesis mixture may furthermore comprise a second OSDA and/or a second metal selected from manganese, cesium, magnesium, calcium, strontium, barium, yttrium, titanium, zirconium, niobium, iron, zinc, silver, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium and mixtures thereof. The molecular sieves of the CHA-type obtainable by the method can be used as SCR-catalytically active substances for the removal of nitrogen oxides from exhaust gases of combustion engines.
专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-2022297078-A1 优先权日:2019-08-08 标题 :Sonochemical synthesis of particles 发明人:POZZO LILO D; KASTILANI RYAN; BISHOP BRITTANY P; LI DAVID SHICHENG 权利人:UNIV WASHINGTON 摘要:Sonochemical synthesis methods of particles (e.g., nanoparticles, microparticles, quantum dots) in emulsion reaction mixtures are described herein. The methods allow for control of the bulk temperature of the reaction mixtures to minimize the effects of solvent temperature increases. The sonochemical synthesis methods (e.g., in emulsion reaction mixtures) offer efficient, accelerated, and controllable pathways towards the on-demand synthesis of complex materials.
专利号:US-7247752-B2 优先权日:2004-10-01 标 题 :Methods for the synthesis of astaxanthin 发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID 权利人:CARDAX PHARMACEUTICALS INC 摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.
专利号:US-6168931-B1 优先权日:1999-03-17 标题 :Enhanced in vitro synthesis of biological macromolecules using a novel ATP regeneration system 发明人:SWARTZ JAMES R; KIM DONG-MYUNG 权利人:UNIV LELAND STANFORD JUNIOR 摘要:Compositions and methods are provided for the enhanced in vitro synthesis of biological molecules where ATP is required for synthesis. Of particular interest is the synthesis of polymers, e.g. nucleic acids, polypeptides, and complex carbohydrates. A homeostatic system is used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. Since inorganic phosphate can be an inhibitory by-product of synthesis, the period of time when synthesis is maintained in vitro can be extended. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.
参考文献:10.1111/j.1742-4658.2011.08240.x 摘要:Bailey J, Powell L, Sinanan L, Neal J, Li M, Smith T, Bell E. A novel mechanism of V‐type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. The FEBS Journal. 2011 Aug 11;278(17):3140–51. doi: 10.1111/j.1742-4658.2011.08240.x. 参考文献:10.1016/j.ejogrb.2011.06.040 摘要:Masciullo M, Modoni A, Bianchi MLE, De Carolis S, Silvestri G. Positive outcome in a patient with Wilson's disease treated with reduced zinc dosage in pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2011 Nov;159(1):237–8. doi: 10.1016/j.ejogrb.2011.06.040.