CAS: 540-63-6; 1,2-Ethanedithiol

上下游产品

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三硫代碳酸乙烯酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,以86%的收率获得产物1,2-乙二硫醇
参考文献:Jordis,Ulrich; Rudolf,Manfred,Phosphorus And Sulfur And The Related Elements,1984,Vol. 19,P. 279-284
标题:Jordis,Ulrich; Rudolf,Manfred,Phosphorus And Sulfur And The Related Elements,1984,Vol. 19,P. 279-284

专利信息

专利号:US-2003125243-A1
优先权日:2000-07-20
标题:Synthesis of cyclic peptides
发明人：LIU JUN; DAI XUEDONG; SU ZHUANG
摘要:The cyclic pentapeptide cyclo(-Arg-Gly-Asp-D-Phe-Lys-) is a highly potent and selective inhibitor for the α v β 3 integrin. A related compound, cyclo(-Arg-Gly-Asp-D-Phe-Val-), is a promising anticancer drug candidate; it has been found to inhibit angiogenesis and induce apoptosis in vascular cells. We have developed a synthesis of arginine containing cyclic peptides using the cyclizcation reagent 1-propanephosphonic acid cyclic anhydride (T3P) and the guanidine protecting group, 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pbf). This improved synthesis is environmentally friendly and is generally applicable to the synthesis of other cyclic peptides.

专利号:US-8193384-B2
优先权日:2005-07-29
标 题 :Polymer-bound phosphitylating reagents for the synthesis of organophosphorus compounds
发明人：PARANG KEYKAVOUS; AHAMDIBENI YOUSEF
权利人:PARANG KEYKAVOUS; AHAMDIBENI YOUSEF; RHODE ISLAND EDUCATION
摘要:The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, β-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups.

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:WO-9817677-A1
优先权日:1996-10-24
标 题 :Improvements in solid-phase synthesis of peptides and related compounds
发明人：ENGLEBRETSEN DARREN
权利人:UNIV QUEENSLAND; ENGLEBRETSEN DARREN
摘要:The invention relates to spacers for use in solid-phase synthesis of peptides and peptide-related compounds, in which a spacer construct is used to ensure that the target peptide or peptide-related compound is at a distance equivalent to at least 5-15 amino acids from the solid support. Constructs of the invention are particularly applicable to the synthesis of strongly hydrophobic peptide, which are otherwise difficult, if not impossible to purify and analyse. The constructs and methods of the invention are also applicable to synthesis of peptide nucleic acids.

专利号:WO-2018020240-A1
优先权日:2016-07-27
标 题:Process for the synthesis of semiconductor nanocrystals
发明人：HOU BO; CHA SEUNGNAM
权利人:UNIV OXFORD INNOVATION LTD
摘要:The invention relates to a process for the synthesis of semiconductor nanocrystals, comprising mixing a nonaqueous solution of a metal precursor with a solid-state chalcogen and reacting the resulting mixture at a temperature of about 90 °C or greater. In another aspect the invention relates to the use of a solid chalcogen in the heterogeneous synthesis of metal chalcogenide semiconductor nanocrystals. Semiconductor nanocrystals obtainable by the processes of the invention are further provided. In particular, nanocrystalline PbS or PbSe having a band gap of greater than 1.6 eV and/or a photoluminescence emission wavelength of about 440 to about 515 nm, and nanocrystalline ZnS or ZnSe having a photoluminescence emission wavelength of about 410 to about 430 nm, and solar cells comprising such nanocrystals, are provided.

专利号:US-7714063-B2
优先权日:2007-11-15
标 题 :Solid support for Fmoc-solid phase synthesis of peptides
发明人：SRIVASTAVA KRIPA SHANKER; DAVIS MATTHEW RYAN
权利人:MALLINCKRODT INC
摘要:The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.