CAS: 502496-36-8; 3-Bromo-5-Fluoro-2-Methylaniline

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CAS号502496-33-5 2-溴-4-氟-6-硝基甲苯 | CAS号367-29-3 5-氟-2-甲基苯胺 | CAS号446-10-6 4-氟-2-硝基甲苯 | CAS号885698-71-5 6-氟-4-(4,4,5,5-...

5-氟-2-甲基苯胺置于溴体系中,化学反应生成 2-甲基-3-溴-5-氟苯胺
参考文献:Indenylacetic Acid Compounds
标题:Indenylacetic Acid Compounds
摘要:4,5,6或7芳基取代的茚基乙酸及其药用可接受的盐,酰胺和酯.4,5,6或7芳基取代的茚基乙酸具有抗炎,退热和镇痛活性.该发明还包括这些化合物的制备方法,药物组合物和通过向患者施用这些特定化合物治疗炎症的方法.

专利信息

专利号:US-9834551-B2
优先权日:2013-04-18
标 题 :Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANGIREDDY PARAMAREDDY; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention relates to compounds described by Formula I: n nsalts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.