CAS: 43121-43-3; Triadimefon

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(S)-三唑酮 以 水 作为反应溶剂,化学反应生成 三唑酮
参考文献:表征三唑酮消旋动力学和机理的综合实验和计算方法
标题:表征三唑酮消旋动力学和机理的综合实验和计算方法
摘要:手性分子的对映异构体通常表现出不同的药代动力学和毒性,这在评估生物学和环境的命运以及对人类和环境的潜在风险时可能会带来很大的不确定性.然而,人们对外消旋作用(一种对映异构体不可逆转化为外消旋混合物)和对映异构化(一种对映异构体可逆转化为另一种对映异构体)的了解很少.为了更好地了解这些过程,我们研究了在土壤,水和有机溶剂中经历消旋作用的手性杀菌剂三唑酮.核磁共振(NMR)和气相色谱/质谱(gc / Ms)技术用于测量h中三唑酮的对映异构化和外消旋化速率,氘同位素效应和活化能2 O和d 2 O.从这些结果我们能够确定的是:1)三唑酮的α羰基碳是反应部位; 2)裂解c-h(c-d)键是决定速率的步骤; 3)反应是碱催化的;4)反应可能涉及对称中间体.理论水平的b3Lyp / 6-311 + G **用于计算优化的几何结构,谐波振动频率,自然种群分析以及三唑酮在水中的内在反应坐标,并假设了三种消旋
DOI:10.1002/chir.22622

专利信息

专利号:US-2012058520-A1
优先权日:2009-05-14
标 题:Method for synthesis of double-stranded dna corresponding to rna, and method for amplification of the dna
发明人：HAYASHIDA YUKINOBU
权利人:HAYASHIDA YUKINOBU; WAKO PURE CHEM IND LTD
摘要:An object of the present invention is to provide an inexpensive and simple method for synthesis of a double-stranded DNA corresponding to a particular RNA, and a method for amplification of the aforementioned double-stranded DNA. The present invention relates to a method for synthesis of a double-stranded DNA having a nucleotide sequence corresponding to template RNA having polyA, comprising step 1 in which reverse transcription reaction of template RNA is carried out employing oligo(dT)primer to which DNA fragment having a known sequence has been added at the 5′-terminal, to obtain a single-stranded DNA, and step 2 in which double strand formation reaction of single-stranded DNA obtained in step 1 is carried out employing a random primer to which DNA fragment having a known sequence has been added at the 5′-terminal, in the presence of polymerase which does not have 3′→5′ exonuclease activity nor strand displacement activity, to obtain a double-stranded DNA, as well as a method for amplification of a double-stranded DNA having a nucleotide sequence corresponding to template RNA having polyA, further comprising step 3 in which PCR reaction is carried out using the obtained double-stranded DNA.

专利号:US-4751312-A
优先权日:1984-07-20
标 题:Process and intermediates for the synthesis of diastereomeric compounds
发明人：GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF
权利人:BAYER AG
摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).

专利号:US-2014349962-A1
优先权日:2013-05-24
标 题 :Rapid two-step synthesis of anti-coagulants
发明人：ROSENBERG ROBERT D; BALAGURUNATHAN KUBERAB
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides methods for the production of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, compounds thus obtained and compositions comprising same. This invention also provides applications of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, and compositions comprising same, for use in controlling coagulation and treating thrombosis.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-4339612-A
优先权日:1980-03-05
标题:Preparation of 3,3-dimethyl-1-phenoxy-butan-2-ols as fungicide intermediates
发明人：KRANZ ECKART; SIEGLE PETER
权利人:BAYER AG
摘要:3,3-Dimethyl-1-phenoxy-butan-2-ols of the formula ##STR1## in which Y is a halogen atom, an optionally substituted phenyl radical, an optionally substituted phenoxy radical or a nitro, cyano, alkyl, alkoxy, alkoxycarbonyl or cycloalkyl radical, and n is 0, 1, 2 or 3, n exhibit plant growth stimulating properties and are also useful in the synthesis of known fungicides. They are produced from tert-butyloxirane and the corresponding phenols.