CAS: 37943-90-1; Diphenyl-2-Pyridylphosphine

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CAS号109-04-6 2-溴吡啶 | CAS号1079-66-9 氯代二苯基膦 | CAS号109-09-1 2-氯吡啶 | CAS号100-70-9 2-氰基吡啶 | CAS号17154-34-6 二苯基(三甲基硅基)膦 | CAS号829-85-6 二苯基膦 | CAS号603-35-0 三苯基膦 | CAS号15475-27-1 二苯基磷酸钾 | CAS号67-56-1 甲醇 | CAS号1186392-98-2 diphenyl(2-pyri... | CAS号152194-39-3 6-(二苯基膦)-2,2'-联吡啶 | CAS号554-12-1 丙酸甲酯 | CAS号80-62-6 甲基丙烯酸甲酯 | CAS号162753-00-6 2-CHLORO-6-(DIP... | CAS号64741-27-1 2,6-双二苯基膦基吡啶

苄基二苯膦置于15-冠醚-5,Sodium体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.5H,反应生成 二苯基-2-吡啶膦
参考文献:通过钠选择性裂解c-P键从arcl制备有机膦的方法
标题:通过钠选择性裂解c-P键从arcl制备有机膦的方法
摘要:研究了磷化钠r 2 Pna和其他碱金属磷化物r 2 Pm(m = Li和k)的制备,应用和反应机理.r 2 Pna可以通过sd(精细分散在矿物油中的钠)与次膦酸酯r 2 Por'和氯膦r 2 Pc1的反应准确而选择性地制备.r 2 Pna也可以通过选择性裂解c-p键由三芳基膦和二芳基膦制备.在这些反应中,Na优于li和k.r 2 Pna与多种arcl反应以有效产生r 2Par.arcl优于arbr和ari,因为它们只会降低产品收率.另外,Ph 2 Pna优于ph 2 Pli和ph 2 Pk,因为ph 2 Pli不产生与phcl的偶联产物,而ph 2 Pk仅产生低产率的产物.arcl苯环上的吸电子基团极大地促进了与r 2 Pna的反应,而烷基降低了反应活性.氯乙烯和烷基氯rc1也有效地反应.当t-Bucl没有产生相应的产物,金刚烷基卤化物可以高产率得到相应的膦.通过这种方法,由相应的氯化物制备了多种膦.还可以方便地从ph
DOI:10.1021/acs.Organomet.0C00295

专利信息

专利号:EP-0842924-B1
优先权日:1996-11-14
标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
发明人：WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o

专利号:US-5831128-A
优先权日:1996-12-04
标题 :Synthesis of aromatic amines from chloroamatics
发明人：BELLER MATTHIAS; RIERMEIER THOMAS; REISINGER CLAUS PETER; HERRMANN WOLFGANG ANTON; GEISSLER HOLGER
权利人:HOECHST AG
摘要:The present invention relates to a process for the preparation of aromatic amines of the formula (I) n n Ar--NR.sup.1 R.sup.2 (I) n n in which Ar is ##STR1## and R 3 to R 9 independently of one another are hydrogen, C 1 -C 8 -alkyl, alkoxy-(C 1 -C 8 ), acyloxy-(C 1 -C 8 ), OAr, Ar, fluorine, chlorine, bromine, iodine, OH, NO 2 , CN, CO 2 H, CHO, SO 3 H, SO 2 R, SOR, NH 2 , NH-alkyl-(C 1 -C 12 ), N-alkyl 2 -(C 1 -C 12 ), NHCO-alkyl-(C 1 -C 12 ), CO-alkyl-(C 1 -C 12 ), NHCHO, COAr, CO 2 Ar, CF 3 , CONH 2 , CHCHCO 2 R, POAr 2 , PO-alkyl 2 -(C 1 -C 12 ), 5-ring heteroaryl, 6-ring heteroaryl, Si-alkyl 3 -(C 1 -C 12 ), where R=alkyl(C 1 -C 8 ), aryl(C 5 -C 10 ) and R 1 and R 2 independently of one another are hydrogen, C 1 -C 12 -alkyl, Ar as defined above, 5-ring heteroaryl, 6-ring heteroaryl, by reacting chloroaromatics of the formula II n n Ar--Cl (II) n n with ammonia or primary or secondary amines of the formula III n n R.sup.1 R.sup.2 NH (III) n n in which Ar and R 1 and R 2 are as defined above, which comprises reacting the starting materials in the presence of a palladium catalyst, a strong base and a halide cocatalyst in an inert solvent at temperatures of 80°-200° C.

专利号:US-8697902-B2
优先权日:2008-06-17
标 题:Preparation of nitriles from ethylenically unsaturated compounds
发明人：MASTROIANNI SERGIO
权利人:MASTROIANNI SERGIO; RHODIA OPERATIONS
摘要:A process for the hydrocyanation of a hydrocarbon-based compound having at least one site of ethylenic unsaturation into a nitrile compound includes reaction thereof, in a liquid medium, with hydrogen cyanide in the presence of a catalyst containing a metal element selected from among the transition metals and an organophosphorus ligand, wherein the organophosphorus ligand is a compound of formula (I): n n n n n n n n n n The subject process is particularly useful for the synthesis of adiponitrile from butadiene.

专利号:WO-9962854-A1
优先权日:1998-06-01
标 题:Solution phase synthesis of olefins and olefin-derived products
发明人：ORGAN MICHAEL G; DIXON CRAIG E; KALDOR STEPHEN W; SIEGEL MILES G
权利人:LILLY CO ELI; ORGAN MICHAEL G; DIXON CRAIG E; KALDOR STEPHEN W; SIEGEL MILES G
摘要:This invention relates to a process for producing a plurality of olefin compounds of formula (I). The method is ideal for generating libraries of compounds for high throughput screening. The invention also provides a library of above compounds physically separated from one another in a reaction vessel. This library is useful for optimizing the activity of therapeutically useful compounds.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-9233917-B2
优先权日:2008-06-17
标题:Preparation of nitriles from ethylenically unsaturated compounds
发明人：MASTROIANNI SERGIO
权利人:MASTROIANNI SERGIO; INVISTA NORTH AMERICA SARL
摘要:A process for the hydrocyanation of a hydrocarbon-based compound having at least one site of ethylenic unsaturation into a nitrile compound includes reaction thereof, in a liquid medium, with hydrogen cyanide in the presence of a catalyst containing a metal element selected from among the transition metals and an organophosphorus ligand, wherein the organophosphorus ligand is a mixture of at least one monodentate organophosphite compound and at least one monodentate organophosphine compound; the subject process is especially useful for the synthesis of adiponitrile from butadiene.