CAS: 36282-40-3; 3-Methoxyphenylmagnesium Bromide

该化合物是一种有机磁性化合物,具体地说是一种灰色试剂,其特点是在有机合成中具有反应力和效用;其特点是一个苯基组,代之以代形位置的甲氧组,这增强了其核核素性;该化合物的制造通常是用三甲基苯基溴与氢醚溶剂,如二乙醚或四氢呋喃中的镁反应;作为灰色剂,它高度反应于电极,使其在各种合成途径,包括酒精,氯酮和其他功能组的合成过程中形成碳-碳联结,使其具有价值;然而,它对水和空气敏感,需要在惰性条件下进行谨慎处理,以防止分解;该甲基氧组的存在可影响其参与反应的再生性和选择性,往往导致再生选择性结果.总体而言,三甲基氧苯基磺酸溴是合成有机化学领域的重要再生剂.

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CAS号2398-37-0 间溴苯甲醚 | CAS号491-37-2 2,3-二氢苯并吡喃-4-酮 | CAS号7439-95-4 镁标准溶液 | CAS号10540-43-9 1-fluoro-4-(3-m... | CAS号107328-74-5 4-(3-methoxyphe... | CAS号106164-13-0 (3-methylsulfin... | CAS号38087-96-6 2-联苯-(3-甲氧基)羧酸 | CAS号1446-24-8 3-烯丙基苯酚 | CAS号5020-41-7 2-(3-甲氧基苯基)乙醇 | CAS号4373-67-5 3-(3-甲氧基苯基)吡啶 | CAS号17595-93-6 2-(3-Methoxyphe... | CAS号6161-50-8 3,3-二甲氧基联苯 | CAS号492-97-7 2,2'-双噻吩

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    专利信息


    专利号:US-6784319-B2
    优先权日:2001-10-03
    标题 :Synthesis of (±)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
    发明人：KUPPER ROBERT J; STUMPF ANDREAS
    权利人:EURO CELTIQUE SA
    摘要:Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods of preparing (±)-cis-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol, are disclosed herein. In one embodiment, the (±)-2-((dimethylamino)methyl)cyclohexanone and transition-metal salt are in the form of a (±)-2-((dimethylamino)methyl)cyclohexanone:transition-metal salt complex. In another embodimemt, aryl is 3-methoxyphenyl.

    专利号:US-7301049-B2
    优先权日:2001-06-21
    标 题:Photolabile esters and their uses
    发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
    权利人:CANCER RES INST
    摘要:Compounds which are capable of generating acid on photolysis are disclosed, and the uses of these compounds, especially for deprotecting the termini of nucleic acid molecules or peptides during synthesis of arrays. The compounds described herein may be employed in the detritylation of 5′-O-dimethoxytrityl (DMT) protected nucleotides by photolysing the compounds to generate an acid capable of removing the DMT group allowing oligonucleotide arrays to be synthesised using readily available 5′-O-DMT-nucleoside-3′-O-phosphoramidite monomers conventionally used in solid phase nucleic acid synthesis. A method of avoiding the effects of stray light in projection lithography techniques is also disclosed.

    专利号:US-2004054209-A1
    优先权日:2001-10-03
    标题:Synthesis of (±)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols

    专利号:CN-109232386-A
    优先权日:2018-11-12
    标 题:A kind of method for asymmetric synthesis of (S)-propramole

    专利号:WO-03029186-A1
    优先权日:2001-10-03
    标 题 :Synthesis of (±)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols

    专利号:EP-1438284-A1
    优先权日:2001-10-03
    标题:Synthesis of ( )-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols

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    合成参考文献


    摘要:Gagnon, A.; Benoit, E.; Le Roch, A., Science of Synthesis Knowledge Updates, (2018) 4, 2.
    摘要:Lu, J.-M.; Shao, L.-X., Science of Synthesis Knowledge Updates, (2020) 3, 362.
    摘要:Stankevič, M.; Pietrusiewicz, K. M., Science of Synthesis Knowledge Updates, (2013) 2, 329.
    摘要:Bredenkamp, A.; Kirsch, S. F., Science of Synthesis Knowledge Updates, (2014) 4, 431.
    摘要:Wolf, C., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 875.
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