专利号:WO-9517903-A1 优先权日:1993-12-28 标 题:Modular design and synthesis of oxazolone-derived molecules 发明人:HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG 权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG 摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.
专利号:US-5990341-A 优先权日:1993-11-08 标 题 :Diastereoselective synthesis hydroxyethylene dipeptide isosteres 发明人:LIOTTA DENNIS C; LAGU BHARAT RAMKRISHNA 权利人:UNIV EMORY 摘要:A process for the synthesis of hydroxyethylene dipeptide isosteres from α-N,N-di(protected)amino(alkyl or substituted alkyl) methyl ketones that can be efficiently carried out on an industrial scale. The process proceeds with excellent diastereoselectivity and chemical efficiency, and can be used to prepare a wide variety of hydroxyethylene dipeptide isosteres for a variety of uses, including as HIV-1 protease inhibitors and renin inhibitors.
专利号:WO-2005103035-A1 优先权日:2004-04-23 标题:Modified fischer indole synthesis of eletriptan 发明人:ASHCROFT CHRISTOPHER PAUL 权利人:PFIZER LTD; ASHCROFT CHRISTOPHER PAUL; PFIZER 摘要:The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2 is an aldehyde group (-CHO) or the functional equivalent thereof.
专利号:US-2014303333-A1 优先权日:2011-10-14 标题:Iron bisphenolate complexes and methods of use and synthesis thereof 发明人:SHAVER MICHAEL P; KOZAK CHRISTOPHER M 权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC 摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.
专利号:US-9045511-B2 优先权日:2010-06-29 标 题:Supported ligands having a high local density of coordinating atoms 发明人:HIERSO JEAN-CYRILLE; BEAUPERIN MATTHIEU; MEUNIER PHILIPPE 权利人:HIERSO JEAN-CYRILLE; BEAUPERIN MATTHIEU; MEUNIER PHILIPPE; CENTRE NAT RECH SCIENT; UNIV BOURGOGNE 摘要:The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis.
专利号:US-5663449-A 优先权日:1989-05-19 标 题 :Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines
[参考文献]: Kristin M Brinner, Et Al. A Rapid And General Method For The Asymmetric Synthesis Of 2-Substituted Pyrrolidines Using Tert-Butanesulfinamide. Org Biomol Chem. 2005 Jun 7;3(11):2109-13.
合成参考文献
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