CAS: 21145-77-7; 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-Tetrahydronaphthalen-2-yl)Ethanone
该化合物是有机化合物,其结构复杂,包括含有多甲基组和一氯酮功能组的氯化萘衍生物,其特点是无色的黄色液体或固态,取决于其纯度和温度;因其芳香特性而闻名,并经常用于香味配方;四氢和六甲基组的存在有助于其独特的化学行为,影响其溶性与再活性;此外,该化合物可能展示具体的生物活动,使其在包括制药和材料科学在内的各个领域具有兴趣;应参考安全数据,以便处理和接触任何化学物质.
- 英文名称1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-Tetrahydronaphthalen-2-yl)Ethanone
- 中文名称吐纳麝香
- IUPAC名称1-(3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one
- 其它别名1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-Tetrahydro-2-Naphthalenyl)Ethanone; 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-Hexamethyl-2-Naphthalenyl)-Ethanone; 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-Hexamethyl-2-Naphtalenyl)-Ethan-1-One; 6-Acetyl-1,1,2,4,4,7-Hexamethyltetraline; Tonalid; Tonalide; Tonalid(R) Ii; Ahtn
- CAS编号21145-77-7
- MFCD编号:MFCD00437355
- EINECS号:244-240-6
- 分子式:C18H26O
- 分子量:258.41
- 产品CID: 1093458
- 产品分类香精与香料 → 合成香料 → 麝香和大环类香料
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07 & GHS09;
注释: Exclamation mark & Environment - 危险类别急性毒性 类别4(经口)
水生急性毒性 类别1
水生慢性毒性 类别1
水生慢性毒性 类别2 - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
H411 |对水生生物有毒并具有长期持续影响. - 防范说明P301+P312+P330
- UN编号NONH for all modes of transport
- 危险品标志Xn
- 安全声明IDENTIFICATION AND USE: Tonalide is a solid with a musk odor. It is used as a fragrance in cosmetics, detergents, fabric softeners, household cleaning products and air fresheners. HUMAN STUDIES: No irritation was observed after repeated occlusive applications as well as no phototoxic reactions. High concentrations of tonalide can affect steroidogenesis in vitro using the H295R cell line. Tonalide was not genotoxic in the micronucleus test with human lymphocytes in vitro with or without metabolic activation. ANIMAL STUDIES: Tonalide did not produce erythema or edema when tested on the skin of rabbits. In tests for photoirritation in the rabbit clear phototoxicity was seen at 5% in ethanol. Moderate redness and slight to moderate chemosis of the conjunctivae was seen in rabbits in an eye irritation test. A single high dose of tonalide leads to acute hepatic damage in rats. In other experiment, rats were treated with doses 1260, 1588, 2000 or 2520 mg/kg bw and observed for 14 days. The majority of animals showed lethargy, piloerection, hunched position, oscillated movements, shaggy coat and emaciation. Other occasional signs included green urine, hypothermia, half-closed eyes, difficult breathing and increased breathing, prostration and lacrimation. In a 2-week study, groups of 5 male and female rats were administered dietary doses of 0, 33, 88 and 169 mg/kg bw/day for males and 0, 32, 91 and 150 mg/kg bw/day for females. All animals in the high dose group had marked reduction in food consumption and body weight losses. Food consumption and body weight losses were slightly reduced at the mid-dose. In a two generation developmental study in rats, there were no adverse effects to the dams or offspring up to and including the highest dose level (20 mg/kg bw/day). In genotoxicity studies no positive responses were observed except for cells with structural aberrations in the in vitro cytogenetics assay in CHO cells with metabolic activation. ECOTOXICITY STUDIES: In Dreissena polymorpha, tonalide exposure induced lipid peroxidation and increased carbonyl content alone with significant increases in DNA strand breaks, but no fixed genetic damage was observed. Cytochrome P450 isoforms are potentially sensitive targets of synthetic musk substances in fish. There was no observed significant effect on the growth rate of E. fetida after a 28-day tonalide exposure except that at the highest concentration 100 ug/g, whereas a significant decrease of cocoon production was found in earthworms exposed to 50 and 100 ug/g.
- 危险类别码22
- WGK Germany3
欧盟法规
欧盟化妆品法规附录三-限用物质清单REACH注册ECHA物质ECHA物质C&L通报REACH预注册上下游产品
1,1,2,4,4,7-hexamethyl-1,2,3,4-tetrahydro-naphthalene acetyl chloride 2,3-Dimethyl-2-butene 1-methyl-4-isopropenylbenzene合成工艺路线路线简述
2,3-二甲基-2-丁醇置于三氯化铝,硫酸体系中,化学反应生成吐纳麝香
参考文献:Polycyclic Musks. I. Acyl-And Dinitropolyalkyltetralin Derivatives
标题:Polycyclic Musks. I. Acyl-And Dinitropolyalkyltetralin Derivatives
摘要:
Doi:10.1021/jo01044A022
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2912110000-甲醛
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主要参考文献
1: Su C, Liu X, Zhang K, Jiang B, Hu J, Li M, Cheng L, Luo H, Xie W, Liu C, Fan L, Chen W, Zhang X. A molecularly imprinted electrochemical sensor based on in- situ polymerization for rapid and selective detection of tonalide in aqueous environment. Anal Biochem. 2025 Mar;698:115730. doi: 10.1016/j.ab.2024.115730. Epub 2024 Nov 30. 363(Pt 2):125202. doi: 10.1016/j.envpol.2024.125202. Epub 2024 Oct 26. 58(17):7617-7627. doi: 10.1021/acs.est.4c01051. Epub 2024 Apr 17.
202:116353. doi: 10.1016/j.marpolbul.2024.116353. Epub 2024 Apr 10. 58(12):5524-5533. doi: 10.1021/acs.est.4c00840. Epub 2024 Mar 11.
7: Li J, Lu Y, Chen H, Zheng D, Yang Q, Campos LC. Synthetic musks in the natural environment: Sources, occurrence, concentration, and fate-A review of recent developments (2010-2023). Sci Total Environ. 2024 Apr 20;922:171344. doi: 10.1016/j.scitotenv.2024.171344. Epub 2024 Mar 1. 2(1):32-39. doi: 10.1016/j.eehl.2023.03.002.
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