专利号:US-2025082793-A1 优先权日:2021-11-09 标 题 :Macrocyclic compounds and methods of making the same 发明人:CLEATOR EDWARD; MATON WILLIAM MARC; SALTER RHYS 权利人:JANSSEN BIOTECH INC 摘要:The present invention is directed to the preparation of key intermediates and synthesis of compounds (macrocyclic compounds) and pharmaceutically acceptable salts thereof, immunoconjugates, radioimmunoconjugates thereof, pharmaceutical compositions containing said compounds and immunoconjugates, radioimmunoconjugates thereof.
专利号:US-8679854-B2 优先权日:2007-03-26 标题:Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof 发明人:PARK SEUNG BUM; CHO MYUNG HAING; LEE HYANG YEON; PARK JONG MIN 权利人:PARK SEUNG BUM; CHO MYUNG HAING; LEE HYANG YEON; PARK JONG MIN; SNU & DB FOUNDATION 摘要:The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and β anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.
专利号:US-8912323-B2 优先权日:2009-10-30 标题 :Multifunctional small molecules 发明人:BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P 权利人:BAKER JR JAMES R; ZONG HONG; THOMAS THOMMEY P; UNIV MICHIGAN 摘要:The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.
专利号:US-11970523-B2 优先权日:2018-07-25 标 题 :Long-acting oxyntomodulin hybrid peptide, preparation method therefor, and application thereof 发明人:QIAN HAI; HUANG WENLONG; CAI XINGGUANG; LI CHENGYE; LIU CHUNXIA; DAI YUXUAN 权利人:UNIV CHINA PHARMA 摘要:The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.
专利号:US-6486350-B1 优先权日:1998-09-30 标 题:Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide 发明人:AUDIA JAMES E; HYSLOP PAUL A; NISSEN JEFFREY S; THOMPSON RICHARD C; TUNG JAY S; TANNER LAURA I 权利人:ELAN PHARM INC; LILLY CO ELI 摘要:Disclosed are biological reagents which comprise compounds that inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of beta-amyloid peptide.
专利号:US-8715529-B1 优先权日:2012-01-23 标 题 :Synthesis and applications of triazaborolopyridinium compounds and substituted triazaborolopyridinium compounds and methods of use 发明人:ARTERBURN JEFFREY B; SHUSTER CHARLES B; HOUSTON KEVIN D 权利人:ARROWHEAD CT INC 摘要:The present invention is a class of fluorescent compounds derived from hydrazine-2-yl-pyridine containing a triazaborolopyridinium core. The compounds are prepared using a stepwise procedure that begins with a reaction of a hydrazinylpyridine with an aldehyde or ketone to produce a hydrazine. A general formula for the invention is
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