CAS: 130-80-3; Hex-3-Ene-3,4-Diylbis(4,1-Phenylene) Dipropionate

该化合物是一种合成雌激素,一种二乙基二乙基二乙基二丙醇的衍生物,最初是为其雌性致癌特性而开发的,其特征是能够与雌性受体结合,从而影响与生长和生殖有关的各种生物过程,通常以白色为白,以非白晶状粉为表征,在水中溶解不力,但在有机溶剂中溶解.二乙基二丙基二丙基主要用于兽医药物,特别是治疗动物的某些生殖紊乱,但是,由于担心与DES及其衍生物相关的潜在致癌影响和其他健康风险,该化合物在人类中的使用基本上已经停止.该化合物的药效包括促进女性二级性特征的发展和管理月经周期.由于其雌性活动,必须谨慎地处理该物质,遵守安全准则,以减轻任何潜在的健康风险.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

pyridine diethylstilbestrol propionic acid anhydride propionyl chloridedl-hexestrol t-eneoptically inactive 2,5-dibromo-3,4-bis-(4-propionyloxy-phenyl)-hex-3t-ene diethylstilbestrol cis-3,4-Bis(p-hydroxyphenyl)-3-hexene

合成工艺路线路线简述

    📜3,4-Bis-(4-Propionyloxy-Phenyl)-Hex-3C-Ene置于吡啶,氨体系中,化学反应生成丙酸己烯雌酚
    参考文献:ber Krperfremde Synthetische strogene
    标题:ber Krperfremde Synthetische strogene
    摘要:
    Doi:10.1007/bf00898697

    海关参考信息

    专利信息


    专利号:EP-0614894-A1
    优先权日:1993-03-12
    标 题 :Process for the synthesis of substituted amide derivatives of piperazinylcamphorsulfonyl oxytocin antagonists

    专利号:US-6090805-A
    优先权日:1997-06-18
    标 题 :Tocolytic oxytocin receptor antagonists
    发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; PERLOW DEBRA S; STAUFFER KENNETH; FREIDINGER ROGER M
    权利人:MERCK & CO INC
    摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

    专利号:WO-9725992-A1
    优先权日:1996-01-16
    标 题 :Tocolytic oxytocin receptor antagonists
    发明人:SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D
    权利人:MERCK & CO INC; SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D
    摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

    专利号:US-5726172-A
    优先权日:1996-01-16
    标题 :Tocolytic oxytocin receptor antagonists
    发明人:SPARKS MICHELLE A; FREIDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D
    权利人:MERCK & CO INC
    摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery. A typical compound is as follows:

    专利号:US-5968938-A
    优先权日:1997-06-18
    标 题 :Piperazine oxytocin receptor antagonists
    发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; GUARE JR JAMES P; FREIDINGER ROGER M
    权利人:MERCK & CO INC
    摘要:This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

    专利号:US-5756497-A
    优先权日:1996-03-01
    标题 :Tocolytic oxytocin receptor antagonists
    发明人:BELL IAN M; FREIDINGER ROGER M; WILLIAMS PETER D
    权利人:MERCK & CO INC
    摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Hsieh TF, Tseng CJ, Tang JB, Chen YH. A proline rich acidic protein PRAP identified from uterine luminal fluid of estrous mice is able to enhance the estrogen responsiveness of Ishikawa cells. J Cell Biochem. 2011 Nov;112(11):3122-8. doi: 10.1002/jcb.23238. Japanese. Japanese. Erratum in: Horm Behav 1997 Aug;32(1):69. Russian.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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