专利号:EP-0614894-A1 优先权日:1993-03-12 标 题 :Process for the synthesis of substituted amide derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
专利号:US-6090805-A 优先权日:1997-06-18 标 题 :Tocolytic oxytocin receptor antagonists 发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; PERLOW DEBRA S; STAUFFER KENNETH; FREIDINGER ROGER M 权利人:MERCK & CO INC 摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
专利号:WO-9725992-A1 优先权日:1996-01-16 标 题 :Tocolytic oxytocin receptor antagonists 发明人:SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D 权利人:MERCK & CO INC; SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D 摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
专利号:US-5726172-A 优先权日:1996-01-16 标题 :Tocolytic oxytocin receptor antagonists 发明人:SPARKS MICHELLE A; FREIDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D 权利人:MERCK & CO INC 摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery. A typical compound is as follows:
专利号:US-5968938-A 优先权日:1997-06-18 标 题 :Piperazine oxytocin receptor antagonists 发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; GUARE JR JAMES P; FREIDINGER ROGER M 权利人:MERCK & CO INC 摘要:This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
专利号:US-5756497-A 优先权日:1996-03-01 标题 :Tocolytic oxytocin receptor antagonists 发明人:BELL IAN M; FREIDINGER ROGER M; WILLIAMS PETER D 权利人:MERCK & CO INC 摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.