CAS: 1206977-80-1; 2-Chloro-3-(Difluoromethoxy)Pyridine

相似化合物

1206980-39-3 1214349-42-4 1221171-72-7

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2-氯-3-羟基吡啶 2-Chloro-3-Hydroxypyridine 6636-78-8

📜三氟甲烷,2-氯-3-羟基吡啶置于potassium Hydroxide体系中,用 水,乙腈 用作溶剂,化学反应 3.5H,以51%的收率获得2-氯-3-(二氟甲氧基)吡啶
参考文献:Use Of Fluoroform As A Source Of Difluorocarbene In The Synthesis Of N-Cf 2 H Heterocycles And Difluoromethoxypyridines
标题:Use Of Fluoroform As A Source Of Difluorocarbene In The Synthesis Of N-Cf 2 H Heterocycles And Difluoromethoxypyridines
摘要:Fluoroform Is Used As A Source Of Difluorocarbene To Convert Various N-,O-,And C-Nucleophiles To Their Difluoromethylated Derivatives. Imidazole,Benzimidazole,Benztriazole,Hydroxypyridines,And Their Derivatives Underwent Reaction At Moderate Temperatures And Atmospheric Pressure,Using Potassium Hydroxide As Base In A Two-Phase (Water/acetonitrile) Process To Provide Moderate To Good Yields Of The Respective Products. Nitrophenols Required Addition Of A Co-Solvent (Methanol) To Obtain Good Yields Of Products. (C) 2014 Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Jfluchem.2014.08.015