CAS: 91531-30-5; (S)-N-(2,6-Dioxopiperidin-3-yl)-2-Phenylacetamide
该化合物是一种化学化合物,具有特定的立体化学和功能组的特点,具有管状环,代之以苯乙基胺,有助于其潜在的生物活动.2,6二氧组的存在表明,它可能参与各种化学反应,特别是涉及核素或电击的化学反应.这种化合物可能表现出亚胺的典型特性,例如氢联结能力,它可以影响其溶性以及与生物目标的相互作用.此外,立体化学学(S配置)表明,它可能在生物系统中有特定的相互作用,有可能影响其药理学特征.
- 英文名称(S)-N-(2,6-Dioxopiperidin-3-yl)-2-Phenylacetamide
- 中文名称3-苯基乙酰氨基-2,6-哌啶二酮
- IUPAC名称(S)-N-(2,6-dioxopiperidin-3-yl)-2-phenylacetamide
- 其它别名Antineoplaston A10; Antineoplaston A 10; N-[(3S)-2,6-Dioxopiperidin-3-Yl]-2-Phenylacetamide; Atengenal; 16Vy3Tm7Zo; Antineoplaston-A10; (S)-N-(2,6-Dioxopiperidin-3-yl)-2-Phenylacetamide; Benzeneacetamide, N-(2,6-Dioxo-3-Piperidinyl)-, (S)-; A 10; Unii-1
- CAS编号91531-30-5
- MFCD编号:MFCD26961095
- FDA UNII编号:16VY3TM7ZO
- 分子式:C13H14N2O3分子量:246.27
- 产品CID: 1952060
- 产品分类生物 → 细胞培养 → 细胞系
物理性质
合成工艺路线路线简述
📜苯乙酰氯,Dl-谷氨酰胺 反应生成 3-苯基乙酰氨基-2,6-哌啶二酮
参考文献:Purified Antineoplaston Fractions And Methods Of Treating Neoplastic
标题:Purified Antineoplaston Fractions And Methods Of Treating Neoplastic
摘要:本文介绍了从人类尿液中高度纯化的分离物,具有抗肿瘤活性和制备过程.这些分离物包括生物活性,小分子量的低分子量肽,对肿瘤细胞培养和人类肿瘤疾病表现出细胞毒和细胞抑制活性.这些分离物被称为抗肿瘤素分离物.一种存在于各种抗肿瘤素分离物中的抗肿瘤活性肽已被分离和鉴定为3-[n-苯乙酰氨基哌啶]-2,6-二酮.还披露了一种合成3-[n-苯乙酰氨基哌啶]-2,6-二酮的机制,涉及l-谷氨酰胺和苯乙酰氯之间的组合反应.此外,还披露了3-[n-苯乙酰氨基哌啶]-2,6-二酮的水解降解产物,当按照本公开的一般教导进行给药时,也表现出抗肿瘤活性.
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6787668-B2
优先权日:2000-04-13
标 题 :2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
发明人：PITZELE BARNETT S; SIKORSKI JAMES A; WEBBER RONALD KEITH
权利人:PHARMACIA CORP
摘要:The present invention is directed to a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:R1 is selected from the group consisting of H and methyl; andR2 is selected from the group consisting of H and methyl.The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.
专利号:EP-0069232-B1
优先权日:1981-07-02
标题 :Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione
专利号:EP-0069232-A2
优先权日:1981-07-02
标题 :Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Qu XJ, Cui SX, Tian Z, Li X, Chen MH, Xu WF, Inagaki Y, Deng YB, Makuuchi M, Nakata M, Tang W. Induction of apoptosis in human hepatocellular carcinoma cells by synthetic antineoplaston A10. Anticancer Res. 2007 Jul-Aug;27(4B):2427-31. Japanese. doi: 10.1371/journal.pone.0120064.
14: Michalska D. Theoretical investigations on the structure and potential binding sites of antineoplaston A10 and experimental findings. Drugs Exp Clin Res. 1990;16(7):343-9.
合成参考文献
摘要:AUBEL G. [Action of carbohydrates and related compound on human isohemagglutinins beta(A10) and alpha(BO)]. Bull Soc Chim Biol (Paris). 1958;40(5-6):807–14.
参考文献:10.1177/1534735404267748
摘要:Burzynski SR, Lewy RI, Weaver R, Janicki T, Jurida G, Khan M, Larisma CB, Paszkowiak J, Szymkowski B. Long-term survival and complete response of a patient with recurrent diffuse intrinsic brain stem glioblastoma multiforme. Integr Cancer Ther. 2004 Sep;3(3):257–61. doi: 10.1177/1534735404267748.
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