CAS: 89-97-4; (2-Chlorophenyl)Methanamine

• 英文名称(2-Chlorophenyl)Methanamine
• 中文名称2-氯苄胺
• IUPAC名称(2-chlorophenyl)methanamine
• 其它别名2-氯苯甲基胺; 2氯苄胺; 2-Chlorobenzylamine
• CAS编号89-97-4
• MFCD编号:MFCD00008108
• EINECS号:201-955-8
• FDA UNII编号:L790J4Y7A3
• 分子式:C7H8ClN
• 分子量:141.6
• 产品CID: 1929976
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• InChIKey: KDDNKZCVYQDGKE-UHFFFAOYSA-N
• InChI=1S/C7H8ClN/c8-7-4-2-1-3-6(7)5-9/h1-4H,5,9H2…
• 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数1.0

物理性质

• 熔点227-228 °C
• 沸点103-104°C at 11 mmHg
• 闪点90°C
• 密度1.2±0.1 g/cm3
• pKa:8.52±0.10(预测)
• PSA:26.02
• LogP:1.7987
• 折射率1.566
• 蒸汽压0.1±0.4 mmHg at 25°C
• 敏感性空气敏感
• 外观形态透明黄色液体
• 储存条件请置于阴暗处, 惰性气氛中,2-8°C
• 产品应用医药中间体,聚氨酯催化剂.
• 性质描述密度1.17,沸点103-104°C(11torr),折射率1.562-1.564,闪点88°C

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS05;
  注释: Exclamation mark & Corrosion
• 危险类别急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  皮肤腐蚀 类别1B
  皮肤腐蚀 类别1C
  急性毒性 类别3(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼损伤 类别1
• 警示词Danger(危险)
• 危险描述H312 |皮肤接触有害.
  H302 |吞咽有害.
  H314 |造成严重皮肤灼伤和眼损伤.
  H301 |吞咽会中毒.
  H336 |可能引起嗜睡或头晕.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H335 |可能引起呼吸道刺激.
  H318 |造成严重眼损伤.
• 防范说明P210-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501
• 危险等级8
• UN编号2735.0
• 危险品标志C,Xi
• 风险等级Irritant
• 包装等级Ⅱ
• 安全声明26-36/37/39-45-36
• 危险类别码36/37/38-34-37
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-Chlorobenzylamine 主要起始原料 2-Chlorobenzyl Chloride
• 89-98-5 = 89-97-4
  反应条件:1.1 Reagents: Hydrogen,Ammonium Hydroxide Catalysts: Nickel (Silica-Supported Iron Oxide) Solvents: Ethanol; 20 Bar,Rt; 2 H,20 Bar,115 °C
  标题:Microwave-Assisted Reductive Amination With Aqueous Ammonia: Sustainable Pathway Using Recyclable Magnetic Nickel-Based Nanocatalyst
  作者:Manzoli,Maela; Gaudino,Emanuela Calcio; Cravotto,Giancarlo; Tabasso,Silvia; Baig,R. B. Nasir; Et Al
  参考文献:Acs Sustainable Chemistry & Engineering 日期:2019 卷标:7(6) 页码:5963-5974]
  
  3717-28-0 = 89-97-4
  反应条件:1.1 Reagents: Sodium Nitrite,Tetrafluoroboric Acid Catalysts: 4-Nitro-1,2-Phenylenediamine Solvents: Water; Rt; 1 H,0 °C1.2 Catalysts: Potassium Tetrachloropalladate Solvents: Toluene,Water; 1 H,0 °C1.3 Reagents: Sodium Borohydride Solvents: Water; 2 H,Rt1.4 Reagents: Hydrogen Solvents: Water; 3 H,Ph 9,1 Atm,Rt
  标题:Heterogeneous Palladium-Based Catalyst Promoted Reduction Of Oximes To Amines: Using H2 At 1 Atm In H2O Under Mild Conditions
  作者:Liu,Yaxu; Quan,Ziyi; He,Shaopo; Zhao,Zexi; Wang,Jiang; Et Al
  参考文献:Reaction Chemistry & Engineering 日期:2019 卷标:4(6) 页码:1145-1152]
  
  89-98-5 = 89-97-4
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Cobalt (Graphene-Encapsulated) Solvents: Methanol; 4 H,2 Mpa,90 °C
  标题:Facile Manner In Regulating The Graphene-Shelled Structure Of Cobalt Nanoparticles For The Synthesis Of Amines
  作者:Zhuang,Xiuzheng; Liu,Jianguo; Ma,Longlong
  参考文献:Chemrxiv 日期:2021 卷标:1 页码:1-15]
  
  89-98-5 = 89-97-4
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Boride (Ni2B) (Supported On Ts-1 Mol. Sieve) Solvents: Isopropanol; 0.5 Mpa,Rt -> 120 °C; 2 H,4 Mpa,120 °C
  标题:General Construction Of Amine Via Reduction Of N=x (X = C,O,H) Bonds Mediated By Supported Nickel Boride Nanoclusters
  作者:Ke,Da; Zhou,Shaodong
  参考文献:International Journal Of Molecular Sciences 日期:2022 卷标:23(16)]
  
  = 89-97-4
  反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Nickel Dichloride Solvents: Water; 1 H,95 °C
  标题:Chemo-Selective Reduction Of Nitro And Nitrile Compounds Using Ni Nanoparticles Immobilized On Hyperbranched Polymer-Functionalized Magnetic Nanoparticles
  作者:Tabatabaei Rezaei,Seyed Jamal; Mashhadi Malekzadeh,Asemeh; Poulaei,Sima; Ramazani,Ali; Khorramabadi,Hossein
  参考文献:Applied Organometallic Chemistry 日期:2018 卷标:32(1)]
  
  611-19-8 = 89-97-4 [标题:Reaction Conditions
  标题:Manufacture Of Benzylamines From Benzyl Chlorides And Hexamethylenetetramine
  参考文献:Japan]
  
  = 89-97-4
  反应条件:1.1 Reagents: Silver Acetate,(2-Bromoethynyl)Tris(1-Methylethyl)Silane,[1,1,1-Trifluoro-N-[(Trifluoromethyl)Sulfonyl-Ko]Methanesulfonamidato-Ko]Silver Catalysts: Iridium,Di-μ-Chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-Pentamethyl-2,4-Cyclopen... Solvents: 1,2-Dichloroethane,Pyridine,Acetic Acid-D4; 4 H,70 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Catalytic C-H Alkynylation Of Benzylamines And Aldehydes With Aldimine-Directing Groups Generated In Situ
  作者:Zhou,Jiao; Jiao,Tenggang; Fu,Qiang; Wang,Jun; Lu,Ji; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2023 卷标:59(42) 页码:6355-6358]
  
  17849-38-6 = 89-97-4
  反应条件:1.1 Reagents: Tosyl Chloride,Zinc,Zinc Chloride,Sodium Azide; 30 Min,65 °C; 65 °C -> Rt1.2 Reagents: Water; 10 Min,Rt
  标题:One-Pot Conversion Of Alcohol To Amine Using Sodium Azide With Zinc And Zinc Chloride
  作者:Patil,Dinanath D.; Mhaske,Dnyandeo K.; Wadhawa,Gurumeet C.; Patare,Machindra A.
  参考文献:Journal Of Pharmaceutical Research And Opinion 日期:2011 卷标:1(6) 页码:170-171]
  
  89-98-5 = 89-97-4
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Cobalt,Graphene Solvents: Methanol; 4 H,2 Mpa,90 °C
  标题:A General Synthesis Of Amines Via Cobalt Atoms Individually Anchored By Divacancy Sites On Graphene-Shelled Layers
  作者:Zhuang,Xiuzheng; Liu,Jianguo; Ji,Yangqi; Wu,Xiaojun; Zhang,Xinghua; Et Al
  参考文献:Chem Catalysis 日期:2023 卷标:3(8)]
  
  = 89-97-4
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Iron Oxide (Fe2O3),Iron Solvents: Isopropanol; 24 H,50 Bar,120 °C
  标题:Silica-Supported Fe/fe-O Nanoparticles For The Catalytic Hydrogenation Of Nitriles To Amines In The Presence Of Aluminium Additives
  作者:Chandrashekhar,Vishwas G.; Senthamarai,Thirusangumurugan; Kadam,Ravishankar G.; Malina,Ondrej; Kaslik,Josef; Et Al
  参考文献:Nature Catalysis 日期:2022 卷标:5(1) 页码:20-29]
  
  = 89-97-4
  反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Iron Oxide (Fe3O4),Carbon (Acidified,Carboxylated),(Sp-4-3)-Dichloro(1,7-Phenanthroline-Kn7)[1,1′-(Sulfinyl-Ks)Bis[methane]]Platinu... Solvents: Water; 15 Min,25 °C
  标题:Chemoselective Reduction Of Nitro And Nitrile Compounds With Magnetic Carbon Nanotubes-Supported Pt(Ii) Catalyst Under Mild Conditions
  作者:Tabatabaei Rezaei,Seyed Jamal; Khorramabadi,Hossein; Hesami,Ali; Ramazani,Ali; Amani,Vahid; Et Al
  参考文献:Industrial & Engineering Chemistry Research 日期:2017 卷标:56(43) 页码:12256-12266]
  
  89-98-5 = 89-97-4
  反应条件:1.1 Reagents: Ammonium Acetate,Hydrogen,Ammonia Catalysts: (Oc-6-33)-Bis(Glycinato-Kn,Ko)[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-K... Solvents: Isopropanol; 18 H,50 Bar,130 °C
  标题:Easily Synthesized Ru Catalyst Efficiently Converts Carbonyl Compounds And Ammonia Into Primary Amines
  作者:Pan,Jia-Sheng; Zhang,Rui; Ma,Shuang-Shuang; Han,Li-Jun; Xu,Bao-Hua
  参考文献:Chemistryselect 日期:2020 卷标:5(35) 页码:10933-10938]
  
  = 89-97-4
  反应条件:1.1 Reagents: Hydrogen Catalysts: Stereoisomer Of [n-[3-[bis(1,1-Dimethylethyl)Phosphino-Kp]Propyl]-1-Methyl-1H-Im... Solvents: Isopropanol; 3 H,30 Bar,50 °C
  标题:Nnp-Type Pincer Imidazolylphosphine Ruthenium Complexes: Efficient Base-Free Hydrogenation Of Aromatic And Aliphatic Nitriles Under Mild Conditions
  作者:Adam,Rosa; Alberico,Elisabetta; Baumann,Wolfgang; Drexler,Hans-Joachim; Jackstell,Ralf; Et Al
  参考文献:Chemistry - A European Journal 日期:2016 卷标:22(14) 页码:4991-5002]
  
  89-98-5 = 89-97-4
  反应条件:1.1 Reagents: Ammonia Catalysts: Potassium Tetrachloropalladate Solvents: Water; 5 Min,Ph 3,Rt1.2 Reagents: Hydrogen; 6 H,0.1 Mpa,Rt
  标题:Study On Preparation Of Palladium (0) Catalyst By Diazotization And Its Application In Synthesis Of Aromatic Amines
  作者:Wu,An-Qi; Liu,Si-Xin; Wang,Gui-Ping; Wang,Bo
  参考文献:Fenzi Cuihua 日期:2021 卷标:35(1) 页码:40-47]
  
  63777-70-8 = 89-97-4
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium (Silk-Fibroin Supported) Solvents: Methanol; 24 H,1 Atm,Rt
  标题:Highly Chemoselective Hydrogenation Method Using Novel Finely Dispersed Palladium Catalyst On Silk-Fibroin: Its Preparation And Activity
  作者:Ikawa,Takashi; Sajiki,Hironao; Hirota,Kosaku
  参考文献:Tetrahedron 日期:2005 卷标:61(8) 页码:2217-2231]
  
  63777-70-8 = 89-97-4
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium (Silk Fibroin-Supported) Solvents: Methanol; 24 H,Rt
  标题:Preparation Of Silk Fibroin-Supported Pd(0) Catalyst For Chemoselective Hydrogenation: Reduction Of Palladium(Ii) Acetate By Methanol On The Protein
  作者:Sajiki,Hironao; Ikawa,Takashi; Yamada,Hiromi; Tsubouchi,Kozo; Hirota,Kosaku
  参考文献:Tetrahedron Letters 日期:2003 卷标:44(1) 页码:171-174]
  
  17849-38-6 = 89-97-4
  反应条件:1.1 Reagents: Tosyl Chloride,Zinc,Iron Chloride (Fecl3),Sodium Azide; 30 Min,65 °C; 65 °C -> Rt1.2 Reagents: Water; 10 Min,Rt
  标题:One-Pot Conversion Of Alcohol To Amine With Zinc And Ferric Chloride
  作者:Dinanathpatil; Wadhava,Gurumeet; Deshmukh,Arun K.
  参考文献:Journal Of Pharmaceutical Research And Opinion 日期:2011 卷标:1(3) 页码:96-97

海关参考信息

• 2902300000-甲苯
  2903919090-氯苯
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管