CAS: 8015-18-7; 4-Dimethylamino-1,5-Dimethyl-2-Phenyl-1,2-Dihydro-Pyrazol-3-One; Compound With 3,3-Diethyl-1H-Pyridine-2,4-Dione

📜5,5-二乙基丙二酰脲,氨基比林置于水体系中,化学反应生成 2-羟基缬草酸,盐水合物钠
参考文献:Pfeiffer,Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie,1925,Vol. 146,P. 100
标题:Pfeiffer,Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie,1925,Vol. 146,P. 100

专利信息

专利号:US-2003050305-A1
优先权日:2000-05-22
标题:Thromboxane inhibitors, compositions and methods of use
发明人：TEJADA INIGO SAENZ DE
摘要:The present invention describes methods for treating or preventing sexual dysfunctions in males and females, and for enhancing sexual responses in males and females by administering a therapeutically effective amount of at least one thromboxane inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The male or female may preferably be diabetic. The present invention also provides novel compositions comprising at least one thromboxane inhibitor, and, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and, optionally, at least one therapeutic agent, such as, vasoactive agents, nonsteroidal antiinflanmmatory compounds (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, anticoagulants, angiotensin converting enzymes (ACE) inhibitors, angiotensin II receptor antagonists, renin inhibitors, and mixtures thereof. The present invention also provides methods for treating or preventing ischemic heart disorders, myocardial infarction, angina pectoris, stroke, migraine, cerebral hemorrhage, cardiac fatalities, transient ischaemic attacks, complications following organ transplants, coronary artery bypasses, angioplasty, endarterectomy, atherosclerosis, pulmonary embolism, bronchial asthma, bronchitis, pneumonia, circulatory shock of various organs, nephritis, graft rejection, cancerous metastases, pregnancy-induced hypertension, preeclampsia, eclampsia, thrombotic and thromboembolic disorders, intrauterine growth, gastrointestinal disorders, renal diseases and disorders, disorders resulting from elevated uric acid levels and dysmenorrhea, and for inhibiting platelet aggregation or platelet adhesion or relaxing smooth muscles.

专利号:US-7432285-B2
优先权日:1999-12-23
标 题 :Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
发明人：BANDARAGE RAMANI R; BANDARAGE UPUL K; FANG XINQIN; GARVEY DAVID S; LETTS L GORDON; SCHROEDER JOSEPH D; TAM SANG W
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.

专利号:RU-2126413-C1
优先权日:1992-10-01
标题:Phospholipid derivatives, a method of their synthesis, a pharmaceutical composition based on said, methods of a pharmaceutical composition preparing

专利号:SU-806106-A1
优先权日:1977-01-04
标 题 :Method of catalyst for carbon oxide conversion or methanol synthesis

专利号:ES-2200734-T3
优先权日:1999-02-02
标题:PROCEDURE FOR THE PREPARATION OF A METHANOL7DIMETIL ETER MIXTURE FROM SYNTHESIS GASES.