CAS: 7368-78-7; 4-Bromo-2-Methoxyphenol

上下游产品

2-methoxy-phenol 2-benzyloxy-5-bromoanisole 4-bromo-1-isopropoxy-2-methoxy-benzene 4-bromo-2-methoxyphenyl acetate methoxyhydroquinone 4-bromo-2-methoxy-6-nitrophenol 4-bromo-2-methoxyphenyl acetate 2-benzyloxy-5-bromoanisole

木榴油置于n-Benzyl-N,N-Dimethyl Anilinium Peroxodisulfate,Potassium Bromide体系中,用 乙腈 作为反应溶剂,化学反应 3.5H,以96%的收率获得产物4-溴邻甲氧基苯酚
参考文献:Simple And Improved Regioselective Brominations Of Aromatic Compounds Using N-Benzyl N,N-Dimethyl Anilinium Peroxodisulfate In The Presence Of Potassium Bromide Under Mild Reactions Conditions
标题:Simple And Improved Regioselective Brominations Of Aromatic Compounds Using N-Benzyl N,N-Dimethyl Anilinium Peroxodisulfate In The Presence Of Potassium Bromide Under Mild Reactions Conditions
摘要:利用 N-苄基 N,N-二甲基铵选择性溴化某些活化芳香族化合物的简单,高效和温和方法 使用 N-苄基 N,N-二甲基苯胺鎓在非水溶液中进行选择性溴化某些活性芳香族化合物的简单,高效,温和的方法. 在非水溶液中,使用 N-苄基 N,N-二甲基茴香硫酸盐在溴化钾存在下选择性溴化某些活化芳香族化合物的简单,高效,温和的方法 对一些活化的芳香族化合物进行溴化.研究结果表明 在苯酚和甲氧基烯的正对位和对位之间具有非常好到卓越的选择性.
DOI:10.2298/jsc100212058G

专利信息

专利号:US-8975431-B2
优先权日:2010-05-19
标 题 :Process for preparing an ortho-substituted 5-halophenol and a synthesis intermediate thereof
发明人：MERCIER CLAUDE; DE CAMPO FLORYAN; RIGHINI SÉBASTIEN
权利人:MERCIER CLAUDE; DE CAMPO FLORYAN; RIGHINI SÉBASTIEN; RHODIA OPERATIONS; SOLVAY CHINA CO LTD
摘要:A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:WO-0050406-A1
优先权日:1999-02-22
标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAEL
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.

专利号:CN-109666030-A
优先权日:2018-11-19
标题:A method for catalyzing asymmetric synthesis of codeine and morphine

专利号:US-2019002448-A1
优先权日:2015-12-31
标 题 :Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (I) or (II), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.