CAS: 728-81-4; Phenyl(3-(Trifluoromethyl)Phenyl)Methanone

上下游产品

3-(trifluoromethyl)benzhydrol 3-(Trifluoromethyl)benzoyl chloride benzene 3-trifluoromethylbenzonitrile α-ethenyl-α-phenyl-3-(trifluoromethyl)benzenemethanol 3-(trifluoromethyl)benzhydrol 3,3''-Bis-trifluormethyl-benzpinakon -1-phenyl-1--aethylen2-3,4-Dichlor-phenyl-1-phenyl-1-3-trifluormethyl-phenyl-aethylen

📜3-(三氟甲基)苯甲酰氯置于4-二甲氨基吡啶,氯化亚砜,[pd(Ipr)(Cin)Cl],Potassium Carbonate,三乙胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 30.0H,反应生成 3-(三氟甲基)苯甲酮
参考文献:N-酰基吡咯和吡唑的suzuki-Miyaura交叉偶联:催化n-C裂解中的平面电子活化酰胺
标题:N-酰基吡咯和吡唑的suzuki-Miyaura交叉偶联:催化n-C裂解中的平面电子活化酰胺
摘要:迄今为止,由于空间扭曲,通过酰胺键的催化活化作用由酰胺形成c-c键是可能的.本文中,我们报道了一般的pd催化的suzuki-Miyaura平面酰胺交叉偶联的第一个例子,该偶联可通过以下方式组合实现:(i)电子活化n-酰基吡咯和吡唑中的酰胺氮,以及(II)使用多功能的pd-Nhc催化平台.讨论了形成酰基金属的起源和选择性,包括扭曲的作用.
DOI:10.1021/acs.Orglett.7B01575

专利信息

专利号:US-4453012-A
优先权日:1982-04-22
标 题 :Process for the preparation of phenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.