CAS: 71058-35-0; N-(2,6-Dimethylphenyl)Hydrazinecarbothioamide

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CAS号75-15-0 二硫化碳 | CAS号87-62-7 2,6-二甲基苯胺 | CAS号80650-19-7 N-(2,6-dimethyl...

📜Potassium (2,6-Dimethylphenyl)Carbamodithioate置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 1.0H,反应生成 4-(2,6-二甲基苯基)-3-氨基硫脲
参考文献:5-Nitrofuran-2-Yl Derivatives: Synthesis And Inhibitory Activities Against Growing And Dormant Mycobacterium Species
标题:5-Nitrofuran-2-Yl Derivatives: Synthesis And Inhibitory Activities Against Growing And Dormant Mycobacterium Species
摘要:Eighteen 5-Nitrofuran-2-Yl Derivatives Were Prepared By Reacting 5-Nitro-2-Furfural With Various (Sub)Phenyl/pyridyl Thiosemicarbazide Using Microwave Irradiation. The Compounds Were Tested For Their In Vitro Activity Against Tubercular And Various Non-Tubercular Mycobacterium Species In Log-Phase And 6-Week-Starved Cultures. Compound N-(3,5-Dibromopyridin-2-yl)-2-((5-Nitrofuran-2-yl) Methylene) Hydrazinecarbothioamide (4R) Was Found To Be The Most Potent Compound (Mic: 0.22 Mu M) And Was 3 Times More Active Than Standard Isoniazid (Inh) And Equally Active As Rifampicin (Rif) In Log-Phase Culture Of Mycobacterium Tuberculosis H37Rv. In Starved M. Tuberculosis H37Rv,4R Inhibited With Mic Of 13.9 Mu M And Was Found To Be 50 Times More Active Than Inh And Slightly More Active Than Rif. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2008.12.088