CAS: 701-70-2; 1-Phenylbutan-2-Ol

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2-Ethyl-3-Phenyloxirane置于cobalt(II) Bis[bis((Trifluoromethyl)Sulfonyl)Amide],氢气,Zinc Trifluoromethanesulfonate,1,1,1-三(二苯基膦甲基)乙烷体系中,用 四氢呋喃 作为反应溶剂,80.0 °C,4.0 Mpa 条件下,反应 16.0H,以93%的收率获得产物乙基苯乙醇
参考文献:通过钴的环氧催化加氢,一般区域选择性合成醇.
标题:通过钴的环氧催化加氢,一般区域选择性合成醇.
摘要:提出了一种简单的合成抗马尔可夫尼可夫醇的方法.通过在zn(otf)2作为添加剂的情况下使用特定的钴三光配合物,可以高收率和选择性地进行环氧化物的氢化.所描述的方案显示了广泛的底物范围,包括多取代的内部和末端环氧化物,以及非常好的官能团耐受性.各种天然产物衍生物,包括类固醇,萜类和倍半萜类,都以中等至优异的产率获得了相应的醇.
DOI:10.1002/anie.202002844

专利信息

专利号:US-6376649-B1
优先权日:1998-12-18
标题 :Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
发明人：SEMPLE JOSEPH E; LEVY ODILE E
权利人:CORVAS INT INC
摘要:Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-alpha-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl alpha-ketoamides and alpha-hydroxy-beta-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases.

专利号:US-2015197503-A1
优先权日:2012-07-27
标题 :Process for the synthesis of substituted urea compounds
发明人：RUSSO DOMENICO; WAHNON JORGE BRUNO REIS; MATON WILLIAM; ESZENYI TIBOR
权利人:BIAL PORTELA & Cª S A
摘要:A process for preparing a substituted urea compound of Formula II or Formula I, or a pharmaceutically acceptable salt or ester thereof, Formula II, Formula I the process comprising the reaction of an intermediate of Formula II′ or Formula 1′, Formula II′, Formula I′ with a carbamoyl halide of the formula: R1R2NC(=0)Hal, in a solvent consisting essentially of pyridine, wherein Hal represents Cl, F, I or Br, and wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

专利号:US-4874558-A
优先权日:1987-05-21
标 题:Polymer catalyzed synthesis of acid anhydrides
发明人：FIFE WILMER K; ZHANG ZHI-DONG
权利人:INDIANA UNIVERSITY FOUNDATION
摘要:Solid-phase copolymers of 4-vinylpyridine or 4-vinylpyridine 1-oxide may be employed as catalysts in the formation of acid anhydrides. A water soluble polymer of 4-vinylpyridine 1-oxide may also be employed as a catalyst in the formation of acid anhydrides.

专利号:US-5770752-A
优先权日:1995-12-18
标题 :Process for reducing the concentration of by-products in product mixtures
发明人：KAUFMANN WILHELM; WISSER THOMAS; STREB JOHANN; RINK THOMAS; ZENK ROLAND; RIEDEL MICHAEL; CABRERA IVAN
权利人:TARGOR GMBH
摘要:The present invention relates to a process for reducing the concentration of organometallic and/or inorganic by-products in product mixtures formed in the synthesis of metallocenes, which comprises treating a mixture comprising one or more metallocenes and one or more organometallic and/or inorganic by-products with a polar extractant.

专利号:US-6710185-B2
优先权日:2000-09-20
标 题 :Process for the preparation of cell proliferation inhibitors
发明人：GUPTA ASHOK K; KING STEVEN A; LEE ELAINE C; MORTON HOWARD E; PLATA DANIEL J; PU YU-MING; SHARMA PADAM N
权利人:ABBOTT LAB
摘要:The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors.

专利号:US-2002128496-A1
优先权日:2001-01-12
标题 :Process for the preparation of matrix metalloproteinase inhibitors
发明人：CHANG SOU-JENG; FERNANDO DILINIE P; GUPTA ASHOK; HILL DAVID R; WITTENBERGER STEVEN J
摘要:The present invention discloses a process for the synthesis of reverse hydroxamate matrix metalloproteinase (MMP) inhibitors.