CAS: 58725-39-6; Dodecanoyl-L-Proline

上下游产品

N-succinimidyl laurate L-prolineL-proline lauric acid rac-Pro-OH

📜月桂酸置于三乙胺,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 25.0H,反应生成 N-十二碳酰基-L-脯氨酸
参考文献:Luliberin Analogues Exhibiting A Cytotoxic Effect On Tumor Cells In Vitro
标题:Luliberin Analogues Exhibiting A Cytotoxic Effect On Tumor Cells In Vitro
摘要:Luliberin Analogues Modified At The N-Terminus Were Synthesized To Search For Drugs Exerting A Cytotoxic Effect On Cells Of Hormone-Dependent Tumors. A Synthetic Scheme Effective In The Preparation Of Analogues Containing Fatty Acid Residues Was Proposed. The Cytotoxic Effect Of The Peptides Was Studied On A Number Of Cell Lines Of Human Tumors In Vitro. The Dependence Of The Antitumor Effect On The Length Of Peptide Chain,Amino Acid Sequence,And Structure Of The N-Terminal Group Was Demonstrated. Modification With Palmitic Acid Was Found To Result In Highly Active Compounds In The Case Of Analogues Containing More Than Ten Aa,Whereas Modifications With Lauric,Caproic,Or Trimethylacetic Acid Led To Compounds With Significantly Lower Activities. Analogues Of Luliberin Containing A Palmitic Acid Residue And Effectively Inhibiting The Growth Of Tumor Cells In Vitro Were Synthesized.
DOI:10.1134/s1068162006050037

专利信息

专利号:US-2020123103-A1
优先权日:2017-05-12
标 题 :Method for the synthesis of an n-acyl compound without the use of organic solvent or acid chloride

专利号:US-6090250-A
优先权日:1993-09-20
标题 :Chiral surfactants and methods for their use in chiral separations
发明人：MAZZEO JEFFREY R; GROVER EDWARD R; SWARTZ MICHAEL E; MERION MICHAEL; PETERSEN JOHN S
权利人:WATERS INVESTMENTS LTD
摘要:PCT No. PCT/US94/10655 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08529 PCT Pub. Date Mar. 30, 1995Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having the general formula: is described, R1 is the hydrophobic tail, Y-A-X is the linker, the brackets define a chiral center, and the hydrophilic head group is Z. All the various components may potentiate the enantioselectivity of the chiral surfactant. The capillary electrophoresis (CE) system includes a narrow diameter capillary, a high voltage power supply, an electrolyte reservoir at each end of the capillary, a means for injecting a sample, and a detector. Chiral surfactants are dissolved in the electrolyte above their critical micelle concentration (cmc), resulting in the formation of chiral micelles. The electrolyte reservoirs and capillary tube are filled with the electrolyte. A sample containing a mixture of enantiomers is then injected into the capillary, and a high voltage potential is applied across the capillary. The sample components migrate through the capillary due to the influence of the applied electric field. An example separation of the four sereoisomers of aspartame is shown.

专利号:US-2015183823-A1
优先权日:2009-04-17
标题:Cosmetic or pharmaceutical compositions including tripeptides capable of stimulating cyclic adenosine monophosphate synthesis and their use in the treatment and/or care of the skin and/or hair

专利号:US-2017101438-A1
优先权日:2009-04-17
标题:Cosmetic or pharmaceutical methods for the treatment and/or care of the skin and/or hair using tripeptides capable of stimulating cyclic adenosine monophosphate synthesis

专利号:CN-101538236-A
优先权日:2009-05-08
标 题:Synthesis method and application of lauroyl prolyl amino acid methyl ester as a novel penetration enhancer