CAS: 5305-45-3; 4,6-Dichloropyrimidine-5-Carbonitrile

相似化合物

5305-40-8 87600-98-4 16357-68-9

上下游产品

CAS号7660-48-2 (NE)-N-[(4,6-di... | CAS号911461-47-7 4,6-二氯嘧啶-5-甲酰胺 | CAS号5305-43-1 4-chloro-6-hydr... | CAS号5305-40-8 4,6-二氯-5-嘧啶甲醛 | CAS号60025-09-4 4-氨基-6-氯嘧啶-5-甲腈

4,6-二氯-5-嘧啶甲醛置于selenium(Iv) Oxide,盐酸羟胺,溶剂黄146体系中,用 乙醇,甲苯 作为反应溶剂,化学反应 18.0H,反应生成 4,6-二氯嘧啶-5-甲腈
参考文献:Janus型核苷类似物的合成及其初步生物活性†
标题:Janus型核苷类似物的合成及其初步生物活性†
摘要:新型janus型核苷类似物1A和1B的合成步骤如下:2-氨基-4,6-二羟基嘧啶 和 4,6-二羟基嘧啶.1A的基本部分的一面带有watson-Crick供体-供体-受体(dda)的h键阵列鸟嘌呤 另一张脸带有一个受主-受主-施主(aad)阵列,胞嘧啶,这可能导致其与任一碱基配对 胞嘧啶 或者 鸟嘌呤由于糖基键的旋转.此属性可能使janus型核苷类似物以与以下类似的方式充当抗病毒化合物利巴韦林.既1A和1B是由一个筛选体外hbv Dna复制抑制试验和确实1A显示了巨大的潜力与ic 50 = 10μm和si = 78.9对抗病毒药物的发展.
DOI:10.1039/c0Ob00495B

专利信息

专利号:CN-112851536-A
优先权日:2021-01-04
标题:A kind of method that utilizes pyrimidine condensing agent to click to construct amide bond and its application in synthesis of amide and polypeptide

专利号:CN-112851536-B
优先权日:2021-01-04
标 题:A kind of method that utilizes pyrimidine condensing agent to click to construct amide bond and its application in synthesis of amide and polypeptide

专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

专利号:US-2008108611-A1
优先权日:2006-01-19
标 题 :Substituted thienopyrimidine kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
权利人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
摘要:The present invention is directed to thienopyrimidine compounds of formula (I): n n n n n n n n n n and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

专利号:US-8367825-B2
优先权日:2005-12-21
标 题 :Substituted pyrimidinyl oxime kinase inhibitors
发明人：GUOZHANG XU; LEE LILY; HUGHES TERRY V; WETTER STEVEN K; CONNOLLY PETER J; ABAD MARTA C; EMANUEL STUART L; KAMACHI PRABHA S; MIDDLETON STEVEN A; BATTISTA KATHLEEN A; BIGNAN GILLES C
权利人:JANSSEN PHARMACEUTICA NV; GUOZHANG XU; LEE LILY; HUGHES TERRY V; WETTER STEVEN K; CONNOLLY PETER J; ABAD MARTA C; EMANUEL STUART L; KAMACHI PRABHA S; MIDDLETON STEVEN A; BATTISTA KATHLEEN A; BIGNAN GILLES C
摘要:The present invention is directed to substituted pyrimidine compounds of formula (I): n nand forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

专利号:CN-108178748-B
优先权日:2018-01-19
标 题:Synthesis method of 4, 6-dichloropyrimidine-5-carbonitrile