CAS: 53-96-3; N-(9H-Fluoren-2-yl)Acetamide
该化合物是在有机合成和药用化学领域.AAAF显示出在室温下固体和具有特定熔点等特性,可以表明其纯度和结构完整性.此外,该化合物可能在各个溶剂中表现出某些溶性特征,影响其在实验室环境中的使用.该化合物还因其潜在的生物活动而引起兴趣,其中可能包括抗微生物或抗癌特性,使其成为药理学研究的主体.在处理和储存准则方面,应参考安全数据表,如任何化学物质,以确保适当的安全措施.
- 英文名称N-(9H-Fluoren-2-yl)Acetamide
- 中文名称2-乙酰氨基芴
- IUPAC名称N-(9H-fluoren-2-yl)acetamide
- 其它别名2-Aaf; 2-Acetylaminofluorine; 9M98Qlj2Dl; Unii-9M98Qlj2Dl; N-2-Fluorenylacetamide; 2-Fluorenylacetamide; 2-Acetylaminofluorene [hsdb]; 2-Aminoacetylfluorene; Azetylaminofluoren; 2-Acetoaminofluoren
- CAS编号53-96-3
- MFCD编号:MFCD00001116
- EINECS号:200-188-6
- FDA UNII编号:9M98QLJ2DL
- 分子式:C15H13NO分子量:223.27
- 产品CID: 2490140
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
- 熔点192-196 °C
- 沸点364.56 °C at 760 mmHg
- 闪点277.2±7.8 °C
- 密度1.2±0.1 g/cm3
- pKa:14.89±0.20(预测)
- PSA:29.1
- LogP:3.2162
- 折射率1.674
- 蒸汽压0.0±1.1 mmHg at 25°C
- 溶解性Soluble In Acetone, Acetic Acid, Alcohol (Weast, 1986), Glycols, And Fat Solvents (Windholz Et Al., 1983)
- 敏感性1.吸入或与皮肤接触极毒，可能致癌。大量使用时应穿适当的防护服，戴手套和防护静或面罩，使用时如有事故发生或不适之感，应请医生诊治，使用前应得到专门的指导。
- 外观形态类白色至棕褐色结晶粉末
- 储存条件存储低于 +30°C.
- 产品应用该化合物用于参考材料.
MSDS等安全信息
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
CAS号607-57-8 2-硝基芴 | CAS号108-24-7 乙酸酐 | CAS号10387-40-3 硫代乙酸钾 | CAS号74925-71-6 potassiumN-(9H-... | CAS号121-69-7 N,N-二甲基苯胺 | CAS号153-78-6 2-氨基芴 | CAS号72-89-9 乙酰辅酶A | CAS号1405-86-3 甘草酸 | CAS号64-19-7 冰醋酸 | CAS号7647-01-0 盐酸 | CAS号2915-84-6 2,7-二氨基-9H-芴-9-酮 | CAS号3096-52-4 2-硝基芴酮 | CAS号1214-32-0 7-硝基-9H-芴-2-胺 | CAS号29005-18-3 3-硝基-9H-芴-2-胺 | CAS号153-78-6 2-氨基芴 | CAS号28065-98-7 2-phenyl-9H-fluorene | CAS号6955-65-3 9H-Fluoren-9-on... | CAS号7151-57-7 3-chloro-9H-flu... | CAS号7254-06-0 3-氯-9H-芴-9-酮 | CAS号6633-21-2 N-(3-chloro-9-o...合成工艺路线路线简述
- 合成目标产物 2-Acetamidofluorene 主要起始原料 2-Nitrofluorene And Potassium Thioacetate
- (文献来源)合成步骤主要原料 2-Nitrofluorene 和 Potassium Thioacetate
📜2-硝基芴置于4-二甲氨基吡啶,五甲基二乙烯三胺,水,聚甘氨酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 24.0H,反应生成 N-(2-芴基)乙酰胺
参考文献:在水介质中通过级联电子供体-受体复合物进行光燃料硝基还原
标题:在水介质中通过级联电子供体-受体复合物进行光燃料硝基还原
摘要:Eda 复合物的光化学是从与生物分子的基态缔合开始的,该生物分子能够通过特定的基于自由基的机械途径引导化学合成来进行分子间电子转移.在此,我们利用单一供体和多个受体(arno 2,Arno 和 Arnhoh.甘氨酸加合物)之间的电荷转移相互作用,激活了 Eda 复合物光激发的创新级联模式,用于水介质中的硝基还原.三重态猝灭实验,紫外可见分光光度分析,核磁共振滴定和初步动力学研究验证了该机理的合理性和可行性.随着该级联系统在芳胺化合物和商业药物合成(61 个实例)中的成功应用,这些成就凸显了该方案的吸引力,有用性和有效性.
DOI:10.1039/d4Gc02602K
海关参考信息
- 2902300000-甲苯
2912110000-甲醛
2912120000-乙醛
2924199090-其他无环酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7510852-B2
优先权日:2002-10-18
标题:Biosynthetic genes and host cells for the synthesis of polyketide antibiotics and method of use
发明人：ROYER MONIQUE; GABRIEL DEAN W; FRUTOS ROGER; ROTT PHILIPPE
权利人:CIRAD; UNIV FLORIDA
摘要:Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods for plant protection and creating new antibiotics. The novel Albicidin family of antibiotics is disclosed and their structure deduced.
专利号:WO-2012160337-A1
优先权日:2011-05-26
标题:Sulfated oligosaccharides for use in treatment of neurodegenerative diseases
发明人：CAMPION COLIN; PINI ADRIAN PETER JOHN; GOGOI ROBINDRA NATHAN; GILTHORPE JONATHAN
权利人:KING S COLLEGE LONDON; CARBOHYDRATE SYNTHESIS LTD; CAMPION COLIN; PINI ADRIAN PETER JOHN; GOGOI ROBINDRA NATHAN; GILTHORPE JONATHAN
摘要:Compounds which interact with Hl s TONES Compounds of Formula I : • 4''-Sulfo-Fucose [alpha]1-3 (4'-sulfo)-Fucose [alpha]1-3 (4'-Sulfo-Fu- cose [alpha]1-4-Glucuronic acid [beta]1-0-Methyl or • 4' '-Sulfo-Fucose [alpha]1-3 (4'-sulfo)-Fucose [alpha]1-3 (4'-sulfo)- Fucose [alpha]1-3 (4'-Sulfo-Fucose [alpha]1-4-Glucuronic acid [be ta]1-0-Methyl. wherein X is sulfate (-SO 3 H) or phosphate (-PO 3 H); Su is sulfate and sulfation is most likely at the arrowed positions. The compounds above are useful in the inhibition of histones, in particular histone H1. The compounds can be used in medicine and particularly in the prevention and/or treatment of a wide variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
专利号:US-2006269988-A1
优先权日:2002-10-18
标 题 :Complete biosynthetic gene set for synthesis of polyketide antibiotics, including the albicidin family, resistance genes, and uses thereof
专利号:EP-1572966-B1
优先权日:2002-10-18
标题:Complete biosynthetic gene set for synthesis of polyketide antibiotics, including the albicidin family, resistance genes and uses thereof
专利号:EP-1572966-A2
优先权日:2002-10-18
标题:Complete biosynthetic gene set for synthesis of polyketide antibiotics, including the albicidin family, resistance genes and uses thereof
专利号:JP-H07327699-A
优先权日:1994-06-09
标 题:Simultaneous detection of repair DNA synthesis amount and replication DNA synthesis amount of cells
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Cienfuegos JA, Rotellar F, Valenti V. Hepatocyte transplantation. Rev Esp Enferm Dig. 2019 Nov;111(11):896-897. doi: 10.17235/reed.2019.6270/2019. 36(1):63-74. doi: 10.1093/mutage/gez044.
3: Nafisi S, Bonsaii M, Alexis V, Glick J. Binding of 2-acetylaminofluorene to DNA. DNA Cell Biol. 2011 Nov;30(11):955-62. doi: 10.1089/dna.2011.1229. Epub 2011 Jun 13.
12:24-5. 14(3):361-9. doi: 10.2174/1566524013666131118113017. 27(1):189-199. doi: 10.1007/s00775-021-01920-5. Epub 2021 Nov 29. 20(3):107-17. doi: 10.1002/(sici)1520-6866(2000)20:3<107::aid-tcm2>3.0.co;2-8. 4(1):3-9. doi: 10.1016/j.dnarep.2004.08.009.
合成参考文献
参考文献:10.1021/ja202877q
摘要:Traina CA, Bakus RC, Bazan GC. Design and synthesis of monofunctionalized, water-soluble conjugated polymers for biosensing and imaging applications. J Am Chem Soc. 2011 Aug 17;133(32):12600–7. doi: 10.1021/ja202877q.
参考文献:10.2147/ceg.s17114
摘要:Payne CM, Crowley-Skillicorn C, Bernstein C, Holubec H, Bernstein H. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol. 2011;4():75–119.
参考文献:10.3390/ijerph8062533
摘要:Farombi EO, Owoeye O. Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Int J Environ Res Public Health. 2011 Jun;8(6):2533–55.
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