CAS: 51716-63-3; Cis-Tetrahydropentalene-2,5(1H,3H)-Dione

该化合物是一个双环二氯酮,其内含五环核心,具有定义的立体化学,其硬性,饱和结构和双碳基功能使其成为有机合成的多功能中间体,特别是用于建造复杂的多环框架.Cisif 配置增强了其在立体选择性反应中的效用,从而得以准确控制产品几何学.该化合物在标准条件下具有稳定性,符合一系列变异,包括循环添加和核分裂哲学添加.其平衡的再活动特征允许选择性修改,使之适合在制药,农业化学和材料科学方面的应用.该化合物的精确结构也有助于对反应设计进行机械化研究.

结构式图片

相似化合物

74513-16-9 56180-61-1 77483-80-8

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号58648-36-5 1,3,4,6-Pentale... | CAS号82416-02-2 monosodium mono... | CAS号78698-09-6 Vossen's Red Salt | CAS号78698-10-9 Tetramethyl 3-H... | CAS号768-48-9 4-Acetoxy-2-cyc... | CAS号68703-09-3 1,3,4,6-Pentale... | CAS号556-56-9 烯丙基碘 | CAS号111717-99-8 2,5-dihydroxy-1... | CAS号112163-72-1 1,2,3,3a,4,5,6,... | CAS号139462-73-0 2,5-bis(phenyls... | CAS号89487-16-1 2,5-bis[3-(1-et...

合成工艺路线路线简述

    📜4-Acetoxy-Cyclopentenone 在 盐酸体系中,获得 1,3,3A,4,6,6A-Hexahydropentalene-2,5-Dione
    参考文献:Osterthun,V.; Winterfeldt,E.,Chemische Berichte,1977,Vol. 110,P. 146-153
    标题:Osterthun,V.; Winterfeldt,E.,Chemische Berichte,1977,Vol. 110,P. 146-153

    海关参考信息

    专利信息


    专利号:US-9035058-B2
    优先权日:2011-10-12
    标题:Synthesis of MSE-framework type molecular sieves
    发明人:WESTON SIMON C; STROHMAIER KARL G; VROMAN HILDA B
    权利人:WESTON SIMON C; STROHMAIER KARL G; VROMAN HILDA B; EXXONMOBIL RES & ENG CO
    摘要:A method of synthesizing a crystalline molecular sieve having an MSE framework type comprises crystallizing a reaction mixture comprising a source of water, a source of an oxide of a tetravalent element, Y, selected from at least one of silicon, tin, titanium, vanadium, and germanium, optionally a source of a trivalent element, X, a source of an alkali or alkaline earth metal, M, and a source of organic dications, Q, such as 3-hydroxy-1-(4-(1-methylpiperidin-1-ium-1-yl)butyl)quinuclidin-1-ium, 3-hydroxy-1-(5-(1-methylpiperidin-1-ium-1-yl)pentyl)quinuclidin-1-ium, 1,1′-(butane-1,4-diyl)bis(1-methylpiperidin-1-ium), 1,1′-(pentane-1,5-diyl)bis(1-methylpiperidin-1-ium), 1,1′-(hexane-1,6-diyl)bis(1-methylpiperidin-1-ium), and 1,1′-((3as,6as)-octahydropentalene-2,5-diyl)bis(1-methylpiperidin-1-ium).

    专利号:US-5567830-A
    优先权日:1994-02-14
    标题 :Process for synthesis of acetylenic carbinols
    发明人:UPASANI RAVINDRA B
    权利人:COCENSYS INC
    摘要:A method for the preparation of an acetylenic alcohol by reaction of 1,2-dibromoethylene with an alkyl, aryl an heteroaryl lithium in an inert solvent, followed by reaction with a carbonyl-containing compound to give an acetylenic alcohol is disclosed.

    专利号:US-2012122923-A1
    优先权日:2006-06-13
    标 题:Dual molecules containing a peroxide derivative, their synthesis and therapeutic uses
    发明人:COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN
    权利人:COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN; SANOFI AVENTIS; PALUMED SA; CENTRE NAT RECH SCIENT
    摘要:The invention concerns dual molecules corresponding to formula (I): in which: A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; m and n represent independently of one another 0, 1 or 2; R 5 represents a hydrogen atom, an alkyl, cycloalkyl or C 1-3 -alkylene-cycloakyl group; Z 1 and Z 2 represent an alkyl radical, the group Z 1 +Z 2 +C i +C j representing a mono- or polycyclic structure, with one of the Z 1 or Z 2 being able to represent a single bond; R 1 and R 2 , identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; R x and R y forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly substituted by one or more R 3 groups; as a base or a salt to be added to an acid, as a hydrate or solvate, in racemic form, isomers and their mixtures, in addition to their diasteroisomers and their mixtures. Preparation method and use as medications with antimalarial activity.

    专利号:US-4871869-A
    优先权日:1988-01-06
    标题:Optically active bicyclo[3.3.0]octane and processes for the preparation thereof
    发明人:MORI KENJI; TSUJI MASAHIRO
    权利人:NISSHIN FLOUR MILLING CO
    摘要:New intermediate, an optically active (1R,5S,6S,7R)-6-tert-butyldiphenylsilyloxmethyl-7-hydroxy-bicyclo[3.3.0]octan-3-one (I) having high optical purity which is useful for the synthesis of an optically active carbacyclin and an optically active pentalenolactone E methyl ester. The compound (I) is also an intermediate compound serving for the purpose of improving the optical purity of (1R,5S,6S,7R)-3,3-ethylenedioxy-6-hydroxymethyl-7-(2'-tetrahydropyranyloxy)bicyclo[3.3.0]octane. The compound (I) is prepared by reacting (1R,5S,6S,7R)-3,3-ethylenedioxy-6-hydroxymethyl-7-(2'-tetrahydropyranyloxy)bicyclo[3.3.0]octane with tert-butylchlorodiphenylsilane in the presence of a base and removing the ethylenedioxy and tetrahydropyranyl groups of the resultant compound under an acid condition.

    专利号:US-4885246-A
    优先权日:1985-06-04
    标题 :Optically active carbacyclin intermediates and processes for the preparation thereof
    发明人:MORI KENJI; TSUJI MASAHIRO
    权利人:NISSHIN FLOUR MILLING CO
    摘要:New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic compound, (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl-cis-bicyclo[3.3.0]octan-3-one, by treatment of the racemic compound with a microorganism. The microorganism has an ability of specifically reducing the keto group of the (1R,5S) epimer of the racemic compound.

    专利号:US-7566710-B2
    优先权日:2000-04-06
    标题:Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof
    发明人:MEUNIER BERNARD; ROBERT ANNE; DECHY-CABARET ODILE; BENOIT-VICAL FRANCOISE
    权利人:CT NAT DE LA RACHERCHE SCIENT
    摘要:The invention relates to dual molecules formed from coupling products complying with the formula n n n n n n n n n n n n wherein n A represents a residue of molecule with anti-malarial activity, n Y 1 and Y 2 , represent a linear or branched alkylene chain at C1 to C5, or either Y 1 or Y 2 is absent, n U is an amine, amide, sulphonamide, carboxyl, ether or thioether function, said function linking Y 1 and Y 2 , n Z 1 and Z 2 , represent a linear arylene or alkylene, or either Z 1 or Z 2 is absent, or Z 1 +Z 2 together represent a cyclic or polycyclic structure including the junction carbons Ci and Cj, n R 1 and R 2 , represent a hydrogen atom or a functional group capable of increasing the hydrosolubility of the dual molecule, n R x and R y form a cyclic peroxide with 4 to 8 chain links, Cj being one of the peaks of said cyclic peroxide, or -R x or R y is a cyclic peroxide with 4 to 8 chain links, which may comprise 1 or 2 additional oxygen atoms in the cyclic structure, and one or more substituents R 3 , identical or different, at least one R 3 representing a halogen atom, an —OH group, a —CF 3 group, an aryl, an alkyl or alkoxy at C1 to C5, —NO 2 , the other substituent(s) having one of these correspondences or a hydrogen, and their addition salts with pharmacological acceptable acids.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Baader, W. J.; Bastos, E. L., Science of Synthesis, (2009) 38, 439.
    摘要:Collier, S. J.; Xiang, W., Science of Synthesis, (2010) 41, 659.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知