CAS: 5094-33-7; (2S,3R,4S,5R,6R)-2-(4-Aminophenoxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

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34213-86-0 20818-25-1 35599-02-1

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4-nitrophenyl-β-D-galactopyranoside p-nitrophenyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside 4-nitrophenyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate p-(bromoacetamide)phenyl β-D-galactopyranoside Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4-acetylamino-phenoxy)-tetrahydro-pyran-3-yl ester β-D-galactopyranoside 4-amino-phenol

📜4-硝基苯基-D-吡喃葡糖苷置于乙醇,铂体系中,化学反应生成 对氨基苯基-Beta-D-半乳糖苷
参考文献:Chemo-Immunological Studies On Conjugated Carbohydrate-Proteins
标题:Chemo-Immunological Studies On Conjugated Carbohydrate-Proteins
摘要:已经证明,许多倍的伤寒杆菌反应因子的最小剂量可以被特异性免疫血清中的抗体中和. 给定血清的效力可以方便地通过逐渐增加的反应因子量进行滴定. 如果免疫血清被稀释或者如果反应因子的量对于一定量的血清来说太大,那么只能不规则地获得中和效果. 正常和异种血清(治疗性脑膜炎球菌和红斑狼疮马血清)中不含正常凝集素或具有低滴度(1:16)的正常凝集素对伤寒杆菌的反应因子无法进行中和.使用具有正常伤寒杆菌凝集素的血清(1:64稀释)可以获得可疑的中和效果. 中和抗体的滴度在免疫过程中会增加. 免疫血清对静脉注射伤寒杆菌培养滤液引起的死亡具有明确的保护作用.
DOI:10.1084/jem.50.4.521

专利信息

专利号:US-4959323-A
优先权日:1985-11-04
标 题:Production and use of pre S polypeptides of hepatitis B virus
发明人：ACS GEORGE; CHRISTMAN JUDITH K; PRICE PETER; OFFENSPERGER WOLF; WAHL SILKE
权利人:SINAI SCHOOL MEDICINE
摘要:In accordance with the present invention, recombinant plasmids are described which, when inserted into microbial hosts, direct the synthesis of proteins in which preS polypeptides found on the surface of human hepatitis B virus are fused to the enzyme beta -galactosidase. The recombinant plasmids are produced by inserting DNA sequences encoding the preS polypeptides into the lacZ gene, which codes for E. coli beta -galactosidase, carried by the plasmids. Large amounts of the preS- beta -galactosidase fusion proteins can be isolated from microbial cultures carrying the recombinant plasmids. Antigenic determinants of fusion protein so produced are recognized by antibodies to the preS determinants of native hepatitis B virus. The beta -galactosidase activity of such fusion protein is detected by a suitable chromogenic or fluorogenic substrate. PreS- beta -galactosidase fusion proteins so produced can be used in an enzyme-linked immunosorbent assay (ELISA) to diagnose the presence of hepatitis B virus infection. Additionally, the fusion proteins can be cleaved to release preS polypeptides which can be further purified. PreS polypeptides obtained from these fusion proteins can be used to immunize patients against hepatitis B virus.

专利号:US-11326196-B2
优先权日:2016-01-11
标题 :System and method for synthesis of DNA particles and use thereof
发明人：MAZUTIS LINAS; STONYTE GRETA; KISELIOVAS VAIDOTAS; ZILIONIS RAPOLAS; JANULAITIS ARVYDAS; GALINIS ROBERTAS; STUDER SABINE; HILVERT DONALD
权利人:UNIV VILNIUS; ETH ZUERICH; ETH 7LIRICH
摘要:Disclosed is a system and method for production of DNA particles and use thereof. The DNA particles can be produced by amplification of nucleic acid molecule(s). Alternatively, DNA particles can be prepared by condensing multiple DNA molecules. The DNA condensation into a particle is mainly triggered by pyrophosphate and positively charged cations (e.g. magnesium). DNA particles can be applied for numerous biological applications but not limited to directed evolution, proteomics, drug delivery and imaging. DNA particles can be used to synthesize proteins using in vitro transcription/translation reaction.

专利号:US-5362625-A
优先权日:1991-05-15
标 题:Methods and compositions for enzyme complementation assays using the omega region of β-galactosidase
发明人：KREVOLIN MARK; KATES DAVID
权利人:MICROGENICS CORP
摘要:The use of omega-acceptor and omega-donor polypeptides (comprising about two-thirds and one-third of the beta -galactosidase molecule amino and carboxyl termini, respectively), prepared by recombinant DNA techniques, DNA synthesis, or chemical polypeptide synthesis techniques, which are capable of interacting to form an active enzyme complex having catalytic activity characteristic of beta -galactosidase, is described along with improved methods and novel compositions for enzyme complementation assays for qualitative and quantitative determination of a suspected analyte in a sample.

专利号:US-2019002943-A1
优先权日:2016-01-11
标题:System and method for synthesis of dna particles and use thereof

专利号:US-2012231996-A1
优先权日:2006-05-04
标题:Phalloidin derivatives and methods for their synthesis
发明人：LOKEY R SCOTT; SCHURESKO LAURA A
权利人:LOKEY R SCOTT; SCHURESKO LAURA A
摘要:The invention provides a cyclomonomer having actin-binding activity. The cyclomonomer is of utility for the study of the molecular biology of actin polymerization. The cyclomonomer is also useful for the study of and treatment of the toxic effects of Amanita sp. poisoning.

专利号:US-8273403-B2
优先权日:2002-05-10
标题 :Generation of surface coating diversity
发明人：BARDEN MICHAEL C; KAMBOURIS PETER A
权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.