CAS: 43077-29-8; ((1S,2S,5R)-2-Isopropyl-5-Methylcyclohexyl)Diphenylphosphine

该化合物是一种具有独特立体化学特性的手风琴,具有高度的特性和稳定性,适合复杂的金属离子. 这种离子对于催化和有机金属化学来说是理想的,因为它独特的结构特征,提高了它促进预期反应的能力.

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上下游产品

CAS号16052-42-9 (-)-氯代薄荷脑 | CAS号829-85-6 二苯基膦 | CAS号65567-06-8 锂 二苯基磷化物 | CAS号603-35-0 三苯基膦

合成工艺路线路线简述

    📜苄基二苯膦置于15-冠醚-5,Sodium体系中,用 四氢呋喃 作为反应溶剂,化学反应 17.0H,反应生成 (S)-(+)-2-异丙基-5-甲基二苯磷
    参考文献:通过钠选择性裂解c-P键从arcl制备有机膦的方法
    标题:通过钠选择性裂解c-P键从arcl制备有机膦的方法
    摘要:研究了磷化钠r 2 Pna和其他碱金属磷化物r 2 Pm(m = Li和k)的制备,应用和反应机理.r 2 Pna可以通过sd(精细分散在矿物油中的钠)与次膦酸酯r 2 Por'和氯膦r 2 Pc1的反应准确而选择性地制备.r 2 Pna也可以通过选择性裂解c-p键由三芳基膦和二芳基膦制备.在这些反应中,Na优于li和k.r 2 Pna与多种arcl反应以有效产生r 2Par.arcl优于arbr和ari,因为它们只会降低产品收率.另外,Ph 2 Pna优于ph 2 Pli和ph 2 Pk,因为ph 2 Pli不产生与phcl的偶联产物,而ph 2 Pk仅产生低产率的产物.arcl苯环上的吸电子基团极大地促进了与r 2 Pna的反应,而烷基降低了反应活性.氯乙烯和烷基氯rc1也有效地反应.当t-Bucl没有产生相应的产物,金刚烷基卤化物可以高产率得到相应的膦.通过这种方法,由相应的氯化物制备了多种膦.还可以方便地从ph
    DOI:10.1021/acs.Organomet.0C00295

    海关参考信息

    专利信息


    专利号:US-8629134-B2
    优先权日:2007-02-01
    标题:Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one and zilpaterol
    发明人：ALMENA-PEREA JUAN JOSE; BRINK MONIKA; GEIBETA GERHARD; KADYROV RENAT; MEYER THORSTEN
    权利人:ALMENA-PEREA JUAN JOSE; BRINK MONIKA; GEIBETA GERHARD; KADYROV RENAT; MEYER THORSTEN; INTERVET INT BV
    摘要:This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,1-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterol or a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.

    专利号:WO-2024201469-A1
    优先权日:2023-03-29
    标 题:Process for the preparation of amine intermediates
    发明人：YACOVAN AVIHAI; BAR NAHUM ITSIK; KRAKOVICH VLADA; PARNES REGEV; WANG HONGFA; ZHANG QINGLONG; Zi Weiwei
    权利人:ADAMA AGAN LTD
    摘要:The present disclosure relates a process for the preparation of amines as intermediates for the synthesis of triazines, which are suitable for use as herbicides for controlling weeds.

    专利号:EP-2109614-B1
    优先权日:2007-02-01
    标题:Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk][1]-benzazepin-2 [1h]-one and zilpaterol

    专利号:WO-2008092924-A1
    优先权日:2007-02-01
    标题:Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk] [1] -benzazepin-2 [1h] -one and zilpaterol

    专利号:US-2010173892-A1
    优先权日:2007-02-01
    标题:Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-JK][1]-benzazepin-2[1H]-one and zilpaterol

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    主要参考文献

    参考标题:Csoh-Promoted P-Alkylation: A Convenient And Highly Efficient Synthesis Of Tertiary Phosphines
    作者:Matthew T Honaker,Benjamin J Sandefur,James L Hargett,Alicia L Mcdaniel,Ralph Nicholas Salvatore |发布日期:2003.11
    摘要:And Efficient Method For The Synthesis Of Tertiary Phosphines And Ditertiary Phosphines Has Been Developed. In The Presence Of Cesium Hydroxide, Molecular Sieves And Dmf At Room Temperature, Various Secondary Phosphines And Alkyl Bromides Were Examined, And The Results Have Demonstrated That This Methodology Offers A General Synthetic Procedure To Produce Tertiary Phosphines In Moderate To High Yields

    合成参考文献


    摘要:Gandon, V.; Thorimbert, S.; Malacria, M., Science of Synthesis, (2009) 46, 174.
    摘要:van Leeuwen, P. W. N. M., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 437.
    摘要:Kauffman, M. C.; Walsh, P. J., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 483.
    摘要:Clarke, M. L.; Fuentes, J. A., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 236.
    摘要:Mortreux, A.; Sauthier, M.; Monflier, E.; Tilloy, S., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 181.
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