CAS: 42435-88-1; (S)-Methyl 1-Methyl-5-Oxopyrrolidine-2-Carboxylate

该化合物是一种在有机合成和制药中间体中应用的手性丙烯酮衍生物,其立体特性(2S)使合成不对称,特别是生物活性化合物的制作具有价值;酯和立体功能的存在增强了其反应性,允许有选择性的转化,如核生殖性增加或减少;这种化合物经常用于合成诺罗提物剂和其他...

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108963-96-8 190783-99-4 128811-48-3

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CAS号98-79-3 L-焦谷氨酸 | CAS号74-88-4 碘甲烷 | CAS号4931-66-2 L-焦谷氨酸甲酯 | CAS号89531-41-9 5-(羟甲基)-1-甲基吡咯烷-2-酮

合成工艺路线路线简述

    📜L-焦谷氨酸置于硫酸 Sodium Hydride体系中,用 苯 作为反应溶剂,化学反应 46.0H,反应生成 1-甲基-5-氧代-L-脯氨酸甲酯
    参考文献:Beani; Bianchi; Baraldi,Arzneimittel-Forschung/drug Research,1990,Vol. 40,# 11,P. 1187-1191
    标题:Beani; Bianchi; Baraldi,Arzneimittel-Forschung/drug Research,1990,Vol. 40,# 11,P. 1187-1191

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    专利信息


    专利号:US-9440948-B2
    优先权日:2010-09-03
    标题:Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use
    发明人：KEM WILLIAM READE; SOTI FERENC; ROUCHAUD ANNE; XING HONG; LINDSTROM JON; ANDRUD KRISTIN MARIE
    权利人:KEM WILLIAM READE; SOTI FERENC; ROUCHAUD ANNE; XING HONG; LINDSTROM JON; ANDRUD KRISTIN MARIE; UNIV FLORIDA; UNIV PENNSYLVANIA
    摘要:Embodiments of the present disclosure provide for compounds such as those shown in FIG. 1.1 (compounds A, B, C, and D), 2′substituted nicotine compounds, azetidine compounds, ether linked nicotine compounds (FIG. 1.2 , compounds E, F, G, and H), methods of synthesis of the compounds, methods of treatment of a condition using compounds A, B, C, D, 2′substituted nicotine compounds, azetidine compounds, or ether linked nicotine compounds, methods of selectively stimulating alpha7 nAChR and/or alpha4beta2 receptors, and the like.

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    合成参考文献


    参考文献:10.1021/acs.jmedchem.9b00584
    摘要:Homerin G, Jawhara S, Dezitter X, Baudelet D, Dufrénoy P, Rigo B, Millet R, Furman C, Ragé G, Lipka E, Farce A, Renault N, Sendid B, Charlet R, Leroy J, Phanithavong M, Richeval C, Wiart JF, Allorge D, Adriouch S, Vouret-Craviari V, Ghinet A. Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease. J Med Chem. 2020 Mar 12;63(5):2074–94. doi: 10.1021/acs.jmedchem.9b00584.
    参考文献:10.1007/s11368-023-03626-4
    摘要:Sonsri K, Mitsuboshi M, Watanabe A. Stabilization mechanisms of organic matter in Andosols under long-term fertilization as revealed from structural, molecular, and stable isotopic signatures. J Soils Sediments. 2023 Aug 30;24(1):47–59. doi: 10.1007/s11368-023-03626-4.
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