CAS: 38819-10-2; 9-Beta-Arabinosylguanine

相似化合物

118-00-3 2140-71-8 6979-94-8

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CAS号78842-13-4 2'-氟-2'-脱氧鸟苷 | CAS号32976-84-4 2-amino-9-[3,4-... | CAS号34793-14-1 [3,4-diacetylox...

鸟苷置于吡啶,咪唑,4-二甲氨基吡啶,四丁基氟化铵,Sodium Nitrite体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 46.25H,反应生成 9-β-D-糖呋喃鸟嘌呤
参考文献: Modified Oligonucleotides And Methods Of Use[fr] Oligonucléotides Modifiés Et Méthodes D'Utilisation
标题: Modified Oligonucleotides And Methods Of Use[fr] Oligonucléotides Modifiés Et Méthodes D'Utilisation
摘要:修改的寡核苷酸包括在2'和/或3'位置进行修饰的方法以及制备和使用方法,例如用于对抗hbv的方法.

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-5780617-A
优先权日:1990-05-29
标题 :Synthesis of liponucleotides
发明人：VAN DEN BOSCH HENK; VAN WIJK GYSBERT M T; KUMAR RAJ; HOSTETLER KARL Y
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:WO-9118914-A1
优先权日:1990-05-29
标题:Synthesis of glycerol di- and triphosphate derivatives
发明人：VEN DEN BOSCH HENK; VAN WIJK BERT; KUMAR RAJ; HOSTETLER KARL Y
权利人:VICAL INC
摘要:A process for the preparation of glycerophospholipid derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-2016312261-A1
优先权日:2015-04-24
标 题 :Enzymatic production of cytosinic nucleoside analogues
发明人：PASCUAL GILABERT MARTA; DERONCELÉ THOMAS VICTOR M; MONTILLA ARÉVALO RAFAEL
权利人:PLASMIA BIOTECH S L
摘要:The invention relates to the enzymatic production of cytosinic nucleoside analogues. In particular it relates to a new synthesis process of cytosine nucleoside analogues by using nucleoside phosphorylase enzymes, particularly Pyrimidin Nucleoside Phosphorylases (PyNPs) or mixtures of Purine Nucleoside Phosphorylases (PNPs) and PyNPs.

专利号:US-7074596-B2
优先权日:2002-03-25
标 题 :Synthesis and use of anti-reverse mRNA cap analogues
发明人：DARZYNKIEWICZ EDWARD; RHOADS ROBERT E; STEPINSKI JANUSZ
权利人:UNIV LOUISIANA STATE
摘要:The ability to synthesize capped RNA transcripts in vitro has been of considerable value in a variety of applications. However, one-third to one-half of the caps have, until now, been incorporated in the reverse orientation. Such reverse caps impair the translation of in vitro-synthesized mRNAs. Novel cap analogues, such as P 1 -3′-deoxy-7-methylguanosine-5′P 3 -guanosine-5′triphosphate and P 1 -3′-O,7-dimethylguanosine-5′P 3 -guanosine-5′triphosphate, have been designed that are incapable of being incorporated into RNA in the reverse orientation. Transcripts produced with SP6 polymerase using “anti-reverseâ€? cap analogues were of the predicted length. Analysis of the transcripts indicated that reverse caps were not formed. The in vitro translational efficiency of transcripts with the novel “anti-reverseâ€? cap analogues was significantly higher than that of transcripts formed with conventional caps.