专利号:US-4014895-A 优先权日:1972-06-22 标 题:Method for synthesis of optically active thiolactones 发明人:AOKI YASUHIKO; SUZUKI HIROYUKI; AKIYAMA HISAO; OKANO SHIGERU 权利人:SUMITOMO CHEMICAL CO 摘要:A new method for the production of intermediates in the synthesis of an optically active biotin, which comprises reacting a dicarboxylic acid of the formula: ##SPC1## n Or its reactive derivative with an optically active primary amine, reducing the resulting trione with a metal hydride, hydrolyzing the resultant amide-alcohol and treating the thus produced lactone with a thiolactonating agent to give a thiolactone of the formula: ##SPC2## n , the said trione and amide-alcohol being respectively novel and representable by the formulae: ##SPC3##
专利号:US-9440991-B2 优先权日:2013-12-23 标 题:Synthesis of an antiviral compound 发明人:CAGULADA AMY; CHAN JOHANN; CHAN LINA; COLBY DENISE A; KARKI KAPIL KUMAR; KATO DARRYL; KEATON KATIE ANN; KONDAPALLY SUDHA; LEVINS CHRIS; LITTKE ADAM; MARTINEZ RUBEN; PCION DOMINIKA; REYNOLDS TROY; ROSS BRUCE; SANGI MICHAEL; SCHRIER ADAM J; SENG PAMELA; SIEGEL DUSTIN; SHAPIRO NATHAN; TANG DONALD; TAYLOR JAMES G; TRIPP JONATHAN; WALTMAN ANDREW W; YU LAWRENCE 权利人:GILEAD SCIENCES INC 摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
专利号:US-2023364251-A1 优先权日:2020-08-06 标 题:Methods for the synthesis of protein-drug conjugates 发明人:BORCHARDT ALLEN; HUGHES ROBERT MICHAEL 权利人:CIDARA THERAPEUTICS INC 摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.
专利号:US-2017210756-A1 优先权日:2013-12-23 标题 :Synthesis of an antiviral compound
专利号:EP-3087085-B1 优先权日:2013-12-23 标题 :Synthesis of a macrocyclic hcv ns3 inhibiting tripeptide
专利号:EP-4192512-A1 优先权日:2020-08-06 标题 :Methods for the synthesis of protein-drug conjugates
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合成参考文献
参考文献:10.1134/s1068162025602423 摘要:Hakobyan NZ, Madoyan RA, Sukiasyan AG, Sargsyan HA, Barseghyan JL, Danghyan MY, Panosyan HA, Sargsyan AS, Hambardzumyan AA, Hovhannisyan AA, Harutyunyan AS, Harutyunyan AA. Analogues of the Antibiotic Chloramphenicol. Synthesis, Docking, and Biological Properties of Products of N- and O-Acetylation of (1S,2S)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol (D-(–)threoamine). Russ J Bioorg Chem. 2026 Jan 29;52(1). doi: 10.1134/s1068162025602423.