📜3-氯-N,N-二乙基-2,6-二硝基-4-(三氟甲基)苯胺置于氨体系中,用 1,4-二氧六环 用作溶剂,化学反应 40.0H,反应生成氨氟灵
参考文献:Synthesis And Evaluation Of Oryzalin Analogs Against Toxoplasma Gondii
标题:Synthesis And Evaluation Of Oryzalin Analogs Against Toxoplasma Gondii
摘要:The Synthesis And Evaluation Of 20 Dinitroanilines And Related Compounds Against The Obligate Intracellular Parasite Toxoplasma Gondii Is Reported. Using In Vitro Cultures Of Parasites In Human Fibroblasts,We Determined That Most Of These Compounds Selectively Disrupted Toxoplasma Microtubules,And Several Displayed Sub-Micromolar Potency Against The Parasite. The Most Potent Compound Was N(1),N(1)-Dipropyl-2,6-Dinitro-4-(Trifluoromethyl)-1,3-Benzenediamine (18B),Which Displayed An Ic(50) Value Of 36 Nm Against Intracellular T. Gondii. Based On These Data And Another Recent Report [ma,C.; Tran,J.; Gu,F.; ochoa,R.; Li,C.; Sept,D.; Werbovetz,K.; Morrissette,N. Antimicrob. Agents Chemother. 2010,54,1453],An Antimitotic Structure-Activity Relationship For Dinitroanilines Versus Toxoplasma Is Presented. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2010.07.003