CAS: 2629-72-3; 3-(Pyridin-4-yl)Propan-1-Ol

该化合物是一个有机化合物,其特征是其丙烯环和丙醇侧链,其特征是附于丙烯菊酯的氢氧基(-OH)组,该组有助于其极性及水中的溶解性;环的存在使化合物具有基本特性,使其得以参与各种化学反应,包括核生殖替代以及与金属离子的协调;该化合物经常用于有机合成,并作为生产药品和农用化学品的中间体;其结构特性使其得以参与氢结合,影响其物理特性,如沸点和熔点;此外,4-丙烯丙醇可能展示生物活动,使其对药用化学感兴趣;应参考安全数据,以便处理和储存,如同任何化学物质一样,确保采取适当的预防措施.

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相似化合物

6318-43-0 90610-07-4 5264-15-3

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ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    📜异烟酸甲酯置于5%-Palladium/activated Carbon 甲醇,Sodium Tetrahydroborate,Potassium Tert-Butylate,氢气,甲基磺酰氯,三乙胺体系中,用 乙酸乙酯,甲苯 用作溶剂,化学反应 28.5H,反应生成4-吡啶丙醇
    参考文献: Process For The Preparation Of 3-(4-Pyridinyl)-Propanol And Intermediates Useful In Its Synthesis[fr] Procédé De Préparation De 3-(4-Pyridinyl)-Propanol Et Intermédiaires Utilisés Dans Sa Synthèse
    标题: Process For The Preparation Of 3-(4-Pyridinyl)-Propanol And Intermediates Useful In Its Synthesis[fr] Procédé De Préparation De 3-(4-Pyridinyl)-Propanol Et Intermédiaires Utilisés Dans Sa Synthèse
    摘要:一种制备3-(4-吡啶基)-丙醇或其盐以及在其合成中有用的中间体的方法.

    海关参考信息

    专利信息


    专利号:US-9359327-B2
    优先权日:2008-06-30
    标题:Process for the preparation of substituted pyrimidine derivatives
    发明人:CESCO-CANCIAN SERGIO; CHEN HONGFENG; GRIMM JEFFREY S; MANI NEELAKANDHA S; MAPES CHRISTOPHER M; PALMER DAVID C; PIPPEL DANIEL J; SORGI KIRK L; XIAO TONG
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.

    专利号:WO-2011138250-A1
    优先权日:2010-05-03
    标题 :Process for the preparation of 3-(4-pyridinyl)-propanol and intermediates useful in its synthesis
    发明人:ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO
    权利人:DIPHARMA FRANCIS SRL; ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO
    摘要:A process for the preparation of 3-(4-pyridinyl)-propanol or a salt thereof and intermediates useful in its synthesis.

    专利号:US-6492529-B1
    优先权日:2000-01-18
    标题 :Bis pyrazole-1H-pyrazole intermediates and their synthesis
    发明人:KAPADIA SURESH R; SONG JINHUA J; YEE NATHAN K
    权利人:BOEHRINGER INGELHEIM PHARMA
    摘要:Disclosed are aromatic heterocyclic compounds of the formula (I) wherein Ar 1 , Ar 2 , L, Q and X are described herein, and intermediate compounds useful for making such compounds. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. n Also disclosed are processes of making compounds of the formula (I), their intermediates and processes of making such intermediates, including bis pyrazole-1H-pyrazole intermediates of the formula: n wherein Alk, R x and R z are described herein.

    专利号:US-4470986-A
    优先权日:1982-12-21
    标题 :Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
    发明人:BROWNE LESLIE J
    权利人:CIBA GEIGY CORP
    摘要:Disclosed are e.g. 5-(tetrazolylalkyl, hydroxycarbamoylalkyl)imidazo[1,5-a]-pyridines, and methods of synthesis. Said compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombosis and ischaemic heart disease.

    专利号:US-4444775-A
    优先权日:1981-06-22
    标题:Substituted imidazo[1,5-A]pyridines
    发明人:FORD NEVILLE
    权利人:CIBA GEIGY CORP
    摘要:Disclosed are e.g. novel 5-(carboxyalkyl)imidazo[1,5-a]pyridines, their derivatives and methods of synthesis. Said compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombosis and ischaemic heart disease.

    专利号:RU-2194701-C2
    优先权日:1995-12-18
    标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Eric J Mahan, Et Al. Rotaxanes With Fluorocarbon Blocking Groups. Org Lett. 2006 Oct 26;8(22):5085-8.

    合成参考文献


    摘要:M. Tissier and C. Tissier. Bull. Soc. Chim. France 1967, 3155.
    摘要:Das, A.; Ramkumar, N.; Veliks, J., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
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