📜异烟酸甲酯置于5%-Palladium/activated Carbon 甲醇,Sodium Tetrahydroborate,Potassium Tert-Butylate,氢气,甲基磺酰氯,三乙胺体系中,用 乙酸乙酯,甲苯 用作溶剂,化学反应 28.5H,反应生成4-吡啶丙醇 参考文献: Process For The Preparation Of 3-(4-Pyridinyl)-Propanol And Intermediates Useful In Its Synthesis[fr] Procédé De Préparation De 3-(4-Pyridinyl)-Propanol Et Intermédiaires Utilisés Dans Sa Synthèse 标题: Process For The Preparation Of 3-(4-Pyridinyl)-Propanol And Intermediates Useful In Its Synthesis[fr] Procédé De Préparation De 3-(4-Pyridinyl)-Propanol Et Intermédiaires Utilisés Dans Sa Synthèse 摘要:一种制备3-(4-吡啶基)-丙醇或其盐以及在其合成中有用的中间体的方法.
专利号:US-9359327-B2 优先权日:2008-06-30 标题:Process for the preparation of substituted pyrimidine derivatives 发明人:CESCO-CANCIAN SERGIO; CHEN HONGFENG; GRIMM JEFFREY S; MANI NEELAKANDHA S; MAPES CHRISTOPHER M; PALMER DAVID C; PIPPEL DANIEL J; SORGI KIRK L; XIAO TONG 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.
专利号:WO-2011138250-A1 优先权日:2010-05-03 标题 :Process for the preparation of 3-(4-pyridinyl)-propanol and intermediates useful in its synthesis 发明人:ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO 权利人:DIPHARMA FRANCIS SRL; ATTOLINO EMANUELE; DE MARCO ALESSANDRO; ALLEGRINI PIETRO 摘要:A process for the preparation of 3-(4-pyridinyl)-propanol or a salt thereof and intermediates useful in its synthesis.
专利号:US-6492529-B1 优先权日:2000-01-18 标题 :Bis pyrazole-1H-pyrazole intermediates and their synthesis 发明人:KAPADIA SURESH R; SONG JINHUA J; YEE NATHAN K 权利人:BOEHRINGER INGELHEIM PHARMA 摘要:Disclosed are aromatic heterocyclic compounds of the formula (I) wherein Ar 1 , Ar 2 , L, Q and X are described herein, and intermediate compounds useful for making such compounds. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. n Also disclosed are processes of making compounds of the formula (I), their intermediates and processes of making such intermediates, including bis pyrazole-1H-pyrazole intermediates of the formula: n wherein Alk, R x and R z are described herein.
专利号:US-4470986-A 优先权日:1982-12-21 标题 :Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors 发明人:BROWNE LESLIE J 权利人:CIBA GEIGY CORP 摘要:Disclosed are e.g. 5-(tetrazolylalkyl, hydroxycarbamoylalkyl)imidazo[1,5-a]-pyridines, and methods of synthesis. Said compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombosis and ischaemic heart disease.
专利号:US-4444775-A 优先权日:1981-06-22 标题:Substituted imidazo[1,5-A]pyridines 发明人:FORD NEVILLE 权利人:CIBA GEIGY CORP 摘要:Disclosed are e.g. novel 5-(carboxyalkyl)imidazo[1,5-a]pyridines, their derivatives and methods of synthesis. Said compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombosis and ischaemic heart disease.
专利号:RU-2194701-C2 优先权日:1995-12-18 标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using
[参考文献]: Eric J Mahan, Et Al. Rotaxanes With Fluorocarbon Blocking Groups. Org Lett. 2006 Oct 26;8(22):5085-8.
合成参考文献
摘要:M. Tissier and C. Tissier. Bull. Soc. Chim. France 1967, 3155. 摘要:Das, A.; Ramkumar, N.; Veliks, J., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.