CAS: 24666-56-6; 3-Aminopiperidine-2,6-Dione Hydrochloride

相似化合物

2353-44-8 25181-50-4 1801140-47-5

上下游产品

3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine Cbz-L-Gln N-benzyloxycarbonyl-L-isoglutamine N-(2,6-dioxopiperidin-3-yl)-2-phenylacetamide N-(3,6-Dithia-3,4,5,6-tetrahydrophthalyl)-glutaminsaeureimid 2-(2,6-dioxo-3-piperidinyl)-5-nitro-1H-isoindole-1,3(2H)-dione 4-NT 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Dl-谷氨酸置于ammonium Hydroxide,盐酸体系中,用 水,乙醇 用作溶剂,化学反应 2.5H,以82.6%的收率获得3-氨基-2,6-哌啶二酮盐酸盐
参考文献:一种泊马度胺中间体的合成方法
标题:一种泊马度胺中间体的合成方法
摘要:本发明涉及一种泊马度胺中间体的合成方法,具体为泊马度胺关键中间体3‑氨基哌啶‑2,6‑二酮盐酸盐的合成方法.该方法包括如下步骤:通过原料l‑谷氨酸和氨水反应生成l‑谷氨酸的二铵盐,L‑谷氨酸的二铵盐脱去一分子氨气环合生成3‑氨基哌啶‑2,6‑二酮,溶于乙醇中,并向体系内通入盐酸气体,过滤干燥制得3‑氨基哌啶‑2,6‑二酮盐酸盐.反应中未使用有毒,有害物质且单步反应简单易进行.

专利信息

专利号:US-10392364-B2
优先权日:2014-08-11
标题:Process for synthesis of lenalidomide
发明人：RAO RAMAKRISHNA; NANDIPATI RAMADEVI; GOODA RAVI; SHEWALKAR MUKESH PADMAKAR; BHADKE VENKAT VASANTRAO
权利人:AVRA LABORATORIES PVT LTD
摘要:Disclosed herein is an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof.

专利号:US-8981036-B2
优先权日:2012-08-02
标 题:Synthesis of and curing additives for phthalonitriles
发明人：KELLER TEDDY M; LASKOSKI MATTHEW
权利人:KELLER TEDDY M; LASKOSKI MATTHEW; US NAVY
摘要:A composition having a mixture of the below compounds having a mole ratio of at least 1:20. Ar 1 and Ar 2 are independently selected aromatic groups. A composition comprising phthalonitrile compounds that comprise at least 5 mol % of the first compound below. n nA method of: providing a solution of a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; a dihydroxyaromatic compound or anion thereof; an organic transition metal complex or a transition metal salt; an alkaline hydroxide base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form a dimetallic salt of an aromatic ether oligomer. The molar ratio of the dihydroxyaromatic compound to the dichloroaromatic compound is greater than 2:1. Water formed during the heating is concurrently distilled from the solution.

专利号:US-8735532-B2
优先权日:2012-08-02
标题 :Synthesis of and curing additives for phthalonitriles
发明人：KELLER TEDDY M; LASKOSKI MATTHEW; SAAB ANDREW
权利人:KELLER TEDDY M; LASKOSKI MATTHEW; SAAB ANDREW; US NAVY
摘要:A method of: providing a solution of a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; an excess of a dihydroxyaromatic compound; an organic transition metal complex or a transition metal salt; a base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form an aromatic ether oligomer that is a dihydroxy-terminated compound or a dimetallic salt thereof. Water formed during the heating is concurrently distilled from the solution. A method of curing a phthalonitrile monomer in the presence of an acid and a curing agent to form a phthalonitrile thermoset.

专利号:US-9303014-B2
优先权日:2013-05-01
标题:Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
发明人：RUCHELMAN ALEXANDER L; COHEN BENJAMIN M; CHOUDHURY ANUSUYA; KREILEIN MATTHEW M; LEONG WILLIAM W; MAN HON-WAH
权利人:CELGENE CORP
摘要:Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.

专利号:US-8859712-B2
优先权日:2012-08-02
标 题 :Synthesis of and curing additives for phthalonitriles
发明人：KELLER TEDDY M; LASKOSKI MATTHEW; SAAB ANDREW
权利人:KELLER TEDDY M; LASKOSKI MATTHEW; SAAB ANDREW; US GOVERNMENT
摘要:A method of: providing a solution of a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; a dihydroxyaromatic compound; an organic transition metal complex or a transition metal salt; a base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form a dimetallic salt of an aromatic ether oligomer. The molar ratio of the dihydroxyaromatic compound to the dichloroaromatic compound is greater than 2:1. Water formed during the heating is concurrently distilled from the solution.

专利号:US-2016223559-A1
优先权日:2015-02-02
标题:Tetrazine-containing compounds and synthetic methods thereof
发明人：DEVARAJ NEAL K; WU HAOXING; YANG JUN
权利人:UNIV CALIFORNIA
摘要:Described herein are tetrazine derivatives and efficient synthetic methods of synthesis thereof using elimination-Heck cascade reaction. Provided herein is the synthesis of conjugated tetrazines from the tetrazine derivatives. Also provided herein are methods of use of the conjugated tetrazines as fluorogenic probes for live-cell imaging.