CAS: 23094-69-1; (52R,53S,54R,55S,56S)-14,15,16,24,25,26,53,55-Octahydroxy-3,8-Dioxo-53,54,55,56-Tetrahydro-52H-4,7-Dioxa-5(4,2)-Pyrana-1,2(1,2)-Dibenzenacyclooctaphane-56-Yl 3,4,5-Trihydroxybenzoate

该化合物是一种自然形成的多酚化合物,主要存在于各种植物中,特别是在Phyllanthaceae家族中,它以抗氧化剂,抗炎和抗微生物特性著称,因为它对药理学和营养研究都感兴趣;Corilagin展示了一种复杂的结构,其特点是多种氢氧化物组,有助于其再活性和生物活动;该化合物的潜在治疗效果,包括它在调节代谢途径中的作用及其保护性影响氧化性压力方面.此外,Corilagin在各种体外和活体内研究中显示出其影响细胞信号路径的能力的希望,这可能对治疗癌症和糖尿病等疾病产生影响.它在水和有机溶剂中的溶解性各不相同,这可能会影响其生物利用率和在不同应用中的功效.总的来说,Corilagin代表了自然产品化学和药理学中一个重要的兴趣领域,因为其生物活动多种多样.

结构式图片

上下游产品

CAS号81905-83-1 ac1l4jhe | CAS号141968-71-0 | CAS号2485-62-3 (R)-2-氨基-3-巯基丙酸甲酯 | CAS号60976-49-0 老鹳草素 | CAS号132185-49-0 1-O-galloyl-3,6... | CAS号100227-56-3 1-O-galloyl-2,4... | CAS号1707-75-1 1,1-二苯基-2-苦味酰肼

合成工艺路线路线简述

    专利信息


    专利号:EP-0443532-B1
    优先权日:1990-02-20
    标题:Temporary minimal protection synthesis of LH-RH analogs
    发明人:NESTOR JOHN J JR; MCCLURE NATALIE L
    权利人:SYNTEX INC
    摘要:A solid phase synthesis of LH-RH analogs in which the amino acids serine and histidine, if present, are side chain protected during the synthesis with groups labile to selected alpha -amino or deprotecting agents.

    专利号:WO-2004011474-A1
    优先权日:2002-07-31
    标题:Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-6653468-B1
    优先权日:2002-07-31
    标 题 :Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    权利人:ISIS PHARMACEUTICALS INC
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-8703952-B2
    优先权日:2008-12-12
    标题:Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates
    发明人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID
    权利人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID; WISTA LAB LTD
    摘要:The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.

    专利号:US-8450365-B2
    优先权日:2009-05-12
    标 题 :Efficient synthesis of galanthamine
    发明人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
    权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
    摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

    专利号:EP-1685138-B1
    优先权日:2003-11-17
    标题 :Regiospecific synthesis of nicotine derivatives
    发明人:COMINS DANIEL L; KING LAURA S; DESPAGNET EMILIE
    权利人:UNIV NORTH CAROLINA STATE
    摘要:Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine analogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Gupta A, Singh AK, Kumar R, Ganguly R, Rana HK, Pandey PK, Sethi G, Bishayee A, Pandey AK. Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms. Molecules. 2019 Sep 19;24(18):3399. doi: 10.3390/molecules24183399.
    2: Wu C, Huang H, Choi HY, Ma Y, Zhou T, Peng Y, Pang K, Shu G, Yang X. Anti- esophageal Cancer Effect of Corilagin Extracted from Phmllanthi Fructus via the Mitochondrial and Endoplasmic Reticulum Stress Pathways. J Ethnopharmacol. 2021 Apr 6;269:113700. doi: 10.1016/j.jep.2020.113700. Epub 2020 Dec 17. 43(2):967-979. doi: 10.3892/ijmm.2018.4031. Epub 2018 Dec 18.
    4: Tong Y, Zhang G, Li Y, Xu J, Yuan J, Zhang B, Hu T, Song G. Corilagin inhibits breast cancer growth via reactive oxygen species-dependent apoptosis and autophagy. J Cell Mol Med. 2018 Aug;22(8):3795-3807. doi: 10.1111/jcmm.13647. Epub 2018 Jun 19.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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