CAS: 2241337-84-6; (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2-Amino-6-(Methylamino)-9H-Purin-9-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)Amino)Propanoate Hemisulfate
该化合物是用于抑制病毒性RNA聚合酶的核分子磷酸盐,展示了抗RNA病毒(包括丙型肝炎病毒)的有力抗病毒活动,包括丙型肝炎病毒(HCV),其丙型硫酸盐形式增强了稳定性和生物利用率,确保了连贯一致的药源性能.该化合物展示了病毒性聚合酶的高度选择性,最大限度地减少目标外影响和改善治疗安全性.临床和临床研究表明了有利的代谢特征以及细胞内高效地转换为活性三磷酸盐形式.Bemnifosbuvir hemisulfate正在接受调查,以了解其在综合疗法中的潜力,为处理抗病毒菌株提供了一种很有希望的方法.其合成途径优化了可传播性和纯度,支持了稳健的制药发展.
- 英文名称(2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2-Amino-6-(Methylamino)-9H-Purin-9-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)Amino)Propanoate Hemisulfate
- IUPAC名称isopropyl ((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate hemisulfate
- 其它别名Bemnifosbuvir Hemisulfate; (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2-Amino-6-(Methylamino)-9H-Purin-9-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)Amino)Propanoate Sulfate; (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2-Amino-6-(Methylamino)-9H-Purin-9-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)Amino)Propanoate Hemisulfate
- CAS编号2241337-84-6
- MFCD编号:MFCD33551948
- EINECS号:875-889-9
- FDA UNII编号:DAI4WL7JQ6
- 分子式:C48H68F2N14O18P2S分子量:1261.16
- 产品CID: 1159704
- 同类组份化合物CAS1998705-64-8 (free base)2241337-84-6 (hemisulfate)2241337-80-2 (sulfate)
- 产品分类Inhibitors/Agonists → Anti-infection → HCV | Inhibitors/Agonists → Anti-infection → SARS-CoV
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
📜[(2R,3R,4R,5R)-5-(2-Amino-6-Chloropurin-9-yl)-4-Fluoro-4-Methyl-3-(Phenylcarbamoyloxy)Oxolan-2-Yl]Methyl N-Phenylcarbamate 在 N,N-二异丙基乙胺,N-[(Dimethylamino)-3-Oxo-1H-1,2,3-Triazolo[4,5-B]Pyridin-1-Yl-Methylene]-N-Methylmethanaminium Hexafluorophosphate体系中,用 甲醇,二氯甲烷作为反应溶剂,反应 18.0H,获得 Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2-Amino-6-(Methylamino)-9H-Purin-9-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)-L-Alaninate
参考文献:[En] Stereoselective Manufacture Of Selected Purine Phosphoramidates[Fr] Production Stéréosélective De Phosphoramidates De Purine Sélectionnés
标题:[En] Stereoselective Manufacture Of Selected Purine Phosphoramidates[Fr] Production Stéréosélective De Phosphoramidates De Purine Sélectionnés
摘要:本发明提供了制造磷酰胺酰核苷化合物1或其药学上可接受的盐的立体选择性过程.
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B. A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase. Nat Commun. 2022 Feb 2;13(1):621. doi: 10.1038/s41467-022-28113-1.
2: Good SS, Westover J, Jung KH, Zhou XJ, Moussa A, La Colla P, Collu G, Canard B, Sommadossi JP. AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20. doi: 10.1128/AAC.02479-20.
3: Good SS, Moussa A, Zhou XJ, Pietropaolo K, Sommadossi JP. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan- genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. doi: 10.1371/journal.pone.0227104.
📝 需求与反馈
尽可能描述清楚需求与问题信息
