CAS: 207304-86-7; 1-Benzyl 2-Methyl (2S,4S)-4-Aminopyrrolidine-1,2-Dicarboxylate

英文名称1-Benzyl 2-Methyl (2S,4S)-4-Aminopyrrolidine-1,2-Dicarboxylate
中文名称1-苄基2-甲基(2S,4S)-4-氨基吡咯烷-1,2-二羧酸
IUPAC名称1-benzyl 2-methyl (2S,4S)-4-aminopyrrolidine-1,2-dicarboxylate
其它别名(2S,4S)-1-Cbz-4-Amino Pyrrolidine-2-Carboxylic Acid Methylester-Hcl; Methyl (2S,4S)-1-Cbz-4-Aminopyrrolidine-2-Carboxylate Hydrochloride; 1,2-Pyrrolidinedicarboxylic Acid, 4-Amino-, 2-Methyl 1-(Phenylmethyl) Ester, (2S,4S)-
CAS编号207304-86-7
MFCD编号:MFCD06804628
分子式:C14H18N2O4分子量:278.31
产品CID: 1056436
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DMYAHNRIJNKMAH-RYUDHWBXSA-N
InChI=1S/C14H18N2O4/c1-19-13(17)12-7-11(15)8-16(12)14(18)20-9-10-5-3-2-4-6-10/h2-6,11-12H,7-9,15H2,1H3/t11-,12-/m0/s1
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数3.0

相似化合物

171110-72-8 121148-01-4 334999-32-5

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P312-P330-P362-P403+P233-P501-

上下游产品

-(S)-proline methyl ester4(S)-azido-N-(phenylmethoxy)carbonyl-(S)-proline methyl ester methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate methyl (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylate benzyl chloroformate methyl (2S,4S)-1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopyrrolidine-2-carboxylate tert-butyl ((3S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate benzyl (2S,4S)-4-((tert-butoxycarbonyl)amino)-2-(hydroxymethyl)pyrrolidine-1-carboxylate {1-[2-((2S,4S)-4-tert-Butoxycarbonylamino-2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid benzyl ester

合成工艺路线路线简述

📜L-羟基脯氨酸置于吡啶,氯化亚砜,Sodium Azide,氢气,镍,碳酸氢钠体系中,用 1,4-二氧六环,甲醇,水,N,N-二甲基甲酰胺用作溶剂,化学反应生成(2S,4S)-1-Cbz-4-氨基吡咯烷-2-羧酸甲酯
参考文献:Synthesis And Evaluation Of Prolyl Carbamate Nucleic Acids (Prcna)
标题:Synthesis And Evaluation Of Prolyl Carbamate Nucleic Acids (Prcna)
摘要:Carbamate Linked Prolyl Nucleic Acids Are Obtained In High Yield And Purity Under Mild Conditions In Solution And Solid Phase. P-Nitrophenylchloroformate Is Used As The Activating Reagent For Alcohol. Homooligomers Of Prcna Do Not Bind To Dna. The Introduction Of This Modification In Pna Sequences Destabilizes The Triplxes,Inspite Of Enhancement In The Base Stacking.
Doi:10.1081/ncn-100002517