CAS: 206860-50-6; 3-Bromo-2-Oxopropanoic Acid Hydrate
该化合物是一种有机化合物,其特点是存在一个溴原子,一个碳基组和一个酯功能组,该化合物通常具有三碳基,其三碳基为三碳基,二碳基为溴代基,其二碳基系为基,有助于其反应性和有机合成的潜在应用;溴原子的存在,增强了其电益特性,使它成为各种化学反应,包括核生殖器替代和混合反应的有用中间体;此外,氧基(碳基)可参与进一步的反应,如凝聚或减少.3-Bromo-2-oxopanoate,由于具有多种活性,可被用于合成制药,农业化学品和其他精细化学品.与许多溴化化合物一样,必须谨慎处理,因为与溴化有机化合物相关的潜在毒性和环境关切.
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专利信息
专利号:WO-0127095-A1
优先权日:1999-10-14
标 题:Method for producing 2-(n-boc-aminomethyl)-thiazol-4-carboxylic acid
发明人：BUSCHMANN ERNST; PFEIFFER THOMAS
权利人:BASF AG; BUSCHMANN ERNST; PFEIFFER THOMAS
摘要:The synthesis of dolastatin 3, which inhibits cell growth, requires a 2-aminomethyl-thiazol-4-carboxylic acid that is protected on the amino group as a building block. The invention provides a synthesis for producing this compound with a high degree of purity and a high yield so that it is also feasible on an industrial scale. To this end, a glycine thioamide with a protective group on the amino group is reacted preferably with 3-brom-2-oxo-propionic acid in the presence of at least one tertiary amine.
