CAS: 18645-88-0; 3-Fluorobenzene-1,2-Diamine

上下游产品

2-fluoro-6-nitroaniline 2-Fluoroaniline N-(2-fluorophenyl)acetamide 2,6-difluoro-1-nitrobenzene 8-fluoro-2(1H)-quinoxalinone 5-fluoro-2(1H)-quinoxalinone benzimidazole2,3-dihydro-8-fluorothiazolo3,2abenzimidazole 5-fluoro-2-piperazin-1-yl-quinoxaline

📜2-氟苯胺置于盐酸,Tin(II) Chloride Dihdyrate,硝酸,乙酸酐,溶剂黄146体系中,用 乙醇,水 用作溶剂,化学反应 4.5H,反应生成2,3-二氨基氟苯
参考文献:使用非细胞毒性细胞死亡调节剂克服慢性粒细胞性白血病细胞对伊马替尼的耐药性.
标题:使用非细胞毒性细胞死亡调节剂克服慢性粒细胞性白血病细胞对伊马替尼的耐药性.
摘要:最近的研究检查了通过与过氧化物酶体增殖物激活受体γ(pparγ)配体联合治疗克服慢性粒细胞白血病(cml)患者伊马替尼耐药的可能性.吡格列酮是一种完整的pparγ激动剂,通过逐渐消除残留的cml干细胞池,提高了患者的生存率.为了评估pparγ激动剂的药理学特征对规避耐药性的重要性,部分pparγ激动剂4'-(((2-丙基-1H-苯并[d]咪唑-1-基)甲基]-[1,1]研究了替米沙坦衍生的'-联苯基]-2-羧酸和其他相关衍生物.带有[1,1'-联苯]-2-羧酰胺部分的4-取代的苯并咪唑衍生物使k562耐药细胞对伊马替尼治疗敏感.尤其是衍生物18A-F,在10μm时不会激活pparγ超过40%的细胞,从而恢复了伊马替尼在这些细胞中的细胞毒性.细胞死亡调节特性高于吡格列酮.有趣的是,所有新化合物对非耐药性和耐药性细胞均无细胞毒性.他们仅与伊马替尼联用才发挥抗肿瘤作用.
Doi:10.1016/j.Ejmech.2019.111748

专利信息

专利号:US-9242998-B2
优先权日:2013-02-07
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：HE SHUWEN; DAI XING; PALANI ANANDAN; NARGUND RAVI; LAI ZHONG; ZORN NICOLAS; XIAO DONG; DANG QUN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD
权利人:HE SHUWEN; DAI XING; PALANI ANANDAN; NARGUND RAVI; LAI ZHONG; ZORN NICOLAS; XIAO DONG; DANG QUN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9549917-B2
优先权日:2011-09-08
标 题 :Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:CN-119060091-A
优先权日:2023-05-30
标 题 :Zinc complex containing nitrogen-phosphorus double bond, preparation method and application thereof in catalytic synthesis of polylactide

专利号:RU-2042673-C1
优先权日:1988-12-22
标 题 :4-fluoro-2-{[ (4-methoxy- 2-pyridinyl)methyl]sulfinyl} -1h-benzi- midazole or its physiologically acceptable salts, method of their synthesis, and pharmaceutical composition of 4-fluoro -2-mercapto-1h- benzimidazole and 4-fluoro -2-{[(4- methoxy-2-pyridinyl) methyl]thio}-1h -benzimidazole