CAS: 181705-93-1; 4-Fluorophenylzinc Bromide

该化合物是一种有机辛基化合物,其特点是存在一个与锌原子结合的氟化联苯组,并配有一种溴离子;该化合物一般看起来无色状黄色固体,在有机合成中具有反应性,特别是在诸如铃木-米亚乌拉反应等交叉反应中,众所周知;苯基组中的氟原子可影响化合物的电子特性,增强其在各种化学转化中的回动性和选择性. 4-氟联苯-辛基溴经常被用作形成碳-碳联结的核分子,使其在制药和农用化学品合成中具有价值.重要的是,要谨慎地处理这一化合物,因为有机辛基试剂可能具有交火性,对湿气敏感,需要一种惰性大气来储存和使用.应当遵循适当的安全议定书,以减少处理该化合物的风险.

结构式图片

物理性质

MSDS等安全信息

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上下游产品

CAS号460-00-4 对氟溴苯 | CAS号7646-85-7 氯化锌 | CAS号7440-66-6 锌标准溶液 | CAS号352-13-6 4-氟苯基溴化镁 | CAS号70441-63-3 4-氟-N-异丙基苯胺 | CAS号190595-65-4 依折麦布中间体 | CAS号347-39-7 N,N-diethyl-4-f... | CAS号120346-46-5 4-(4-fluorophen...

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    专利信息


    专利号:US-8835476-B2
    优先权日:2005-03-04
    标 题:Synthesis of novel antimicrobials
    发明人：WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
    权利人:WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
    摘要:The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.

    专利号:US-2010076028-A1
    优先权日:2005-03-04
    标 题 :Design and Synthesis of Novel Antimicrobials

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    合成参考文献


    摘要:Sartori, G.; Maggi, R., Science of Synthesis, (2010) 47, 539.
    摘要:Amatore, M.; Aubert, C.; Malacria, M.; Petit, M., Science of Synthesis Knowledge Updates, (2012) 3, 73.
    摘要:Davies, G. H. M.; Wisniewski, S. R., Science of Synthesis Knowledge Updates, (2021) 2, 125.
    摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2013) 2, 260.
    摘要:Gosmini, C.; Corpet, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 680.
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