CAS: 1621681-63-7; 4-(4-(1-((4-Fluorophenyl)Carbamoyl)Cyclopropane-1-Carboxamido)Phenoxy)-6,7-Dimethoxyquinoline 1-Oxide

英文名称4-(4-(1-((4-Fluorophenyl)Carbamoyl)Cyclopropane-1-Carboxamido)Phenoxy)-6,7-Dimethoxyquinoline 1-Oxide
中文名称卡博替尼杂质DYH
IUPAC名称4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6,7-dimethoxyquinoline 1-oxide
其它别名N-[4-[(6,7-Dimethoxy-1-Oxido-4-Quinolinyl)Oxy]Phenyl]-N'-(4-Fluorophenyl)-1,1-Cyclopropanedicarboxamide; Cabozantinib Impurity 1Dyh; 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-Dimethoxy-1-Oxido-4-Quinolinyl)Oxy]Phenyl]-N'-(4-Fluorophenyl)-; 4-(4-(1-((4-Fluorophenyl)Carbamoyl)Cyclopropane-1-Carboxamido)Phenoxy)-6,7-Dimethoxyquinoline 1-Oxide; N-(4-((6,7-Dimethoxyquinolin-4-yl)Oxy)Phenyl)-6,7-Dimethoxyquinolin-4-Amine; Cabozantinib Impurity 04; 4-(4-(1-((4-Fluorophenyl)Carbamoyl)Cyclopropanecarboxamido)Phenoxy)-6,7-Dimethoxyquinoline 1-Oxide; Vitamin B6 Impurity 62
CAS编号1621681-63-7
MFCD编号:MFCD34596854
FDA UNII编号:LKX6L2LD4X
分子式:C28H24FN3O6分子量:517.51
产品CID: 819854
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: FKJJTKYQXXLFPS-UHFFFAOYSA-N
InChI=1S/C28H24FN3O6/c1-36-24-15-21-22(16-25(24)37-2)32(35)14-11-23(21)38-20-9-7-19(8-10-20)31-27(34)28(12-13-28)26(33)30-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(
计算化学: 氢键受体数7.0氢键供体数2.0可旋转键数8.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501-
安全声明H303+H313+H333

上下游产品

cabozantinib ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid cyclopropane-1,1-dicarboxylic acid 1-(chlor°Carbonyl)cyclopropane-1-carboxylic acid

合成工艺路线路线简述

📜卡博替尼置于sodium Perborate Tetrahydrate,溶剂黄146体系中,用0.95 G的收率获得卡博替尼杂质dyh
参考文献: Dosing Of Cabozantinib Formulations[fr] Dosage De Préparations De Cabozantinib
标题: Dosing Of Cabozantinib Formulations[fr] Dosage De Préparations De Cabozantinib
摘要:该发明涉及对n-(4-{[6,7-双(甲氧基)喹啉-4-基]氧基}苯基)-N'-(4-氟苯基)环丙烷-1,1-二甲酰胺(卡博替尼)及其代谢物的各种药物制剂的管理,以实现理想的药代动力学和药效学效果.