CAS: 145626-87-5; 2,2'-Sulphonyldiethane-1-Thiol

上下游产品

1,2,5-三硫杂环庚烷 5,5-二氧化物 Bis(2-Mercaptoethyl) Sulfone Disulfide 145626-93-3
二(2-乙酰基巯基乙基)砜 Bis(2-Acetylmercaptoethyl) Sulfone 17096-46-7

📜二(2-乙酰基巯基乙基)砜置于盐酸体系中,用 甲醇 用作溶剂,化学反应 48.0H,以90%的收率获得2,2'-磺酰基二乙硫醇
参考文献:Synthesis Of Dithiols As Reducing Agents For Disulfides In Neutral Aqueous Solution And Comparison Of Reduction Potentials
标题:Synthesis Of Dithiols As Reducing Agents For Disulfides In Neutral Aqueous Solution And Comparison Of Reduction Potentials
摘要:Several Dithiols Have Been Prepared That Are Useful For The Reduction Of Disulfides In Aqueous Solution. The Reduction Potential Of These Dithiols Have Been Determined From The Measurement Of The Equilibrium Constant Of Thiol/disulfide Interchange With Oxidized Dithiothreitol Using A H-1 NMR Assay. The Values Of Pk(A) Of Some Of The Dithiols Were Measured To Estimate Their Rate Of Reduction Of Disulfides. Bis(2-Mercaptoethyl) Sulfone (2),N,N'-Dimethyl-N,N'-Bis(Mercaptoacetyl)Hydrazine (5),And Meso-2,5-Dimercapto-N,N,N',N'-Tetramethyladipamide (6) Are Especially Interesting As Alternatives To Dithiothreitol For The Reduction Of Disulfides.
Doi:10.1021/jo00055A015

专利信息

专利号:US-2021206899-A1
优先权日:2020-09-14
标 题 :Synthesis of janus dendrimers
发明人：NAJAFI FAEZEH; Salami-Kalajahi Mehdi; ROGHANI-MAMAQANI HOSSEIN
权利人:NAJAFI FAEZEH; SALAMI KALAJAHI MEHDI; ROGHANI MAMAQANI HOSSEIN; SAHAND UNIV OF TECHNOLOGY
摘要:A method for synthesizing Janus dendrimers, including synthesizing a hydrophobized dendrimer by reacting a dendrimer with a carboxylic acid, forming a first dendron with a thiol group by splitting the hydrophobized dendrimer through breaking a disulfide bond of the core into thiol groups, forming a reactive dendron by reacting the thiol group of the first dendron with methyl acrylate and a radical initiator, synthesizing a primary core by reacting the reactive dendron with ethylenediamine (EDA), and forming a Janus dendrimer by synthesizing a second dendron on the primary core. The hydrophobized dendrimer includes a core containing a disulfide bond.

专利号:WO-2024103123-A1
优先权日:2022-11-17
标题 :The synthesis of omapatrilat
发明人：VITALE ROMINA; MARTIN VINCENT ALEXANDRE; FABER WIJNAND; SOMMER ROMAN
权利人:ENDOTHELIUM SCANNING NANOTECHNOLOGY LTD
摘要:Described herein are improved methods of making Compound 1 (4S,7S,10aS)-4-((S)-2- mercapto-3-phenylpropanamido)-5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, or Omapatrilat, and purified Omapatrilat obtained from the improved methods.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-11548909-B2
优先权日:2015-11-06
标 题 :Methods of using nucleotide analogues
发明人：Marma Mong Sano; OLEJNIK JERZY; KORBOUKH ILIA
权利人:ISOPLEXIS CORP
摘要:The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

专利号:EP-4619408-A1
优先权日:2022-11-17
标题 :The synthesis of omapatrilat

专利号:CN-117083377-A
优先权日:2022-05-03
标题 :A chemical-enzyme coupling method for the synthesis of ergothioneine