CAS: 1452-63-7; Picolinohydrazide

相似化合物

5112-36-7 73771-11-6 1452-63-7

上下游产品

CAS号2524-52-9 2-吡啶甲酸乙酯 | CAS号2459-07-6 2-吡啶甲酸甲酯 | CAS号98-98-6 2-吡啶甲酸 | CAS号108921-63-7 4-吗啉基- 2-吡啶基甲硫醇 | CAS号1121-60-4 吡啶-2-甲醛 | CAS号2726-92-3 Pyridine,2,2'-(... | CAS号83417-23-6 3-(吡啶-2-基)-1H-1... | CAS号1046-56-6 5,6-二苯基-3-(2-吡啶... | CAS号3608-75-1 Hydrazinecarbot... | CAS号1121-60-4 吡啶-2-甲醛 | CAS号13428-22-3 Pyridine, 2- (1... | CAS号14778-29-1 2,3-DICYANO-SUC... | CAS号840-79-9 2-Pyridinecarbo... | CAS号1217806-08-0 3-amino-2-picol...

2-吡啶甲酸置于硫酸体系中,化学反应 6.0H,反应生成2-吡啶甲酰肼
参考文献:新型 1,3,4-恶二唑-2-硫醇衍生物:释放抗炎和抗癌药物的治疗潜力
标题:新型 1,3,4-恶二唑-2-硫醇衍生物:释放抗炎和抗癌药物的治疗潜力
摘要:合成了一系列新型取代的 5-苯基-甲基-2-(1-氨基-2-((1,3,4-恶二唑-2-基)硫基)亚乙基)肼-1-羧酸酯支架来评估其作为抗炎剂和抗癌剂的潜力.通过采用h-NMR,C-NMR和lc-Ms分析确定了合成衍生物的结构.特别是,通过利用角叉菜胶诱导的 Sd 大鼠爪水肿和对 Bt474 雌性乳腺癌细胞系的抗癌活性,评估了 13 种衍生物的抗炎活性.在测试的衍生物中,化合物成为关键先导药物,并显示出对爪水肿体积的显着抑制作用 (81 %),并且与阿霉素 (Ic = 6.795 μm) 相比,化合物表现出令人感兴趣的抑制细胞增殖的能力 (Bt474 的 Ic = 3.78 µm). .根据构效关系,供电子取代基与恶二唑核的存在似乎有利于生物活性.进行对接研究以了解合成化合物的分子相互作用,结果表明这些化合物完美对接到蛋白质的活性位点.
Doi:10.1016/j.Molstruc.2024.138749

专利信息

专利号:US-6734309-B1
优先权日:2002-12-23
标题:Process for the synthesis of isonicotinic acid hydrazide
发明人：RAY SUBHASH CHANDRA; NANDI LAKSHMI NARAYAN; SINGH BALDEV; PRASAD HIRALAL; MAHARAJ SUMANT; SARKAR PRODYOT KUMAR; DUTTA PASHUPATI; ROY SHYAM KISHORE; YADAV SATYA NIKETAN; BANDYOPADHYAY ANUP KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The invention provides a process for the manufacture of isonicotinic acid hydrazide(INH) useful in the treatment of tuberculosis. The invention relates to the single step conversion of isonicotinamide by hydrazine hydrate to isonicotinic acid hydrazide (INH) of yield greater than 95% (w/w) and purity more than 99%.

专利号:US-8895747-B2
优先权日:2009-07-27
标 题 :Method and substances for preparation of N-substituted pyridinium compounds
发明人：HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

专利号:US-6730787-B1
优先权日:1998-12-04
标题 :2,4Dioxo-5-arylidenimino-1,3-pyrimidines
发明人：KRUTIKOV VIKTOR I; ASHKINAZI RIMMA I
权利人:VIROMAX LLC
摘要:The invention relates to medicine, and more specifically to pharmacology, and in particular to synthetic biologically active derivatives of pyrimidine, and it is designated mainly for use as antiviral, immune-stimulating, antichlamydial, antituberculous, psychodepressant, analgesic, and hepatoprotective remedies. Besides that, these compounds may be used for treating malignant neoplasms, and also in veterinary. The objective of the invention is obtaining new chemical substances possessing pronounced biological activity of wide range. The proposed objective is achieved by synthesis of 2,4-dioxo-5-arylidenimino-1,3-pyrimidines of the general formulawhere R is chosen out of group H, OH, alkoxyl, dialkylamino, benzo, dibenzo, or 3,4-dioxolano General method of producing the claimed compounds and example of synthesis, a list of 25 compounds synthesized and tested, results of identification, and data on wide comparative testing their biological properties and toxicity are presented.

专利号:US-2024335420-A1
优先权日:2021-08-02
标题:N-acylhydrazone compounds capable of inhibiting nav 1.7 and/or nav 1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-Acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein substituents R1 to R4 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, useful in the fields of medicinal chemistry, organic synthesis, as well as in the treatment of pain-related disorders.

专利号:US-10738028-B2
优先权日:2016-05-11
标题:Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor
发明人：HU WENHAO; LV FENGPING; TANG YANG; LI ZIYAN; CHEN CHEN; WEI JIANHAI; DONG SUZHEN; QIAN YU
权利人:RUDONG RUIEN PHARMACEUTICAL TECH CO LTD
摘要:Disclosed are the anti-bacterial activity and the anti-tumor activity of a class of new spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, are effective against many antibiotic-resistant Gram-positive strains by inhibiting the activity of the peptide deformylase required in the synthesis of bacterial proteins, and do not affect the synthetic process of the main proteins of the human body, thus selectively killing bacteria. The spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitor of the present invention, as a class of new anti-bacterial agent, can affect the energy balance of the cancer cells through inhibiting the peptide deformylase of the mitochondria in the cells, so that the mitochondrial membrane is depolarized, ATP is exhausted and cell apoptosis is promoted, and has good inhibitory activities on many cancer cell strains such as colorectal cancer, leukemia, lung cancer, gastric cancer, cervical cancer, breast cancer, prostatic cancer, liver cancer and osteosarcoma at relatively lower concentrations. The structure of exemplary invention spiro three-membered ring and spiro five-membered ring peptide deformylase inhibitors are represented by one or more of:

专利号:CN-109293636-B
优先权日:2018-10-22
标 题 :One-pot synthesis of capsule coordination compound containing Schiff base structural unit, preparation method and application