CAS: 124937-53-7; S-(-)-Tolterodine

上下游产品

(R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide (R)-3-[2-(benzyloxy)-5-methylphenyl]-N,N-diisopropyl-3-phenylpropan-1-amine (4R)-6-methyl-4-phenylchroman-2-ol diisopropylamine2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenylacetate hydr°Chloride 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenylbutyrate hydr°Chloride 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenyl 2-methylpropanoate {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol

📜(4S)-6-甲基-4-苯基色满-2-酮置于palladium On Activated Charcoal 氢气,二异丁基氢化铝体系中,用 甲醇,甲苯 用作溶剂,-25.0~48.0 °C,506.66 Kpa 条件下,反应 17.0H,反应生成(S)-托特罗定
参考文献:通过heck反应获得的香豆素衍生物的不对称加氢,对映体选择性合成(S)-和(R)-托特罗定
标题:通过heck反应获得的香豆素衍生物的不对称加氢,对映体选择性合成(S)-和(R)-托特罗定
摘要:(S)-和(R)-托特罗定的有效且短的对映选择性合成是通过香豆素中间体的不对称氢化而进行的,该香豆素中间体容易通过heck反应从廉价且可商购的起始原料中获得.
Doi:10.1021/jo0705667

专利信息

专利号:US-10865163-B2
优先权日:2017-12-20
标题:Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds
发明人：YOUNG MICHAEL C; KAPOOR MOHIT
权利人:UNIV TOLEDO
摘要:Methods of synthesizing compounds using CO 2 as a directing group for C—H functionalization, and compounds made thereby, are described.

专利号:US-2007010691-A1
优先权日:2003-07-02
标 题:Enantioselective synthesis of enantiomerically enriched compounds
发明人：PICCOLO ORESS; ULGHERI FAUSTA; MARCHETTI MAURO
权利人:CONSIGLIO NAZIONALE RICERCHE
摘要:Method of preparing an enantiomerically enriched compound of formula (II) comprising enantioselective hydrogenation of a compound of general formula (I): where W, X and Z have the meanings indicated in the description, to give a compound of general formula (II): where W, Y, T and C* have the meanings indicated in the description, in the presence of a catalyst or its suitable precursor based on Rh, Ru or Ir, having an oxidation state of 0, +1 or +2, and containing at least one enantiomerically enriched chiral ligand.

专利号:US-7119212-B2
优先权日:2004-03-30
标 题 :Process for the preparation of tolterodine and intermediates thereof
发明人：COLOMBO LINO; ROSSI ROBERTO; ALLEGRINI PIETRO; CASTALDI GRAZIANO
权利人:DIPHARMA SPA
摘要:A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.

专利号:US-2019185392-A1
优先权日:2017-12-20
标 题 :Carbon Dioxide as a Directing Group for C-H Functionalization Reactions Involving Lewis Basic Amines, Alcohols, Thiols, and Phosphines for the Synthesis of Compounds

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2005005356-A2
优先权日:2003-07-02
标 题 :Enantioselective synthesis of enantiomerically enriched compounds