CAS: 89031-82-3; Tert-Butyl(3-Chloropropoxy)Dimethylsilane

该化合物是一种有机硅化合物,其特征是含有一种附属于氯丙氧和三丁基化合物的硅烷组,该化合物通常具有与硅相联的特性,例如低挥发性,在水解过程中形成硅氧结壳的能力,它可能是一种无色的淡黄色液体,具有中等密度和粘合性.氯丙氧化合物组的存在表明,它具有潜在的再活动性,特别是在核分裂性替代反应中,而二甲基硅酸混合物则有助于其防水特性.该化合物可用于各种用途,包括作为联结剂,表面改良剂或合成更为复杂的有机素材料.应当参考安全数据,因为氯化成分可能构成健康和环境风险.

结构式图片

相似化合物

78878-05-4 89031-84-5 92511-12-1

物理性质

MSDS等安全信息

上下游产品

tert-butyldimethylsilyl chloride 1-chloro-3-hydroxypropane bis(trichloromethyl) carbonate 3-tert-butyldimethylsilyloxy-1-propanol 1-iodo-3-(tert-butyldimethylsilyloxy)propane 1-chloro-3-hydroxypropane (3-((tert-butyldimetylisilyl)oxy)propyl)triphenylphosphonium iodide tert-butyl-dimethyl-silanyloxy)-1-imidazol-1-yl-butyl]-benzonitrile4-[4-(tert-butyl-dimethyl-silanyloxy)-1-imidazol-1-yl-butyl]-benzonitrile

合成工艺路线路线简述

  • 18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane
    标题:Palladium-Catalyzed Synthesis Of (-)-Cephalotoxin And Its Analogs
    作者:Schirok,Hartmut
    参考文献:1998]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Imidazole Solvents: Dichloromethane; 5 Min,Rt; Rt -> 0 °C1.2 Solvents: Dichloromethane; 15 Min,0 °C; 0 °C -> Rt; 16 H,Rt
    标题:Synthesis Of Chemical Probes To Map Sulfenic Acid Modifications On Proteins
    作者:Poole,Leslie B.; Zeng,Bu-Bing; Knaggs,Sarah A.; Yakubu,Mamudu; King,S. Bruce
    参考文献:Bioconjugate Chemistry 日期:2005 卷标:16(6) 页码:1624-1628]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Imidazole Solvents: Dichloromethane; 16 H,Rt
    标题:Mining The Thiol Proteome For Sulfenic Acid Modifications Reveals New Targets For Oxidation In Cells
    作者:Leonard,Stephen E.; Reddie,Khalilah G.; Carroll,Kate S.
    参考文献:Acs Chemical Biology 日期:2009 卷标:4(9) 页码:783-799]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Imidazole Solvents: Dichloromethane; 10 Min,Rt1.2 Solvents: Dichloromethane; 10 Min,Rt; 12 H,Rt
    标题:L-Histidine-Derived Smart Antifouling Biohybrid With Multistimuli Responsivity
    作者:Mohammad,Sk Arif; Dolui,Subrata; Kumar,Devendra; Mane,Shivshankar R.; Banerjee,Sanjib
    参考文献:Biomacromolecules 日期:2021 卷标:22(9) 页码:3941-3949]

    73842-99-6 = 89031-82-3
    反应条件:1.1 Reagents: Triethylamine,Triphosgene Solvents: Dichloromethane; 3 Min,0 °C; 0 °C -> Rt; 3 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water
    标题:Chlorination Of Aliphatic Primary Alcohols Via Triphosgene-Triethylamine Activation
    作者:Ayala,Caitlan E.; Villalpando,Andres; Nguyen,Alex L.; Mccandless,Gregory T.; Kartika,Rendy
    参考文献:Organic Letters 日期:2012 卷标:14(14) 页码:3676-3679]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 24 H,Rt
    标题:Highly Efficient Antifouling Coating Of Star-Shaped Block Copolymers With Variable Sizes Of Hydrophobic Cores And Charge-Neutral Hydrophilic Arms
    作者:Islam,Muhammad Amirul; Cho,Jae-Young; Azyat,Khalid; Mohammadtabar,Farshad; Gao,Feng; Et Al
    参考文献:Acs Applied Polymer Materials 日期:2021 卷标:3(2) 页码:1116-1134]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Catalysts: Imidazole
    标题:Chlorine Migration In The Mass Spectra Of Tert-Butyldimethylsilyl Derivatives Of Chloro Alcohols
    作者:Hill,Scott T.; Mokotoff,Michael
    参考文献:Journal Of Organic Chemistry 日期:1984 卷标:49(8) 页码:1441-2]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide; 12 H,50 °C
    标题:Influence Of Mono-Lithium Based Initiators With Different Steric Volumes On 1,4 Unit Content Of Hydroxyl Terminated Polybutadiene Using Anionic Polymerization
    作者:Zhu,Xiu-Zhong; Fan,Xiao-Dong; Zhao,Na; Min,Xin; Liu,Jie; Et Al
    参考文献:Rsc Advances 日期:2017 卷标:7(83) 页码:52712-52718]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Imidazole Solvents: Dichloromethane; 5 Min,Rt1.2 5 Min,Rt; 10 H,Rt
    标题:Total Synthesis Of (-)-Goniomitine
    作者:Zhou,Shiqiang; Jia,Yanxing
    参考文献:Organic Letters 日期:2014 卷标:16(12) 页码:3416-3418]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Catalysts: Imidazole Solvents: Dimethylformamide; 30 Min,0 °C; 8 - 10 H,Rt
    标题:Controllable Synthesis And Characterization Of 4Htpi-Si Liquid Rubber With High 1,4-Structure Content Applied To Rocket Solid Propellant Matrix
    作者:Li,Yanhui; Zhang,Caixia; Li,Zhibo; Pan,Guangqin
    参考文献:Journal Of Macromolecular Science 日期:2021 卷标:58(7) 页码:499-507]

    18162-48-6 = 89031-82-3
    反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide; Rt; 16 H,Rt1.2 Reagents: Water
    标题:Synthesis And Unimolecular Esa-Cf Polymer Cyclization Of Zwitterionic Telechelic Precursors
    作者:Konomoto,Tsuneaki; Nakamura,Koji; Yamamoto,Takuya; Tezuka,Yasuyuki
    参考文献:Macromolecules (Washington 日期:2019 卷标:52(23) 页码:9208-9219]

    1000-50-6 = 89031-82-3
    反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide; 50 °C; 5 H,50 °C
    标题:Synthesis Of Hydroxyl-Terminated Polybutadiene Bearing Pendant Carboxyl Groups By Combination Of Anionic Polymerization And Blue Light Photocatalytic Thiol-Ene Reaction And Its Ph-Triggered Self-Assemble Behavior
    作者:Zhang,Wanbin; Zhang,Guanghua; Du,Lun; Zhang,Ce; Li,Lu; Et Al
    参考文献:Reactive & Functional Polymers 日期:2018 卷标:127 页码:161-167
📜叔丁基二甲基氯硅烷,3-氯-1-丙醇置于咪唑体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 18.0H,以95%的收率获得产物1-(叔丁基二甲基硅基)-3-氯丙烷
参考文献:构象受限的法呢基转移酶的5,6,7,8-四氢咪唑并[1,5-A]吡啶抑制剂的合成.
标题:构象受限的法呢基转移酶的5,6,7,8-四氢咪唑并[1,5-A]吡啶抑制剂的合成.
摘要:[反应:见正文]通过胺和亚胺的缩合反应反应生成的亚胺离子的分子内环化反应完成了8-氨基-5,6,7,8-四氢咪唑并[1,5-A]吡啶环系统的合成.取代的γ-(1-咪唑基)丁醛.该反应用于产生构象受限的法尼基转移酶抑制剂类似物,其表现出改善的体内代谢稳定性.
DOI:10.1021/ol0002424

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合成参考文献


摘要:Yi, C. S., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 230.
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