CAS: 656-46-2; 2,2-Difluorobenzo[d][1,3]Dioxole-5-Carboxylic Acid

上下游产品

2,2-二氟苯并[d][1,3]二氧代-5-羧酸甲酯 Methyl 2,2-Difluorobenzo[d][1,3]Dioxole-5-Carboxylate 773873-95-3
2,2-Difluoro-1,3-Benzodioxole-5-Carbonyl Fluoride 656-44-0
5-氰基-2,2-二氟-1,3-苯并二恶茂 5-Cyano-2,2-Difluoro-1,3-Benzodioxole 135132-34-2
2,2-二氟-1,3-苯并二恶茂 2,2-Difluoro-1,3-Benzodioxole 1583-59-1

5-氰基-2,2-二氟-1,3-苯并二恶茂置于水,Sodium Hydroxide体系中,化学反应 5.0H,反应生成 2,2-二氟-1,3-苯并二噁茂-5-羧酸
参考文献:一种2,2-二氟胡椒酸甲酯的制备方法
标题:一种2,2-二氟胡椒酸甲酯的制备方法
摘要:本发明公开了一种2,2‑二氟胡椒酸甲酯的制备方法,所述方法包括如下步骤:将5‑溴‑2,2‑二氟胡椒环和氰化亚铜进行氰化反应,再水解成酸,然后酯化得到2,2‑二氟胡椒酸甲酯.本发明的制备方法,以5‑溴‑2,2‑二氟胡椒环为起始原料,用低毒的氰化亚铜氰化,再水解成酸,甲醇成酯得到产品,方法工艺流程简单,反应过程易控制.工艺的反应过程中,每步生产的中间产物纯化不需要复杂的纯化过程,纯化过程简单,纯化的收率高,致使整个工艺流程简单高效,产品产率高,整个流程成本低,很适合大规模的工业化生产.

专利信息

专利号:US-9782406-B2
优先权日:2011-10-25
标 题 :Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRADUATE SCHOOL; BEIJING RECIPROCAPHARMACEUTICALS CO LTD; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

专利号:US-9150522-B2
优先权日:2011-10-25
标 题:Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRAD SCHO; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

专利号:EP-3835297-B1
优先权日:2010-03-25
标题:Synthesis and intermediates of (r)-1(2,2 -difluorobenzo[d][1,3]dioxol-5yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2yl)-1h-indol-5yl)cyclopropanecarboxamide
发明人：KESHAVARZ-SHOKRI ALI; ZHANG BEILI; ALCACIO TIM EDWARD; LEE ELAINE CHUNGMIN; ZHANG YUEGANG; KRAWIEC MARIUSZ
权利人:VERTEX PHARMA

专利号:EP-3835297-A1
优先权日:2010-03-25
标题 :Synthesis and intermediates of (r)-1(2,2 -difluorobenzo[d][1,3]dioxol-5yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2yl)-1h-indol-5yl)cyclopropanecarboxamide