CAS: 6491-83-4; H-Leu-Leu-Ome.Hcl
- 英文名称H-Leu-Leu-Ome.Hcl
- 中文名称((S)-2-氨基-4-甲基戊酰基)-L-亮氨酸甲酯盐酸盐
- IUPAC名称methyl L-leucyl-L-leucinate hydrochloride
- 其它别名H-Leu-Leu-Ome Hydrochloride; L-Leucyl-L-Leucine Methyl Ester (Hydrochloride); Leucylleucine Methyl Ester Hydrochloride; Leu-Leu-Ome Hydrochloride; Methyl L-Leucyl-L-Leucinate Hydrochloride; Rvxqftnculowrv-Acmtzblwsa-N; 76R0T
- CAS编号6491-83-4
- MFCD编号:MFCD00155477
- FDA UNII编号:76R0TP2LNW
- 分子式:C13H27ClN2O3分子量:294.82
- 产品CID: 1632158
- 产品分类有机原料 → 有机酸及其衍生物 → 羧酸及其衍生物
物理性质
合成工艺路线路线简述
📜Boc-L-亮氨酸置于盐酸,Benzotriazol-1-Yloxyl-Tris-(Pyrrolidino)-Phosphonium Hexafluorophosphate,N,N-二异丙基乙胺体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.0H,反应生成 ((S)-2-氨基-4-甲基戊酰基)-L-亮氨酸甲酯盐酸盐
参考文献:相邻基团对疏水结合热力学的影响:疏水效应增加了复杂的方面
标题:相邻基团对疏水结合热力学的影响:疏水效应增加了复杂的方面
摘要:使用等温滴定量热法(itc)对在浅疏水口袋中结合的配体侧链进行系统修饰的热力学后果进行了评估,无论是否存在相邻的配体羧酸酯基团.数据显示,羧酸盐可能会通过改变未结合状态和结合状态下水合水的h键/组织状态来显着改变这些修饰的相对热力学特征.发现该羧酸酯基团在某些情况下是前焓的,对熵的,而在另一些情况下是反焓的,对熵的.还观测到了显着的焓-熵补偿关系,这反映了疏水作用受相关水环境的热力学状态支配的事实.
DOI:10.1021/jm401609A
海关参考信息
- 2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-8217142-B2
优先权日:1996-07-17
标题 :Liquid phase peptide synthesis of KL-4 pulmonary surfactant
发明人：ABDEL-MAGID AHMED F; EGGMANN URS; MARYANOFF CYNTHIA ANNE; THALER ADRIAN; VILLANI FRANK J
权利人:ABDEL-MAGID AHMED F; EGGMANN URS; MARYANOFF CYNTHIA ANNE; THALER ADRIAN; VILLANI FRANK J; ORTHO PHARMA CORP
摘要:The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu 4 ) 4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon.
专利号:US-6013764-A
优先权日:1996-07-17
标 题:Liquid phase peptide synthesis of KL-4 pulmonary surfactant
专利号:US-2006014929-A9
优先权日:1996-07-17
标 题:Liquid phase peptide synthesis of KL-4 pulmonary surfactant
专利号:US-2009259021-A1
优先权日:1996-07-17
标题 :Liquid Phase Peptide Synthesis of KL-4 Pulmonary Surfactant
专利号:US-2002147302-A1
优先权日:1996-07-17
标题:Liquid phase peptide synthesis of KL-4 pulmonary surfactant
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Barbierato M, Facci L, Argentini C, Marinelli C, Skaper SD, Giusti P. Astrocyte-microglia cooperation in the expression of a pro-inflammatory phenotype. CNS Neurol Disord Drug Targets. 2013 Aug;12(5):608-18. doi: 10.1016/j.imbio.2013.08.011. Epub 2013 Sep 5.
4: Sakauchi H, Furuta T, Kobayashi Y, Iwamura M. Synthesis and cytotoxic studies of 5-O-(beta-glucopyranosyl)-2-nitrobenzyl caged L-leucyl-L-leucine methyl ester with increased solubility in PBS containing 1% DMSO. Biochem Biophys Res Commun. 1997 Apr 7;233(1):211-5.
10: Thiele DL, Calomeni JA, Lipsky PE. Leucyl-leucine methyl ester treatment of donor cells permits establishment of immunocompetent parent----F1 chimeras that are selectively tolerant of host alloantigens. J Immunol. 1987 Oct 1;139(7):2137-42.
合成参考文献
参考文献:10.1186/s12974-025-03574-5
摘要:Calvo Alvarez E, Sfogliarini C, La Rosa F, Saresella M, Dolci M, Vegeto E, Taramelli D, Basilico N, Clerici M. Immune subversion by Leishmania infantum parasites suppresses NLRP3-driven inflammatory responses in amyloid-β-activated microglia. J Neuroinflammation. 2025 Oct 29;22(1):252.
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